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Structure Report for: 5LP1

NameCrystal structure of human lipoprotein-associated phospholipase A2 in complex with a [1.1.1]bicyclopentane- containing inhibitor at 1.91 A resolution
Revelation date01-Feb-2017
FamilyPAF-Acetylhydrolase: there are 149 genes in this family, 35 structure(s)
PDB FileESTHER: header of PDB entry RCSB: Full entry
CommentSomers DO
    Title: Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor
    Measom ND, Down KD, Hirst DJ, Jamieson C, Manas ES, Patel VK, Somers DO
    Ref: ACS Med Chem Lett, 8:43, 2017 : PubMed


LigandInhibitor: 5LP1-71H Ligand in structure: Ligplot
Representative scheme of PAF-Acetylhydrolase structure and an image from PDBsum server
PDB-Sum5LP1 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5LP1 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5LP1 Structural Classification Of Protein - SCOP server
PROTEOPEDIA5lp1 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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