Qiao_2006_Bioorg.Med.Chem.Lett_16_123

Reference

Title : Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors - Qiao_2006_Bioorg.Med.Chem.Lett_16_123
Author(s) : Qiao L , Baumann CA , Crysler CS , Ninan NS , Abad MC , Spurlino JC , Desjarlais RL , Kervinen J , Neeper MP , Bayoumy SS , Williams R , Deckman IC , Dasgupta M , Reed RL , Huebert ND , Tomczuk BE , Moriarty KJ
Ref : Bioorganic & Medicinal Chemistry Lett , 16 :123 , 2006
Abstract :

The discovery, SAR, and X-ray crystal structure of novel biarylaminoacyl-(S)-2-cyano-pyrrolidines and biarylaminoacylthiazolidines as potent inhibitors of dipeptidyl peptidase IV (DPP IV) are reported.

PubMedSearch : Qiao_2006_Bioorg.Med.Chem.Lett_16_123
PubMedID: 16236500
Gene_locus related to this paper: human-DPP4

Related information

Inhibitor JNH    p-Iodo-Phe-Pyr-CN
Gene_locus JNH    p-Iodo-Phe-Pyr-CN    human-DPP4
Structure JNH    p-Iodo-Phe-Pyr-CN    human-DPP4    2AJL

Citations formats

Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ (2006)
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors
Bioorganic & Medicinal Chemistry Lett 16 :123

Qiao L, Baumann CA, Crysler CS, Ninan NS, Abad MC, Spurlino JC, Desjarlais RL, Kervinen J, Neeper MP, Bayoumy SS, Williams R, Deckman IC, Dasgupta M, Reed RL, Huebert ND, Tomczuk BE, Moriarty KJ (2006)
Bioorganic & Medicinal Chemistry Lett 16 :123