3SWW
Name : Crystal structure of human DPP-IV in complex with SA-(+)-3-(aminomethyl)-4-(2,4-dichlorophenyl)-6-(2-methoxyethyl)-2-methyl-5H-pyrrolo[3,4-B]pyridin-7(6H)-one
Revelation date : 26-Oct-2011
Family : DPP4N_Peptidase_S9
Gene_locus : human-DPP4
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Wang, W., Devasthale, P., Wang, A., Harrity, T., Egan, D., Morgan, N., Cap, M., Fura, A., Klei, H.E., Kish, K., Weigelt, C., Sun, L., Levesque, P., Li, Y.X., Zahler, R., Kirby, M.S., Hamann, L.G.
Ligand : Inhibitor CHEMBL1910114 Ligand in structure: Ligplot
References (1)
| Title : 7-Oxopyrrolopyridine-derived DPP4 inhibitors-mitigation of CYP and hERG liabilities via introduction of polar functionalities in the active site - Wang_2011_Bioorg.Med.Chem.Lett_21_6646 |
| Author(s) : Wang W , Devasthale P , Wang A , Harrity T , Egan D , Morgan N , Cap M , Fura A , Klei HE , Kish K , Weigelt C , Sun L , Levesque P , Li YX , Zahler R , Kirby MS , Hamann LG |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :6646 , 2011 |
| Abstract : |
| PubMedSearch : Wang_2011_Bioorg.Med.Chem.Lett_21_6646 |
| PubMedID: 21996520 |
| Gene_locus related to this paper: human-DPP4 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 3SWW Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 3SWW Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 3SWW Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 3SWW 3D, interactive encyclopedia of proteins - PROTEOPEDIA server