Name : Crystal structure of human lipoprotein-associated phospholipase A2 in complex with a [1.1.1]bicyclopentane- containing inhibitor at 1.91 A resolution

Revelation date : 01-Feb-2017

Family : PAF-Acetylhydrolase

Gene_locus : human-PLA2G7

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Somers DO

Ligand : Inhibitor 5LP1-71H Ligand in structure: Ligplot

References (1)

Title : Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor - Measom_2017_ACS.Med.Chem.Lett_8_43
Author(s) : Measom ND , Down KD , Hirst DJ , Jamieson C , Manas ES , Patel VK , Somers DO
Ref : ACS Med Chem Lett , 8 :43 , 2017
Abstract :
PubMedSearch : Measom_2017_ACS.Med.Chem.Lett_8_43
PubMedID: 28105273
Gene_locus related to this paper: human-PLA2G7

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 5LP1 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 5LP1 Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 5LP1 Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 5LP1 3D, interactive encyclopedia of proteins - PROTEOPEDIA server