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PAF-Acetylhydrolase

Relationship

Family: PAF-Acetylhydrolase

Block: X

Parent Family: PAF_acetylhydro-like

Comment

Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2 (group-VIIA), responsible for inactivation of platelet-activating factor through cleavage of an acetyl group (PAF: Extracellular signaling lipid; ligand for G protein-coupled platelet activating factor (PAF) receptors). Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, (whose subunits are not alpha/beta hydrolases), the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). Both these last two forms are alpha/beta hydrolases and are included in this family. Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene (human-PLA2G7). This family also contains microbial lipase homologue of PAF-AH_p_II. The first sructure known was Streptomyces exfoliatus lipase

Database

Interpro : IPR005065 PAF_Ac_hydrop_II , IPR016715 Platelet-activating factor acetylhydrolase, eucaryote

PIRSF : No PIRSF

Pdoc : PDOC00110

Pfam : PF03403 PAF-AH_p_II

Prints : PR00821

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
6M08 Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M08-BWO compound 7 human-PLA2G7
6M07 Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M07-BWO compound 8 human-PLA2G7
6M06 Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M06-BWF Compound 5 human-PLA2G7
5LP1 Crystal structure of human lipoprotein-associated phospholipase A2 in complex with a [1.1.1]bicyclopentane- containing inhibitor at 1.91 A resolution human-PLA2G7
5YEA The crystal structure of human Lp-PLA2 in complex with a novel inhibitor human-PLA2G7
5YE9 The crystal structure of human Lp-PLA2 in complex with a novel inhibitor human-PLA2G7
5YE8 The crystal structure of human Lp-PLA2 in complex with a novel inhibitor human-PLA2G7
5YE7 The crystal structure of human Lp-PLA2 in complex with a novel inhibitor human-PLA2G7
5I8P Crystal structure of human LP_PLA2 in complex with novel inhibitor human-PLA2G7
5I9I Crystal structure of human LP_PLA2 in complex with Darapladib human-PLA2G7
5LYY Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 CHEMBL3908555 human-PLA2G7
5LZ2 Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 3-cyano-N-cyclopropylbenzenesulfonamide human-PLA2G7
5LZ4 Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 CHEMBL3975283 human-PLA2G7
5LZ5 Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 CHEMBL3983270 human-PLA2G7
5LZ7 Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 human-PLA2G7
5LZ8 Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 human-PLA2G7
5LZ9 Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 human-PLA2G7
5JAD Compound binding to human Lipoprotein-associated Phospholipase A2 (Lp-PLA2)discovered through fragment screening human-PLA2G7
5JAH Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening human-PLA2G7
5JAL Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening human-PLA2G7
5JAN Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening human-PLA2G7
5JAO Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening human-PLA2G7
5JAP Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening human-PLA2G7
5JAR Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening human-PLA2G7
5JAS Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening human-PLA2G7
5JAT Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening human-PLA2G7
5JAU Exploitation of a novel binding pocket in human Lipoprotein-associated Phospholipase A2 (Lp-PLA2) discovered through X-Ray fragment screening human-PLA2G7
5YAE Ferulic acid esterase from Streptomyces cinnamoneus at 2.4 A resolution (replaces 5EGD 5H26 withdrawn) strcj-estA
5YAL Ferulic acid esterase from Streptomyces cinnamoneus at 1.5 A resolution (replaces 5F4A 5H27 withdrawn) strcj-estA
3F96 Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Sarin human-PLA2G7
3F97 Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Soman human-PLA2G7
3F98 Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Tabun human-PLA2G7
3F9C Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by Diisopropylfluorophosphate human-PLA2G7
3D59 Crystal structure of human plasma platelet activating factor acetylhydrolase human-PLA2G7
3D5E Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by paraoxon human-PLA2G7

