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Structure Report for: 3NOX

Name|Crystal structure of human DPP-IV in complex with Sa-(+)-(6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidin-2-yl)(morpholino)methanone
Revelation date|11-Aug-2010
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 182 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Meng, W., Brigance, R.P., Chao, H.J., Fura, A., Harrity, T., Marcinkeviciene, J., O`Connor, S.P., Tamura, J.K., Xie, D., Zhang, Y., Klei, H.E., Kish, K., Weigelt, C.A., Turdi, H., Wang, A., Zahler, R., Kirby, M., Hamann, L.G.
Ligand|Inhibitor: CHEMBL1214943 Ligand in structure: Ligplot


    Title: Discovery of 6-(Aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxa mides as Potent, Selective Dipeptidyl Peptidase-4 (DPP4) Inhibitors
    Meng W, Brigance RP, Chao HJ, Fura A, Harrity T, Marcinkeviciene J, O'Connor SP, Tamura JK, Xie D and Hamann LG <8 more author(s)>
    Ref: Journal of Medicinal Chemistry, 53:5620, 2010 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum3NOX Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP3NOX Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP3NOX Structural Classification Of Protein - SCOP server
PROTEOPEDIA3nox 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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