Title : Combining tacrine with milameline reverses a scopolamine-induced impairment of continuous performance in rhesus monkeys - Callahan_1999_Psychopharmacology.(Berl)_144_234 |
Author(s) : Callahan MJ |
Ref : Psychopharmacology (Berl) , 144 :234 , 1999 |
Abstract :
RATIONALE: Cholinomimetic therapy in Alzheimer's disease (AD) has been hampered by narrow efficacious dose ranges and dose-limiting side effects. These limitations highlight the need for an alternative therapeutic approach for the symptomatic treatment of AD. OBJECTIVES: To determine in rhesus monkeys if combined treatment with the acetylcholinesterase inhibitor tacrine (Cognex) and the muscarinic agonist milameline improve behavioral efficacy in a scopolamine-reversal task without potentiating adverse side effects. |
PubMedSearch : Callahan_1999_Psychopharmacology.(Berl)_144_234 |
PubMedID: 10435389 |
Inhibitor | Tacrine |
Callahan MJ (1999)
Combining tacrine with milameline reverses a scopolamine-induced impairment of continuous performance in rhesus monkeys
Psychopharmacology (Berl)
144 :234
Callahan MJ (1999)
Psychopharmacology (Berl)
144 :234