Name : Structure of the human Wnt deacylase Notum in complex with isoquinoline 45 JV8

Revelation date : 08-May-2019

Family : Pectinacetylesterase-Notum

Gene_locus : human-NOTUM

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Atkinson, B.N., Steadman, D., Zhao, Y., Sipthorp, J., Vecchia, L., Ruza, R.R., Jegnathan, F., Lines, G., Frew, S., Monaghan, A., Kjaer, S., Bictash, M., Jones, Y., Fish, P.V.

Ligand :

References (1)

Title : Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen - Atkinson_2019_Medchemcomm_10_1361
Author(s) : Atkinson BN , Steadman D , Zhao YG , Sipthorp J , Vecchia L , Ruza RR , Jeganathan F , Lines G , Frew S , Monaghan A , Kjaer S , Bictash M , Jones Y , Fish PV , Zhao Y , Jones EY
Ref : Medchemcomm , 10 :1361 , 2019
PubMedID: 31534655
Gene_locus related to this paper: human-NOTUM

Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server


PDB-Sum : 6R8R Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server

FSSP : 6R8R Fold classification based on Structure-Structure alignment of Proteins - FSSP server

SCOP : 6R8R Structural Classification Of Protein - SCOP server

PROTEOPEDIA : 6R8R 3D, interactive encyclopedia of proteins - PROTEOPEDIA server