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Peptide

Some naturel toxins or poisons are peptides inhibitors of alpha\/beta hydrolases (esterases lipases or peptidases). Some derivatives of amino-acids chains have been developped as inhibitors of the petidases belonging to the family
Substrate Main targeted enzyme familyes Type Structure
N-Ac-DL-MetOMe AHL-acylase Peptide Sulfur Compound
Ochratoxin-A 6_AlphaBeta_hydrolase Natural Antibiotic Peptide Propionate Toxin Chromen
Sirpiglenastat Carb_B_Chordata Pro-Drug Drug Peptide
Glutathione Bacterial_lip_FamI.1 Peptide
Thiostrepton 6_AlphaBeta_hydrolase Natural Peptide Antibiotic Macrocycle Quinoline
Mca-RPPGFSAFK(Dnp)-OH Carboxypeptidase_S10 Peptide FRET-Peptide Fluorescent Probe Coumarin
Dabcyl-EARRGLE-edans Tiancimycin-TnmK-Tripeptidase-HIP Peptide FRET-Peptide Fluorescent Probe Naphthalen
Gly-Pro-Leu-beta-NA Tiancimycin-TnmK-Tripeptidase-HIP Naphthylamide Peptide Pyrrolidine Carboxamide Naphthalen
S-bromobenzylglutathione-dicyclopentyl-ester Carb_B_Chordata Not A\/B H target Pro-Drug Drug Sulfur Compound Peptide
Omphalotin-A S9N_PPCE_Peptidase_S9 Peptide Natural Macrolide Antibiotic
Skyllamycin-A Thioesterase Peptide Natural Macrolide Antibiotic Azabicyclo
Skyllamycin-like-precursor Thioesterase Peptide Natural Macrolide Antibiotic
OphMA-core-peptide-15mer S9N_PPCE_Peptidase_S9 Peptide Macrocycle
OphMA-core-peptide-18mer S9N_PPCE_Peptidase_S9 Peptide Macrocycle
Hip1-lum Peptide Chemiluminescent Probe Fluorescent Probe Adamantyl Dioxetane
CSL174 AlphaBeta_hydrolase Peptide Fluorescent Probe Coumarin
GP-BAN DPP4N_Peptidase_S9 Fluorescent Probe Peptide
L-prolinamide Proline_iminopeptidase Carboxamide Pyrrolidine Peptide
Z-KR-pNA S9N_PREPL_Peptidase_S9 Benzyloxycarbonyl Peptide p-nitroaniline
Z-RR-pNA S9N_PREPL_Peptidase_S9 Benzyloxycarbonyl Peptide p-nitroaniline
BAPNA S9N_PREPL_Peptidase_S9 Peptide p-nitroaniline pNP
Prolyl-2-naphthylamide Carb_B_Chordata PMH_Peptidase_S9 Naphthylamide Peptide Pyrrolidine Carboxamide Naphthalen
Astexin3-dC4 ACPH_Peptidase_S9 Peptide Macrocycle
O-palmitoleoyl-L-serine Pectinacetylesterase-Notum Natural Acyl peptide
Abz-Gly-Phe-OH ACPH_Peptidase_S9 Product-like inhibitor Peptide
Phe-Ala Proline_iminopeptidase Peptide
Pro-Pro Proline_iminopeptidase Peptide Pyrrolidine
Pro-Leu-Gly-Gly Proline_iminopeptidase Peptide Pyrrolidine
Met-Ala-Ala ACPH_Peptidase_S9 Peptide Propionate
Ala-Phe Proline_iminopeptidase Peptide
Phe-Leu Proline_iminopeptidase Peptide
Abz-GLY-PHE-GLY-PRO-PHE-GLY S9N_PPCE_Peptidase_S9 Peptide
Gly-Phe-Arg-Pro S9N_PPCE_Peptidase_S9 Peptide Pyrrolidine
Gly-Phe-Glu-Pro S9N_PPCE_Peptidase_S9 Peptide Pyrrolidine
Glu-Phe-Ser-Pro S9N_PPCE_Peptidase_S9 Peptide Pyrrolidine
Alpha-amanitin-proprotein S9N_PPCE_Peptidase_S9 Natural Toxin Macrocycle Peptide
VPYGSFKHV DPP4N_Peptidase_S9 Peptide
Z-Gly-Gly-Arg-AMC S9N_PREPL_Peptidase_S9 Benzyloxycarbonyl Peptide 7-amido-4-methylcoumarin Coumarin Chromen
