4A5S

Name : Crystal Structure of human DDP4 in complex with a novel heterocyclic DPP4 inhibitor

Revelation date : 08-Feb-2012

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Ostermann, N., Kroemer, M., Zink, F., Gerhartz, B., Sutton, J.M., Clark, S.E., Dunsdon, S.J., Fenton, G., Fillmore, A., Harris, N.V., Higgs, C., Hurley, C.A., Krintel, S.L., MacKenzie, R.E., Duttaroy, A., Gangl, E., Maniara, W., Sedrani, R., Namoto, K., Sirockin, F., Trappe, J., Hassiepen, U., Baeschlin, D.K.

Ligand :

References (1)

Title : Novel heterocyclic DPP-4 inhibitors for the treatment of type 2 diabetes. - Sutton_2012_Bioorg.Med.Chem.Lett_22_1464
Author(s) : Sutton JM , Clark DE , Dunsdon SJ , Fenton G , Fillmore A , Harris NV , Higgs C , Hurley CA , Krintel SL , Mackenzie RE , Duttaroy A , Gangl E , Maniara W , Sedrani R , Namoto K , Ostermann N , Gerhartz B , Sirockin F , Trappe J , Hassiepen U , Baeschlin DK
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :1464 , 2012
PubMedID: 22177783
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 4A5S Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 4A5S Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 4A5S Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 4A5S 3D, interactive encyclopedia of proteins - PROTEOPEDIA server