PAF-Acetylhydrolase

Relationship

Family: PAF-Acetylhydrolase

Block: X

Parent Family: PAF_acetylhydro-like

Comment

Platelet-activating factor acetylhydrolase (PAF-AH) is a subfamily of phospholipases A2 (group-VIIA), responsible for inactivation of platelet-activating factor through cleavage of an acetyl group (PAF: Extracellular signaling lipid; ligand for G protein-coupled platelet activating factor (PAF) receptors). Three known PAF-AHs are the brain heterotrimeric PAF-AH Ib, (whose subunits are not alpha/beta hydrolases), the extracellular, plasma PAF-AH (pPAF-AH), and the intracellular PAF-AH isoform II (PAF-AH II). Both these last two forms are alpha/beta hydrolases and are included in this family. Lipoprotein-associated phospholipase A2 (Lp-PLA2) also known as platelet-activating factor acetylhydrolase (PAF-AH) is a phospholipase A2 enzyme that in humans is encoded by the PLA2G7 gene (human-PLA2G7). This family also contains microbial lipase homologue of PAF-AH_p_II. The first sructure known was Streptomyces exfoliatus lipase

Database

Interpro : IPR005065 PAF_Ac_hydrop_II , IPR016715 Platelet-activating factor acetylhydrolase, eucaryote

PIRSF : No PIRSF

Pdoc : PDOC00110

Pfam : PF03403 PAF-AH_p_II

Prints : PR00821

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (35)

Genes Proteins in PAF-Acetylhydrolase family (145)

Fragments of genes in PAF-Acetylhydrolase family (3)

Structures in PAF-Acetylhydrolase family (35)

Substrates in PAF-Acetylhydrolase family (6)

Inhibitors in PAF-Acetylhydrolase family (35)

References (5)

Title : Lipoprotein-associated phospholipase A2: The story continues - Huang_2020_Med.Res.Rev_40_79
Author(s) : Huang F , Wang K , Shen J
Ref : Med Res Rev , 40 :79 , 2020
PubMedID: 31140638
Gene_locus related to this paper: human-PLA2G7

Title : Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening - Woolford_2016_J.Med.Chem_59_5356
Author(s) : Woolford AJ , Pero JE , Aravapalli S , Berdini V , Coyle JE , Day PJ , Dodson AM , Grondin P , Holding FP , Lee LY , Li P , Manas ES , Marino J, Jr. , Martin AC , McCleland BW , McMenamin RL , Murray CW , Neipp CE , Page LW , Patel VK , Potvain F , Rich S , Rivero RA , Smith K , Somers DO , Trottet L , Velagaleti R , Williams G , Xie R
Ref : Journal of Medicinal Chemistry , 59 :5356 , 2016
PubMedID: 27167608
Gene_locus related to this paper: human-PLA2G7

Title : Structural and Thermodynamic Characterization of Protein-Ligand Interactions Formed between Lipoprotein-Associated Phospholipase A2 and Inhibitors - Liu_2016_J.Med.Chem_59_5115
Author(s) : Liu Q , Chen X , Chen W , Yuan X , Su H , Shen J , Xu Y
Ref : Journal of Medicinal Chemistry , 59 :5115 , 2016
PubMedID: 27078579
Gene_locus related to this paper: human-PLA2G7

Title : Crystal structure of human plasma platelet-activating factor acetylhydrolase: structural implication to lipoprotein binding and catalysis - Samanta_2008_J.Biol.Chem_283_31617
Author(s) : Samanta U , Bahnson BJ
Ref : Journal of Biological Chemistry , 283 :31617 , 2008
PubMedID: 18784071
Gene_locus related to this paper: human-PLA2G7

Title : Structure of a microbial homologue of mammalian platelet-activating factor acetylhydrolases: Streptomyces exfoliatus lipase at 1.9 A resolution - Wei_1998_Structure_6_511
Author(s) : Wei Y , Swenson L , Castro C , Derewenda U , Minor W , Arai H , Aoki J , Inoue K , Servin-Gonzalez L , Derewenda ZS
Ref : Structure , 6 :511 , 1998
PubMedID: 9562561
Gene_locus related to this paper: strex-lipas