Title: High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine Oefner C, D'Arcy A, Mac Sweeney A, Pierau S, Gardiner R, Dale GE Ref: Acta Crystallographica D Biol Crystallogr, 59:1206, 2003 : PubMed
Dipeptidyl peptidase IV is a multifunctional type II transmembrane serine protease glycoprotein. The high-resolution crystal structure of the homodimeric human apo dipeptidyl peptidase IV has been determined at 1.9 A resolution. In addition, the structure of the binary complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine has been solved, revealing the nature of the covalent interaction with the active-site serine.
        
Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server
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