Report for Steadman D

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References (8)

Title : Structural Analysis and Development of Notum Fragment Screening Hits - Zhao_2022_ACS.Chem.Neurosci_13_2060
Author(s) : Zhao Y , Mahy W , Willis NJ , Woodward HL , Steadman D , Bayle ED , Atkinson BN , Sipthorp J , Vecchia L , Ruza RR , Harlos K , Jeganathan F , Constantinou S , Costa A , Kjaer S , Bictash M , Salinas PC , Whiting P , Vincent JP , Fish PV , Jones EY
Ref : ACS Chem Neurosci , 13 :2060 , 2022
Abstract : Zhao_2022_ACS.Chem.Neurosci_13_2060
ESTHER : Zhao_2022_ACS.Chem.Neurosci_13_2060
PubMedSearch : Zhao_2022_ACS.Chem.Neurosci_13_2060
PubMedID: 35731924
Gene_locus related to this paper: human-NOTUM

Title : Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity - Steadman_2022_J.Med.Chem_65_562
Author(s) : Steadman D , Atkinson BN , Zhao Y , Willis NJ , Frew S , Monaghan A , Patel C , Armstrong E , Costelloe K , Magno L , Bictash M , Jones EY , Fish PV , Svensson F
Ref : Journal of Medicinal Chemistry , 65 :562 , 2022
Abstract : Steadman_2022_J.Med.Chem_65_562
ESTHER : Steadman_2022_J.Med.Chem_65_562
PubMedSearch : Steadman_2022_J.Med.Chem_65_562
PubMedID: 34939789
Gene_locus related to this paper: human-NOTUM

Title : Structural Insights into Notum Covalent Inhibition - Zhao_2021_J.Med.Chem_64_11354
Author(s) : Zhao Y , Svensson F , Steadman D , Frew S , Monaghan A , Bictash M , Moreira T , Chalk R , Lu W , Fish PV , Jones EY
Ref : Journal of Medicinal Chemistry , 64 :11354 , 2021
Abstract : Zhao_2021_J.Med.Chem_64_11354
ESTHER : Zhao_2021_J.Med.Chem_64_11354
PubMedSearch : Zhao_2021_J.Med.Chem_64_11354
PubMedID: 34292747
Gene_locus related to this paper: human-NOTUM

Title : Carboxylesterase Notum Is a Druggable Target to Modulate Wnt Signaling - Bayle_2021_J.Med.Chem__
Author(s) : Bayle ED , Svensson F , Atkinson BN , Steadman D , Willis NJ , Woodward HL , Whiting P , Vincent JP , Fish PV
Ref : Journal of Medicinal Chemistry , : , 2021
Abstract : Bayle_2021_J.Med.Chem__
ESTHER : Bayle_2021_J.Med.Chem__
PubMedSearch : Bayle_2021_J.Med.Chem__
PubMedID: 33783220
Gene_locus related to this paper: human-NOTUM

Title : Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity - Mahy_2020_J.Med.Chem_63_9464
Author(s) : Mahy W , Patel M , Steadman D , Woodward HL , Atkinson BN , Svensson F , Willis NJ , Flint A , Papatheodorou D , Zhao Y , Vecchia L , Ruza RR , Hillier J , Frew S , Monaghan A , Costa A , Bictash M , Walter MW , Jones EY , Fish PV
Ref : Journal of Medicinal Chemistry , 63 :9464 , 2020
Abstract : Mahy_2020_J.Med.Chem_63_9464
ESTHER : Mahy_2020_J.Med.Chem_63_9464
PubMedSearch : Mahy_2020_J.Med.Chem_63_9464
PubMedID: 32787107
Gene_locus related to this paper: human-NOTUM

Title : An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent - Willis_2019_Beilstein.J.Org.Chem_15_2790
Author(s) : Willis NJ , Bayle ED , Papageorgiou G , Steadman D , Atkinson BN , Mahy W , Fish PV
Ref : Beilstein J Org Chem , 15 :2790 , 2019
Abstract : Willis_2019_Beilstein.J.Org.Chem_15_2790
ESTHER : Willis_2019_Beilstein.J.Org.Chem_15_2790
PubMedSearch : Willis_2019_Beilstein.J.Org.Chem_15_2790
PubMedID: 31807213
Gene_locus related to this paper: human-NOTUM

Title : Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors - Atkinson_2019_Bioorg.Med.Chem.Lett__126751
Author(s) : Atkinson BN , Steadman D , Mahy W , Zhao Y , Sipthorp J , Bayle ED , Svensson F , Papageorgiou G , Jeganathan F , Frew S , Monaghan A , Bictash M , Jones EY , Fish PV
Ref : Bioorganic & Medicinal Chemistry Lett , :126751 , 2019
Abstract : Atkinson_2019_Bioorg.Med.Chem.Lett__126751
ESTHER : Atkinson_2019_Bioorg.Med.Chem.Lett__126751
PubMedSearch : Atkinson_2019_Bioorg.Med.Chem.Lett__126751
PubMedID: 31862412
Gene_locus related to this paper: human-NOTUM

Title : Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen - Atkinson_2019_Medchemcomm_10_1361
Author(s) : Atkinson BN , Steadman D , Zhao YG , Sipthorp J , Vecchia L , Ruza RR , Jeganathan F , Lines G , Frew S , Monaghan A , Kjaer S , Bictash M , Jones Y , Fish PV , Zhao Y , Jones EY
Ref : Medchemcomm , 10 :1361 , 2019
Abstract : Atkinson_2019_Medchemcomm_10_1361
ESTHER : Atkinson_2019_Medchemcomm_10_1361
PubMedSearch : Atkinson_2019_Medchemcomm_10_1361
PubMedID: 31534655
Gene_locus related to this paper: human-NOTUM