Gene_locus Name Species
9bact-Lip114 Uncultured bacterium clone EH40 53D4 pCC1FOS Lip114 uncultured bacterium
strcj-estA Streptomyces cinnamoneus (Streptoverticillium cinnamoneum) estA, R18 Feruoyl esterase strain: NBRC 12852 R18 Streptomyces cinnamoneus
9arch-q5nw20 uncultured archaeon hypothetical protein uncultured archaeon
aspfu-q4wz96 Aspergillus fumigatus Af293 paf acetylhydrolase family protein Aspergillus fumigatus Af293
aspor-q2ud03 Aspergillus oryzae predicted dienelactone hydrolase Aspergillus oryzae
bacam-q70k06 Bacillus amyloliquefaciens hypothetical protein Bacillus amyloliquefaciens
bacan-BA0950 Bacillus anthracis (strain Ames) and Bacillus thuringiensis (subsp. konkukian)hypothetical protein Bacillus anthracis
bacc1-q73cm7 Bacillus cereus (strain ATCC 10987) hypothetical protein Bacillus cereus
bacce-BC0971 Bacillus cereus (strain ATCC 14579 \/ DSM 31) carboxylic ester hydrolase (EC 3.1.1.-) Bacillus cereus
bacce-BC1813 Bacillus cereus (strain ATCC 14579 \/ DSM 31) Bacillus thuringiensis serovar israelensis ATCC 35646 carboxylic ester hydrolase (EC 3.1.1.-) Bacillus cereus
bacha-BH0727 Bacillus halodurans hypothetical protein bh0727 Bacillus halodurans
bacld-q65iy4 Bacillus licheniformis, Bacillus atrophaeus, Geobacillus sp., hypothetical protein (putative choline esterase) Bacillus licheniformis
bacsk-q5wc78 Bacillus clausii (strain KSM-K16) carboxylic ester hydrolase (EC 3.1.1.-) Bacillus clausii
bovin-paf2 Bos taurus (Bovine) (EC 3.1.1.47) (serine dependent phospholipase a2) Bos taurus
bovin-pafa Bovine plasma PAF acetylhydrolase Bos taurus
caebr-a8xjw4 Caenorhabditis briggsae hypothetical protein cbg14389 Caenorhabditis briggsae
caeel-pafa Caenorhabditis elegans platelet-activating factor acetylhydrolase homolog (EC 3.1.1.47) Caenorhabditis elegans
caeel-W03G9.6 Caenorhabditis elegans 1-alkyl-2-acetylglycerophosphocholine esterase (paf-1) Caenorhabditis elegans
canfa-pafa Canis lupus familiaris (Dog) (Canis familiaris), plasma PAF acetylhydrolase Canis lupus familiaris
cavpo-pafa Cavia porcellus (Guinea pig) plasma Paf-acetylhydrolase Cavia porcellus
chagb-q2gr85 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chagb-q2hbc4 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chagb-q2hff2 Chaetomium globosum CBS 148.51 hypothetical protein Chaetomium globosum CBS 148.51
chick-pafa Chick plasma PAF acetylhydrolase Gallus gallus
cryne-q5kec5 Cryptococcus neoformans (Filobasidiella neoformans)(and strain B-3501A) (EC 3.1.1.47) Cryptococcus neoformans
danre-q6nyi7 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:77563 (platelet-activating factor acetylhydrolase, plasma (pla2g7) Danio rerio
dehm1-q3z6z2 Dehalococcoides ethenogenes (strain 195) hypothetical protein Dehalococcoides ethenogenes
emeni-q5b2s1 Aspergillus nidulans FGSC A4 hypothetical protein Aspergillus nidulans FGSC A4
emeni-q5b5m6 Aspergillus nidulans FGSC A4 hypothetical protein Aspergillus nidulans FGSC A4
gibze-q4i8l5 Gibberella zeae (Fusarium graminearum) 1-alkyl-2-acetylglycerophosphocholine esterase Gibberella zeae
gibze-q4ia21 Gibberella zeae (Fusarium graminearum) Putative phospholipase Gibberella zeae
gibze-q4iaf1 Gibberella zeae (Fusarium graminearum) 1-alkyl-2-acetylglycerophosphocholine esterase Gibberella zeae
gibze-q4irg4 Gibberella zeae (Fusarium graminearum) hypothetical protein Gibberella zeae
human-PAFAH2 Homo sapiens (Human) (EC 3.1.1.47) platelet-activating factor acetylhydrolase 2, cytoplasmic (serine dependent phospholipase a2) (hsd-pla2), PAFAH2, PAFA2 PAF-AH Homo sapiens
human-PLA2G7 Homo sapiens (Human) plasma PAF acetylhydrolase Phospholipase A2 groupe 7 PLA2G7 PAFAH PAF-AH Lp-PLA(2) Homo sapiens
kinra-q40vq1 Kineococcus radiotolerans SRS30216 isoform II Kineococcus radiotolerans SRS30216
