6M06

Name : Crystal structure of Lp-PLA2 in complex with a novel covalent inhibitor 6M06-BWF Compound 5

Revelation date : 30-Dec-2020

Family : PAF-Acetylhydrolase

Gene_locus : human-PLA2G7

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Hu, H.C., Xu, Y.C.

Ligand :

References (1)

Title : Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach - Huang_2020_J.Med.Chem_63_7052
Author(s) : Huang F , Hu H , Wang K , Peng C , Xu W , Zhang Y , Gao J , Liu Y , Zhou H , Huang R , Li M , Shen J , Xu Y
Ref : Journal of Medicinal Chemistry , 63 :7052 , 2020
PubMedID: 32459096
Gene_locus related to this paper: human-PLA2G7

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server

Databases

PDB-Sum : 6M06 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 6M06 Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 6M06 Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 6M06 3D, interactive encyclopedia of proteins - PROTEOPEDIA server