5KBY

Name : Crystal structure of dipeptidyl peptidase IV in complex with SYR-472

Revelation date : 13-Jul-2016

Family : DPP4N_Peptidase_S9

Gene_locus : human-DPP4

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Skene, R.J., Jennings, A.J.

Ligand :

References (1)

Title : Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism - Grimshaw_2016_PLoS.One_11_e0157509
Author(s) : Grimshaw CE , Jennings A , Kamran R , Ueno H , Nishigaki N , Kosaka T , Tani A , Sano H , Kinugawa Y , Koumura E , Shi L , Takeuchi K
Ref : PLoS ONE , 11 :e0157509 , 2016
PubMedID: 27328054
Gene_locus related to this paper: human-DPP4

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 5KBY Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 5KBY Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 5KBY Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 5KBY 3D, interactive encyclopedia of proteins - PROTEOPEDIA server