Bz-Arg-AMC S9N_PREPL_Peptidase_S9 Peptide 7-amido-4-methylcoumarin Coumarin Benzamine Chromen
Z-Phe-Arg-AMC S9N_PREPL_Peptidase_S9 Benzyloxycarbonyl Peptide 7-amido-4-methylcoumarin Coumarin Chromen
Z-Arg-Arg-AMC S9N_PREPL_Peptidase_S9 Benzyloxycarbonyl Peptide 7-amido-4-methylcoumarin Coumarin Chromen
Boc-Gly-Arg-Arg-AMC S9N_PREPL_Peptidase_S9 Peptide 7-amido-4-methylcoumarin Coumarin tert-Butyl Chromen
Polyaspartic-acid PolyAspartate-hydrolase Polymer Peptide
DB07813 DPP4N_Peptidase_S9 Naphthylamide Peptide Pyrrolidine Carboxamide Naphthalen
Ala-Pro-AFC Prolylcarboxypeptidase DPP4N_Peptidase_S9 Peptide Coumarin Trifluoro Pyrrolidine Carboxamide Chromen
Lys-Ala-NA Prolyl_oligopeptidase_S9 Naphthylamide Peptide Naphthalen
Ser-Tyr-NA Prolyl_oligopeptidase_S9 Naphthylamide Peptide Naphthalen
Z-Gly-Pro-pNA S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Peptide Pyrrolidine Carboxamide p-nitroaniline pNP Chromogen
Gly-Pro-pNA DPP4N_Peptidase_S9 Prolylcarboxypeptidase Lactobacillus_peptidase Peptide Pyrrolidine Carboxamide p-nitroaniline pNP Chromogen
Lys-Pro-MNA DPP4N_Peptidase_S9 Naphthylamide Peptide Pyrrolidine Carboxamide Naphthalen
His-Ser-MNA Prolyl_oligopeptidase_S9 Naphthylamide Peptide Naphthalen Propionate
Arg-Pro-pNA DPP4N_Peptidase_S9 Peptide Pyrrolidine Carboxamide p-nitroaniline pNP Chromogen
Ala-Pro-Ala-pNA Tiancimycin-TnmK-Tripeptidase-HIP Peptide Pyrrolidine Carboxamide p-nitroaniline pNP Chromogen
Ala-Pro-pNA DPP4N_Peptidase_S9 Peptide Pyrrolidine Carboxamide p-nitroaniline pNP Chromogen
Gly-Phe-pNA Prolyl_oligopeptidase_S9 DPP4N_Peptidase_S9 Peptide Carboxamide p-nitroaniline pNP Chromogen
APNE Prolyl_oligopeptidase_S9 Peptide Naphthalen Propionate
Pro-Gly-Gly PMH_Peptidase_S9 Peptide Pyrrolidine
Z-Leu-Leu-Glu-beta-naphthylamide Glutamyl_Peptidase_S9 Benzyloxycarbonyl Naphthylamide Peptide Naphthalen
H-Pro-AMC Proline_iminopeptidase Peptide Coumarin Pyrrolidine Carboxamide 7-amido-4-methylcoumarin Chromen
L-homoserine Homoserine_transacetylase Peptide Homoserine
Gly-Pro-4MbNA DPP4N_Peptidase_S9 Peptide Pyrrolidine Carboxamide Naphthalen
Gly-Pro-AMC DPP4N_Peptidase_S9 Coumarin Peptide Pyrrolidine Carboxamide 7-amido-4-methylcoumarin Chromen
S-Lactoylglutathione A85-EsteraseD-FGH Peptide
S-Formylglutathione A85-EsteraseD-FGH Antigen85c Peptide
Z-Gly-Pro-AMC S9N_PPCE_Peptidase_S9 DPP4N_Peptidase_S9 Benzyloxycarbonyl Peptide Pyrrolidine 7-amido-4-methylcoumarin Coumarin Chromen
tNPY DPP4N_Peptidase_S9 Peptide
DTS-108 Carboxylesterase Carb_B_Chordata Drug Not A\/B H target Peptide
Ac-Leu-p-nitroanilide ACPH_Peptidase_S9 Peptide p-nitroaniline pNP Chromogen
Myristoyl-ACP Thioesterase_acyl-transferase Acyl peptide
Pimeloyl-ACP-methyl-ester BioH LYsophospholipase_carboxylesterase Hormone-sensitive_lipase_like Acyl peptide
Octanoyl-ghrelin BCHE Pectinacetylesterase-Notum Acyl peptide