| Title : Lobelane analogues as novel ligands for the vesicular monoamine transporter-2 - Zheng_2005_Bioorg.Med.Chem_13_3899 |
| Author(s) : Zheng G , Dwoskin LP , Deaciuc AG , Zhu J , Jones MD , Crooks PA |
| Ref : Bioorganic & Medicinal Chemistry , 13 :3899 , 2005 |
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Abstract :
A series of lobelane analogues has been synthesized and their structure-activity relationships at the vesicular monoamine transporter-2 (VMAT2) have been evaluated. The most potent analogues in this series were the cis-2,6-piperidino analogues, 25b, 27b, 28b, and 30b, with K(i) values ranging from 430 to 580 nM. |
| PubMedSearch : Zheng_2005_Bioorg.Med.Chem_13_3899 |
| PubMedID: 15911306 |
Zheng G, Dwoskin LP, Deaciuc AG, Zhu J, Jones MD, Crooks PA (2005)
Lobelane analogues as novel ligands for the vesicular monoamine transporter-2
Bioorganic & Medicinal Chemistry
13 :3899
Zheng G, Dwoskin LP, Deaciuc AG, Zhu J, Jones MD, Crooks PA (2005)
Bioorganic & Medicinal Chemistry
13 :3899