7SVM
Name : Human Dipeptidyl peptidase 8 (DPP8) - ICeD-2 (inducer of cell death-2) complex
Revelation date : 05-Oct-2022
Family : DPP4N_Peptidase_S9
Gene_locus : human-DPP8
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Keith P. Moore, Adam G. Schwaid et al. ICeD-1 and ICeD-2 (inducer of cell death-1 and 2) function by modulating DPP9 and activating the caspase recruitment domain family member 8 (CARD8) inflammasome, eliminating HIV-1 infected cells
References (1)
| Title : A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells - Moore_2022_ACS.Chem.Biol_17_2595 |
| Author(s) : Moore KP , Schwaid AG , Tudor M , Park S , Beshore DC , Converso A , Shipe WD , Anand R , Lan P , Moningka R , Rothman DM , Sun W , Chi A , Cornella-Taracido I , Adam GC , Bahnck-Teets C , Carroll SS , Fay JF , Goh SL , Lusen J , Quan S , Rodriguez S , Xu M , Andrews CL , Song C , Filzen T , Li J , Hollenstein K , Klein DJ , Lammens A , Lim UM , Fang Z , McHale C , Li Y , Lu M , Diamond TL , Howell BJ , Zuck P , Balibar CJ |
| Ref : ACS Chemical Biology , 17 :2595 , 2022 |
| Abstract : |
| PubMedSearch : Moore_2022_ACS.Chem.Biol_17_2595 |
| PubMedID: 36044633 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
Databases
PDB-Sum : 7SVM Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP : 7SVM Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP : 7SVM Structural Classification Of Protein - SCOP server
PROTEOPEDIA : 7SVM 3D, interactive encyclopedia of proteins - PROTEOPEDIA server