5-Fluorotryptophan
5-fluorotryptophan can be used as substrate analogue to study enzyme mechanisms by NMR spectroscopy. Here 5-Fluorotryptophan is considered as a substrate of dehalogenase. This compound is also used in fluorination of the tryptophan in protein sequence by supplementation with 5-fluoro-L-tryptophan during expression
General
Type : Peptide, Haloalkane
Chemical_Nomenclature : (2S)-2-amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
Canonical SMILES : C1=CC2=C(C=C1F)C(=CN2)C[C@@H](C(=O)O)N
InChI : InChI=1S\/C11H11FN2O2\/c12-7-1-2-10-8(4-7)6(5-14-10)3-9(13)11(15)16\/h1-2,4-5,9,14H,3,13H2,(H,15,16)\/t9-\/m0\/s1
InChIKey : INPQIVHQSQUEAJ-VIFPVBQESA-N
Other name(s) : 5-Fluoro-L-tryptophan || (S)-2-Amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid || L-5-fluorotryptophan || L-Tryptophan, 5-fluoro- || FTR || SCHEMBL122142 || CHEMBL559973 || DB03314 || 5-Fluoro-dl-tryptophan || 2-amino-3-(5-fluoro-1H-indol-3-yl)propanoic acid
MW : 222.22
Formula : C11H11FN2O2
CAS_number : 16626-02-1, 154-08-5
PubChem : 688357, 9577, 6921698
UniChem : INPQIVHQSQUEAJ-VIFPVBQESA-N
Target
Structures : 5K3C
Families : Haloacetate_dehalogenase
References (1)
| Title : The role of dimer asymmetry and protomer dynamics in enzyme catalysis - Kim_2017_Science_355_ |
| Author(s) : Kim TH , Mehrabi P , Ren Z , Sljoka A , Ing C , Bezginov A , Ye L , Pomes R , Prosser RS , Pai EF |
| Ref : Science , 355 : , 2017 |
| Abstract : |
| PubMedSearch : Kim_2017_Science_355_ |
| PubMedID: 28104837 |
| Gene_locus related to this paper: rhopa-q6nam1 |