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Structure Report for: 5JAD

NameCompound binding to Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)discovered through fragment screening
Revelation date25-May-2016
FamilyPAF-Acetylhydrolase: there are 149 genes in this family, 35 structure(s)
Gene_locushuman-PLA2G7
PDB FileESTHER: header of PDB entry RCSB: Full entry
CommentDay, P.J., Woolford, A.J-A
Reference
    Title: Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening
    Woolford AJ, Pero JE, Aravapalli S, Berdini V, Coyle JE, Day PJ, Dodson AM, Grondin P, Holding FP and Xie R <19 more author(s)>
    Ref: Journal of Medicinal Chemistry, 59:5356, 2016 : PubMed

            

Ligand
Representative scheme of PAF-Acetylhydrolase structure and an image from PDBsum server
Databases
PDB-Sum5JAD Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5JAD Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5JAD Structural Classification Of Protein - SCOP server
PROTEOPEDIA5jad 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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