Name : X-ray Structure of Novel Biaryl-Based Dipeptidyl peptidase IV inhibitor

Revelation date : 08-Nov-2005

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Qiao, L., Baumann, C.A., Crysler, C.S., Ninan, N.S., Abad, M.C., Spurlino, J.C., Desjarlais, R.L., Kervinen, J., Neeper, M.P., Bayoumy, S.S., Williams, R., Deckman, I.C., Dasgupta, M., Reed, R.L., Huebert, N.D., Tomczuk, B.E., Moriarty, K.J.

Ligand : Inhibitor JNH Ligand in structure: Ligplot

References (1)

Title : Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors - Qiao_2006_Bioorg.Med.Chem.Lett_16_123
Author(s) : Qiao L , Baumann CA , Crysler CS , Ninan NS , Abad MC , Spurlino JC , Desjarlais RL , Kervinen J , Neeper MP , Bayoumy SS , Williams R , Deckman IC , Dasgupta M , Reed RL , Huebert ND , Tomczuk BE , Moriarty KJ
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :123 , 2006
Abstract :
PubMedSearch : Qiao_2006_Bioorg.Med.Chem.Lett_16_123
PubMedID: 16236500
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 2AJL Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 2AJL Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 2AJL Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 2AJL 3D, interactive encyclopedia of proteins - PROTEOPEDIA server