leiin-a4ibj0 Leishmania infantum 1-alkyl-2-acetylglycerophosphocholine esterase Leishmania infantum
leima-q4fwg8 Leishmania major strain Friedlin phospholipase a2-like protein, putative Leishmania major strain Friedlin
maggr-q2kem4 Magnaporthe grisea 70-15 hypothetical protein Magnaporthe grisea 70-15
mouse-paf2 Mus musculus (Mouse) similar to platelet-activating factor acetylhydrolase 2 (40 kda) Mus musculus
mouse-pafa Mus musculus plasma PAF acetylhydrolase Mus musculus
neucr-q7s2b3 Neurospora crassa Related to platelet-activating factor acetylhydrolase Neurospora crassa
neucr-q7scr4 Neurospora crassa, Neurospora tetrasperma, hypothetical protein Neurospora crassa
nocfa-q5yrp3 Nocardia farcinica putative hydrolase Nocardia farcinica
nocfa-q5yxg3 Nocardia farcinica hypothetical protein Nocardia farcinica
nocfa-q5z1t8 Nocardia farcinica hypothetical protein Nocardia farcinica
pseae-PA1907 Pseudomonas aeruginosa hypothetical protein pa1907 Pseudomonas aeruginosa
ratno-paf2 Rattus norvegicus (Rat) PAFAHII platelet-activating factor acetylhydrolase II Rattus norvegicus
ratno-q5m7t7 Rattus norvegicus (Rat) acetylhydrolase, plasma) (predicted) Rattus norvegicus
rhopa-q6n4k0 Rhodopseudomonas palustris hypothetical protein precursor Rhodopseudomonas palustris
schpo-PLG7 Schizosaccharomyces pombe (strain 972 \/ ATCC 24843) (Fission yeast) SPBC106.11C PLG7 hypothetical protein Schizosaccharomyces pombe
strav-SAV469 Streptomyces avermitilis putative lipase Streptomyces avermitilis
strav-SAV819 Streptomyces avermitilis putative lipase Streptomyces avermitilis
strco-SCD19.23c Streptomyces coelicolor SCD19.23c, possible lipase Streptomyces coelicolor
pig-pafa Sus scrofa (Pig) plasma platelet-activating factor acetylhydrolase Sus scrofa
tetng-q4sgv2 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetts-q22mt6 Tetrahymena thermophila SB210 isoform II family protein Tetrahymena thermophila SB210
tetts-q22nv7 Tetrahymena thermophila SB210 platelet-activating factor acetylhydrolase, plasma\/intracellular isoform II family protein Tetrahymena thermophila SB210
tetts-q230q3 Tetrahymena thermophila SB210 platelet-activating factor acetylhydrolase, plasma\/intracellular isoform II family protein Tetrahymena thermophila SB210
tetts-q240i0 Tetrahymena thermophila SB210 isoform II family protein Tetrahymena thermophila SB210
tryb2-q38de4 Trypanosoma brucei phospholipase a2-like protein, putative Trypanosoma brucei
trycr-q4dvp1 Trypanosoma cruzi phospholipase a2-like protein, putative Trypanosoma cruzi
trycr-q4dvp2 Trypanosoma cruzi phospholipase a2-like protein, putative Trypanosoma cruzi
ustma-q4pd86 Ustilago maydis (strain 521 \/ FGSC 9021) (Corn smut fungus) hypothetical protein Ustilago maydis 521
ustma-q4pid0 Ustilago maydis (strain 521 \/ FGSC 9021) (Corn smut fungus) hypothetical protein Ustilago maydis 521
xenla-q6gpx8 Xenopus laevis (African clawed frog) mgc82533 protein Xenopus laevis
9pezi-a0a010qu33 Colletotrichum fioriniae PJ7. PAF acetylhydrolase Colletotrichum fioriniae PJ7
9euro-a0a017s0c9 Aspergillus ruber CBS 135680. PAF acetylhydrolase family protein Aspergillus ruber CBS 135680
9pezi-a0a074yex2 Aureobasidium subglaciale EXF-2481. Uncharacterized protein Aureobasidium subglaciale EXF-2481
9bacl-a0a089kzd3 Paenibacillus sp. FSL R7-0331. Uncharacterized protein Paenibacillus sp. FSL R7-0331
9pezi-a0a093ydf9 Pseudogymnoascus sp. VKM F-3808. Uncharacterized protein Pseudogymnoascus sp. VKM F-3808
9pezi-a0a093z6d7 Pseudogymnoascus sp. VKM F-3775. Uncharacterized protein Pseudogymnoascus sp. VKM F-3775
9pezi-a0a094e788 Pseudogymnoascus sp. VKM F-103. Uncharacterized protein Pseudogymnoascus sp. VKM F-103
9pezi-a0a094eja3 Pseudogymnoascus sp. VKM F-4513 (FW-928). Uncharacterized protein Pseudogymnoascus sp. VKM F-4513 (FW-928)
