HS-6
General
Type : Oxime, Bispyridinium
Chemical_Nomenclature : [(E)-[1-[(3-carbamoylpyridin-1-ium-1-yl)methoxymethyl]pyridin-2-ylidene]methyl]-oxoazanium\;dichloride
Canonical SMILES : C1=CC(=C[NH+]=O)N(C=C1)COC[N+]2=CC=CC(=C2)C(=O)N.[Cl-].[Cl-]
InChI : InChI=1S\/C14H14N4O3.2ClH\/c15-14(19)12-4-3-6-17(9-12)10-21-11-18-7-2-1-5-13(18)8-16-20\;\;\/h1-9H,10-11H2,(H-,15,19)\;2*1H\/b13-8+\;\;
InChIKey : ZSQUOZWXBXLUDF-LIYVDSPJSA-N
Other name(s) : 1-[[[3-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium,dichloride || HS 6 || HS 6 (pharmaceutical) || 3'-Carbamoyl-2-formyl-1,1'-(oxydimethylene)dipyridinium dichloride 2-oxime || 1-(((3-(Aminocarbonyl)pyridinio)methoxy)methyl)-2-((hydroxyimino)methyl)pyridinium dichloride
MW : 359.20
Formula : C14H16Cl2N4O3
CAS_number : 22625-23-6
PubChem : 5488846
UniChem : ZSQUOZWXBXLUDF-LIYVDSPJSA-N
Target
Structure : No structure
Families : No family
References (7)
| Title : Potency of five structurally different acetylcholinesterase reactivators to reactivate human brain cholinesterases inhibited by cyclosarin - Kuca_2007_Clin.Toxicol.(Phila)_45_512 |
| Author(s) : Kuca K , Cabal J , Jun D , Hrabinova M |
| Ref : Clinical Toxicology (Phila) , 45 :512 , 2007 |
| Abstract : |
| PubMedSearch : Kuca_2007_Clin.Toxicol.(Phila)_45_512 |
| PubMedID: 17503257 |
| Title : Oxime effects on the rate constants of carbamylation and decarbamylation of acetylcholinesterase for pyridostigmine, physostigmine and insecticidal carbamates - Dawson_1995_Neurochem.Int_26_643 |
| Author(s) : Dawson RM |
| Ref : Neurochem Int , 26 :643 , 1995 |
| Abstract : |
| PubMedSearch : Dawson_1995_Neurochem.Int_26_643 |
| PubMedID: 7670367 |
| Title : Rate constants of carbamylation and decarbamylation of acetylcholinesterase for physostigmine and carbaryl in the presence of an oxime - Dawson_1994_Neurochem.Int_24_173 |
| Author(s) : Dawson RM |
| Ref : Neurochem Int , 24 :173 , 1994 |
| Abstract : |
| PubMedSearch : Dawson_1994_Neurochem.Int_24_173 |
| PubMedID: 8161944 |
| Title : Reactivation of VX-inhibited cholinesterase by 2-PAM and HS-6 in rats - Harris_1983_Drug.Chem.Toxicol_6_235 |
| Author(s) : Harris LW , Stitcher DL |
| Ref : Drug & Chemical Toxicology , 6 :235 , 1983 |
| Abstract : |
| PubMedSearch : Harris_1983_Drug.Chem.Toxicol_6_235 |
| PubMedID: 6628257 |
| Title : Protection and induced reactivation of cholinesterase by HS-6 in rabbits exposed to soman - |
| Author(s) : Harris LW , Stitcher DL , Heyl WC |
| Ref : Life Sciences , 29 :1747 , 1981 |
| PubMedID: 7300570 |
| Title : The ganglionic blocking properties of the cholinesterase reactivator, HS-6 - Lundy_1978_Can.J.Physiol.Pharmacol_56_857 |
| Author(s) : Lundy PM |
| Ref : Canadian Journal of Physiology & Pharmacology , 56 :857 , 1978 |
| Abstract : |
| PubMedSearch : Lundy_1978_Can.J.Physiol.Pharmacol_56_857 |
| PubMedID: 30527 |
| Title : [Effect of some reactivators on cholinesterase activity in the chromodacryorrhea test in rats]. [Bulgarian] - Naneva_1976_Vet.Med.Nauki_13_81 |
| Author(s) : Naneva E |
| Ref : Veterinarno Meditsinski Nauki , 13 :81 , 1976 |
| Abstract : |
| PubMedSearch : Naneva_1976_Vet.Med.Nauki_13_81 |
| PubMedID: 799866 |