5LYY

Name : Fragment-based inhibitors of human Lipoprotein associated Phospholipase A2 CHEMBL3908555

Revelation date : 21-Dec-2016

Family : PAF-Acetylhydrolase

Gene_locus : human-PLA2G7

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Woolford, A.J-A, Day, P.J.

Ligand :

References (1)

Title : Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) - Woolford_2016_J.Med.Chem_59_10738
Author(s) : Woolford AJ , Day PJ , Beneton V , Berdini V , Coyle JE , Dudit Y , Grondin P , Huet P , Lee LY , Manas ES , McMenamin RL , Murray CW , Page LW , Patel VK , Potvain F , Rich SJ , Sang Y , Somers DO , Trottet L , Wan Z , Zhang X
Ref : Journal of Medicinal Chemistry , 59 :10738 , 2016
PubMedID: 27933945
Gene_locus related to this paper: human-PLA2G7

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 5LYY Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 5LYY Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 5LYY Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 5LYY 3D, interactive encyclopedia of proteins - PROTEOPEDIA server