9pezi-a0a094g5t2 Pseudogymnoascus sp. VKM F-4517 (FW-2822). Uncharacterized protein Pseudogymnoascus sp. VKM F-4517 (FW-2822)
9noca-a0a0c1czw1 Nocardia vulneris. Uncharacterized protein Nocardia vulneris
9bact-a0a0d2je38 candidate division TM6 bacterium JCVI TM6SC1. Uncharacterized protein candidate division TM6 bacterium JCVI TM6SC1
9bacl-a0a0d3v8d2 Paenibacillus sp. IHBB 10380. Acetylhydrolase Paenibacillus sp. IHBB 10380
9bacl-a0a0d7kf16 Paenibacillus sp. E194. Carboxylic ester hydrolase Paenibacillus sp. E194
asppu-a0a0f0ie42 Aspergillus parasiticus (strain ATCC 56775 \/ NRRL 5862 \/ SRRC 143 \/ SU-1). Platelet-activating factor acetylhydrolase isoform II Aspergillus parasiticus
9bact-a0a0g0gp54 candidate division TM6 bacterium GW2011_GWF2_37_49. Platelet-activating factor acetylhydrolase plasma\/intracellular isoform II candidate division TM6 bacterium GW2011_GWF2_37_49
9bact-a0a0g0gs51 candidate division TM6 bacterium GW2011_GWF2_37_49. Platelet-activating factor acetylhydrolase plasma\/intracellular isoform II candidate division TM6 bacterium GW2011_GWF2_37_49
9bact-a0a0g0xj38 candidate division TM6 bacterium GW2011_GWE2_41_16. Platelet-activating factor acetylhydrolase plasma\/intracellular isoform II candidate division TM6 bacterium GW2011_GWE2_41_16
9bact-a0a0g1hul2 Parcubacteria group bacterium GW2011_GWF2_44_17. Platelet-activating factor acetylhydrolase plasma\/intracellular isoform II Parcubacteria group bacterium GW2011_GWF2_44_17
9bact-a0a0g2zhs2 Kosmotoga pacifica. Uncharacterized protein Kosmotoga pacifica
9cory-a0a0g3h1a5 Corynebacterium mustelae. Alpha\/beta hydrolase family Corynebacterium mustelae
9burk-a0a0k1jv47 Massilia sp. NR 4-1. Uncharacterized protein Massilia sp. NR 4-1
9euro-a0a0m9wbe1 Penicillium nordicum. Uncharacterized protein Penicillium nordicum
9euro-a0a0n0nr39 Phialophora attae. Uncharacterized protein Phialophora attae
9baci-a0a0q3wry6 Bacillus shackletonii. Uncharacterized protein Bacillus shackletonii
9bacl-a0a0q4reh0 Paenibacillus sp. Leaf72. Uncharacterized protein Paenibacillus sp. Leaf72
9gamm-a0a0w0usr3 Legionella gratiana. Alpha\/beta hydrolase family protein Legionella gratiana
9gamm-a0a0w0yih7 Legionella santicrucis. Isoform II Legionella santicrucis
9gamm-a0a0w0yij1 Legionella santicrucis. Isoform II Legionella santicrucis
9gamm-a0a0w0yvk6 Legionella santicrucis. Alpha\/beta hydrolase family protein Legionella santicrucis
9gamm-a0a0w0zhn8 Legionella steelei. Isoform II Legionella steelei
9gamm-a0a0w1abt4 Legionella steigerwaltii. Isoform II Legionella steigerwaltii
penpa-a0a135lje1 Penicillium patulum (Penicillium griseofulvum). Uncharacterized protein Penicillium patulum
9pezi-a0a135swa2 Colletotrichum simmondsii. PAF acetylhydrolase Colletotrichum simmondsii
9pezi-a0a135ufv2 Colletotrichum salicis. PAF acetylhydrolase Colletotrichum salicis
9pezi-a0a135upf4 Colletotrichum salicis. Tat pathway signal sequence Colletotrichum salicis
9euro-a0a146f3d6 Aspergillus luchuensis. PAF acetylhydrolase family protein Aspergillus luchuensis
9pezi-a0a167btm8 Colletotrichum incanum. Paf acetylhydrolase Colletotrichum incanum
9hypo-a0a167x7j9 Aschersonia aleyrodis RCEF 2490. Phospholipase A2 Aschersonia aleyrodis RCEF 2490
9bact-a0a172tzw8 Flavisolibacter sp. LCS9. Uncharacterized protein Flavisolibacter sp. LCS9
9actn-a0a176kvf4 Streptomyces sp. FXJ1.172. Lipase Streptomyces sp. FXJ1.172
9pleo-a0a177c0h8 Paraphaeosphaeria sporulosa. Alpha\/beta-hydrolase Paraphaeosphaeria sporulosa
9euro-a0a177flf3 Fonsecaea monophora. Uncharacterized protein Fonsecaea monophora
9pleo-a0a178b117 Stagonospora sp. SRC1lsM3a. Uncharacterized protein Stagonospora sp. SRC1lsM3a
9bact-a0a182c7f2 Kosmotoga arenicorallina S304. Uncharacterized protein Kosmotoga arenicorallina S304
