BrefeldinA
Purified from Penicillium brefeldianum and substrate of bacsu-brefe. Brefeldin A is a fungal metabolite which is a macrocyclic lactone exhibiting a wide range of antibiotic activity. It is a phytotoxin and pathogenicity factor from Alternaria carthami Chowdhury, the causal agent of a devastating blight disease in safflower (Carthamus tinctoriue L.). It inhibit the endoplasmic reticulum-Golgi flux
General
Type : Natural, Antibiotic, Macrocycle, Toxin
Chemical_Nomenclature : (1S,2E,7S,10E,12R,13R,15S)-12,15-dihydroxy-7-methyl-8-oxabicyclo[11.3.0]hexadeca-2,10-dien-9-one
Canonical SMILES : CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O
InChI : InChI=1S\/C16H24O4\/c1-11-5-3-2-4-6-12-9-13(17)10-14(12)15(18)7-8-16(19)20-11\/h4,6-8,11-15,17-18H,2-3,5,9-10H2,1H3\/b6-4+,8-7+\/t11-,12+,13-,14+,15+\/m0\/s1
InChIKey : KQNZDYYTLMIZCT-KQPMLPITSA-N
Other name(s) : Brefeldin A || Ascotoxin || Cyanein || Decumbin || Bredfeldin A || Synergisidin || gamma,4-Dihydroxy-2-[6-hydroxy-1heptenyl]-4-cyclopentanecrotonic acid lambda lactone
MW : 280.4
Formula : C16H24O4
CAS_number : 20350-15-6
PubChem : 5287620
UniChem : KQNZDYYTLMIZCT-KQPMLPITSA-N
Wikipedia : Brefeldin_A
Target
Structures : No structure
Families : Hormone-sensitive_lipase_like
References (1)
| Title : Molecular characterization and cloning of an esterase which inactivates the macrolide toxin brefeldin A - Kneusel_1994_J.Biol.Chem_269_3449 |
| Author(s) : Kneusel RE , Schiltz E , Matern U |
| Ref : Journal of Biological Chemistry , 269 :3449 , 1994 |
| Abstract : |
| PubMedSearch : Kneusel_1994_J.Biol.Chem_269_3449 |
| PubMedID: 8106385 |
| Gene_locus related to this paper: bacsu-brefe |