9bacl-a0a1b2ded2 Paenibacillus sp. BIHB4019. Uncharacterized protein Paenibacillus sp. BIHB4019
9pseu-a0a1b2hwb9 Lentzea guizhouensis. Uncharacterized protein Lentzea guizhouensis
9pezi-a0a1b8cds0 Pseudogymnoascus sp. WSF 3629. Uncharacterized protein Pseudogymnoascus sp. WSF 3629
9pezi-a0a1b8dhv8 Pseudogymnoascus sp. 24MN13. Uncharacterized protein Pseudogymnoascus sp. 24MN13
9pezi-a0a1b8et11 Pseudogymnoascus sp. 05NY08. Uncharacterized protein Pseudogymnoascus sp. 05NY08
9pezi-a0a1b8gb60 Pseudogymnoascus verrucosus. Uncharacterized protein Pseudogymnoascus verrucosus
9pezi-a0a1b8gvu7 Pseudogymnoascus verrucosus. Uncharacterized protein Pseudogymnoascus verrucosus
9bacl-a0a1b8ujf8 Paenibacillus sp. KS1. Carboxylic ester hydrolase Paenibacillus sp. KS1
9bacl-a0a1e1vpc4 Paenibacillus sp. NAIST15-1. Uncharacterized protein Paenibacillus sp. NAIST15-1
9euro-a0a1e3ba25 Aspergillus cristatus. Uncharacterized protein Aspergillus cristatus
9euro-a0a1e3bs39 Aspergillus cristatus. Uncharacterized protein Aspergillus cristatus
9pezi-a0a1g4blr4 Colletotrichum orchidophilum. Tat pathway signal sequence Colletotrichum orchidophilum
9actn-a0a1h1ylk3 Actinoplanes derwentensis. Alpha\/beta hydrolase family protein Actinoplanes derwentensis
9helo-a0a1l7x4l7 Phialocephala subalpina. Uncharacterized protein Phialocephala subalpina
9baci-a0a1l8zgq6 Bacillus obstructivus. Uncharacterized protein Bacillus obstructivus
asptu-a0a1l9nex0 Aspergillus tubingensis CBS 134.48. Uncharacterized protein Aspergillus tubingensis CBS 134.48
9euro-a0a1l9u401 Aspergillus brasiliensis CBS 101740. Uncharacterized protein Aspergillus brasiliensis CBS 101740
aspgl-a0a1l9vqv3 Aspergillus glaucus CBS 516.65. Uncharacterized protein Aspergillus glaucus CBS 516.65
aspgl-a0a1l9vqw5 Aspergillus glaucus CBS 516.65. Uncharacterized protein Aspergillus glaucus CBS 516.65
aspac-a0a1l9whj7 Aspergillus aculeatus ATCC 16872. Uncharacterized protein Aspergillus aculeatus ATCC 16872
parte-a0d7k3 Paramecium tetraurelia. Uncharacterized protein Paramecium tetraurelia
aspnc-a2qt70 Aspergillus niger (strain CBS 513.88 \/ FGSC A1513). Aspergillus niger contig An09c0040, genomic contig Aspergillus niger
colgm-e3qtz0 Colletotrichum graminicola (strain M1.001 \/ M2 \/ FGSC 10212) (Maize anthracnose fungus) (Glomerella graminicola). Tat pathway signal sequence Colletotrichum graminicola
colhi-h1w5n4 Colletotrichum higginsianum (strain IMI 349063) (Crucifer anthracnose fungus). PAF acetylhydrolase Colletotrichum higginsianum
9bact-i2f5c1 Mesotoga prima MesG1.Ag.4.2. Isoform II Mesotoga prima MesG1.Ag.4.2
botpv-r1e9r3 Botryosphaeria parva (strain UCR-NP2) (Grapevine canker fungus) (Neofusicoccum parvum). Putative paf acetylhydrolase family protein Botryosphaeria parva
9firm-r9myz8 Lachnospiraceae bacterium 10-1. Uncharacterized protein Lachnospiraceae bacterium 10-1
9bact-s5ubk7 uncultured bacterium esnapd1.2. Lipase uncultured bacterium esnapd1.2
paeal-s9sn08 Paenibacillus alvei TS-15. Uncharacterized protein Paenibacillus alvei TS-15
9delt-t0rdt7 Bacteriovorax sp. BSW11_IV. Alpha\/beta hydrolase family protein Bacteriovorax sp. BSW11_IV
9psed-u6zwm3 Pseudomonas sp. CMAA1215. Uncharacterized protein Pseudomonas sp. CMAA1215
9caul-v4nlz5 Asticcacaulis sp. AC466. Uncharacterized protein Asticcacaulis sp. AC466
9caul-v4psh7 Asticcacaulis sp. AC460. Uncharacterized protein Asticcacaulis sp. AC460
mizye-a0a210q8u5 Mizuhopecten yessoensis (Japanese scallop) (Patinopecten yessoensis). 1-alkyl-2-acetylglycerophosphocholine esterase Mizuhopecten yessoensis
artbc-a1751 Arthroderma benhamiae (strain ATCC MYA-4681 \/ CBS 112371) (Trichophyton mentagrophytes). Probable 1-alkyl-2-acetylglycerophosphocholine esterase Arthroderma benhamiae

Gene_locus_frgt Name Species
pig-q6ub75 Sus scrofa (Pig) group vii phospholipase a2 (fragment) Sus scrofa
9pezi-a0a093y7w4 Pseudogymnoascus sp. VKM F-3557. Uncharacterized protein Pseudogymnoascus sp. VKM F-3557
9pezi-a0a094fch7 Pseudogymnoascus sp. VKM F-4515 (FW-2607). Uncharacterized protein Pseudogymnoascus sp. VKM F-4515 (FW-2607)

Substrate Chemical Nomenclature Proteins
DNPG 2-[[3-decanoyloxy-2-[5-(4-nitrophenoxy)-5-oxopentanoyl]oxypropoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium human-PLA2G7
Tween-80 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl (E)-octadec-9-enoate crigr-a0a061i7x9    crigr-g3i7x7    human-PLA2G7    ustma-q4pep1    human-LYPLA1
Ethyl-ferulate ethyl (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoate lacjo-q74hk5    biflo-BL0186    asptn-q0ci40    9firm-Est1E    neucr-FAED    lacac-q5fi30    lacga-q040s2    strcj-estA    partm-GthFAE    pyrca-PCEST
4-nitro-3-(octanoyloxy)benzoic-acid 4-nitro-3-octanoyloxybenzoic acid yeren-YPLA    human-PLA2G7
PAF-2-Thio [(2R)-2-acetylsulfanyl-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate human-PLA2G7
PAF [(2R)-2-acetyloxy-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate

Inhibitor Chemical Nomenclature Proteins
DFP Diisopropylphosphorofluoridate arcfu-AF1763    human-DPP4    human-ACHE    human-BCHE    human-PLA2G7    bacce-BC3734    ecoli-IROE    fusso-cutas    human-FAP    human-CTSA    aspni-FAEA
SCHEMBL20516363 [(4R)-2,5-dioxo-4-propan-2-ylimidazolidin-1-yl] 4-[2-chloro-3-(morpholine-4-carbonyl)phenyl]piperazine-1-carboxylate human-ABHD6    human-PLA2G7
7BP-5LZ8 5-[2-[(4S)-4-tert-butyl-2-oxopyrrolidin-1-yl]ethoxy]-2-fluorobenzonitrile human-PLA2G7
CHEMBL3924430 2-fluoro-5-[2-[(4R)-4-methyl-2-oxo-4-phenylpyrrolidin-1-yl]ethoxy]benzonitrile human-PLA2G7
CHEMBL3983270 2-fluoro-5-[2-[(4S)-4-methyl-2-oxo-4-phenylpyrrolidin-1-yl]ethoxy]benzonitrile human-PLA2G7
CHEMBL3975283 5-[2-(4,4-dimethyl-2-oxopyrrolidin-1-yl)ethoxy]-2-fluorobenzonitrile human-PLA2G7
3-cyano-N-cyclopropylbenzenesulfonamide 3-cyano-N-cyclopropylbenzenesulfonamide human-PLA2G7
CHEMBL3908555 3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione human-PLA2G7
AA39-2 [4-(4-phenylphenyl)triazol-1-yl]-pyrrolidin-1-ylmethanone human-PAFAH2
CHEMBL1610004-P9 (4-phenylphenyl) morpholine-4-carboxylate human-PLA2G7
WWL153 (4-nitrophenyl) 4-(2-methylquinolin-4-yl)piperazine-1-carboxylate human-PLA2G7
JMN4 (4-phenylphenyl) 4-(2-methylquinolin-4-yl)piperazine-1-carboxylate human-PLA2G7
CHEMBL3793506 2-[4-chloro-3-(trifluoromethyl)phenoxy]-5-[(1-methyl-6-morpholin-4-yl-2-oxopyrimidin-4-yl)oxymethyl]benzonitrile human-PLA2G7
CHEMBL351434 2-[5-[[1-[2-[dodecyl(methyl)amino]-2-oxoethyl]-2-[(4-fluorophenyl)methylsulfanyl]-4-oxopyrimidin-5-yl]methyl]-2-oxopyrimidin-1-yl]acetic acid human-PLA2G7
SB-222657 2-[(2R)-2-benzylsulfinyl-4-oxoazetidin-1-yl]-N-[6-(4-chlorophenyl)hexyl]acetamide human-PLA2G7
ML225 [4-(4-phenylphenyl)triazol-2-yl]-pyrrolidin-1-ylmethanone human-PAFAH2
6M08-BWL (2S)-2-[(Z)-3-[2-(diethylamino)ethyl-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]amino]-1-hydroxy-3-oxoprop-1-enyl]pyrrolidine-1-carboxylic acid human-PLA2G7
6M07-BWO (2S)-2-[(E)-3-[2-(diethylamino)ethyl-[[4-[2-(2,2,2-trifluoroethoxy)-4-(trifluoromethyl)phenyl]phenyl]methyl]amino]-1-hydroxy-3-oxoprop-1-enyl]pyrrolidine-1-carboxylic acid human-PLA2G7
6M06-BWF (2S)-2-[(Z)-2-carboxy-1-hydroxyethenyl]pyrrolidine-1-carboxylic acid human-PLA2G7
CHEMBL4069230 N-[4-[(4-naphthalen-2-yloxyphenyl)sulfamoyl]phenyl]acetamide human-PLA2G7
CHEMBL4076637 N-(3,4-difluorophenyl)methanesulfonamide human-PLA2G7
CHEMBL4075815 N-[4-[(3-cyano-4-naphthalen-2-yloxyphenyl)sulfamoyl]phenyl]acetamide human-PLA2G7
CHEMBL4076292 4-[[4-[4-chloro-3-(trifluoromethyl)phenoxy]-3-cyanophenyl]sulfamoyl]benzoic acid human-PLA2G7
5LP1-71H N-[2-(diethylamino)ethyl]-2-[2-[(4-fluorophenyl)methylsulfanyl]-4-oxo-7aH-cyclopenta[d]pyrimidin-1-yl]-N-[[3-[4-(trifluoromethyl)phenyl]-1-bicyclo[1.1.1]pentanyl]methyl]acetamide human-PLA2G7
Piperidinyl-1,2,3-triazole-urea-inhibitor-2 4-[4-[2-[(2R)-2-phenylpiperidine-1-carbonyl]triazol-4-yl]phenyl]benzoic acid human-LYPLAL1
HDFP 1-(ethoxy-fluoro-oxidophosphaniumyl)hexadecane human-PREPL
Darapladib N-[2-(diethylamino)ethyl]-2-[2-[(4-fluorophenyl)methylsulfanyl]-4-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-1-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide human-PLA2G7
CHEMBL3792924 4-[[4-[4-chloro-3-(trifluoromethyl)phenoxy]-3,5-difluorophenyl]methoxy]-6-(1,1-dioxo-1,4-thiazinan-4-yl)-1-methylpyrimidin-2-one human-PLA2G7
5LZ9-7BR 2-fluoro-5-[2-[(4S)-4-(4-methyl-1,1-dioxothian-4-yl)-2-oxopyrrolidin-1-yl]ethoxy]benzonitrile human-PLA2G7
GTPL9797 4-amino-N-[4-[4-chloro-3-(trifluoromethyl)phenoxy]-3-cyanophenyl]benzenesulfonamide human-PLA2G7
Rilapladib 2-[2-[(2,3-difluorophenyl)methylsulfanyl]-4-oxoquinolin-1-yl]-N-[1-(2-methoxyethyl)piperidin-4-yl]-N-[[4-[4-(trifluoromethyl)phenyl]phenyl]methyl]acetamide human-PLA2G7
VX-Biotin human-CTSA    human-ACHE    human-BCHE
Paraoxon diethyl (4-nitrophenyl) phosphate human-PLA2G7    human-PNLIPRP2    humin-cut    human-ACHE    promi-c2lfd0    yeast-yjg8    bacpu-AXE    sulto-ST0071    aspor-cutas    pig-1plip    fusso-cutas    lacrh-B2CZF3    thema-TM0033    colgl-cutas    psesp-Q9RBY1    actde-CXE1    myctu-a85c    thema-TM0077    rhimi-lipas    bacpu-w8fke7    9bact-KP212148
Sarin 2-[fluoro(methyl)phosphoryl]oxypropane human-ACHE    human-BCHE    human-CTSA
Soman 3-[fluoro(methyl)phosphoryl]oxy-2,2-dimethylbutane torca-ACHE    human-BCHE    human-PLA2G7    human-CES1    human-CTSA

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Author(s) : Huang F , Wang K , Shen J
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Abstract :
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Gene_locus related to this paper: human-PLA2G7

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Abstract :
PubMedSearch : Woolford_2016_J.Med.Chem_59_5356
PubMedID: 27167608
Gene_locus related to this paper: human-PLA2G7

Title : Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors - Liu_2016_J.Med.Chem_59_5115
Author(s) : Liu Q , Chen X , Chen W , Yuan X , Su H , Shen J , Xu Y
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Abstract :
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Gene_locus related to this paper: human-PLA2G7

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Gene_locus related to this paper: human-PLA2G7

Title : Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution - Wei_1998_Structure_6_511
Author(s) : Wei Y , Swenson L , Castro C , Derewenda U , Minor W , Arai H , Aoki J , Inoue K , Servin-Gonzalez L , Derewenda ZS
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Gene_locus related to this paper: strex-lipas