CHEMBL1784957
Carbamate cholinesterase inhibitor. Conjugation of the phenol derived from rivastigmine with d-amphetamine
General
Type : Drug, Pro-Drug, Carbamate, Derivative of Rivastigmine
Chemical_Nomenclature : [3-[(1S)-1-(dimethylamino)ethyl]phenyl] N-[(2S)-1-phenylpropan-2-yl]carbamate
Canonical SMILES : CC(CC1=CC=CC=C1)NC(=O)OC2=CC=CC(=C2)C(C)N(C)C
InChI : InChI=1S\/C20H26N2O2\/c1-15(13-17-9-6-5-7-10-17)21-20(23)24-19-12-8-11-18(14-19)16(2)22(3)4\/h5-12,14-16H,13H2,1-4H3,(H,21,23)\/t15-,16-\/m0\/s1
InChIKey : HKJROXHSAHRDAO-HOTGVXAUSA-N
Other name(s) : CHEMBL1784957 || SCHEMBL7897597 || CHEMBL1789758 || BDBM50345811 || 3-((S)-1-(dimethylamino)ethyl)phenyl(S)-1-phenylpropan-2-ylcarbamate hydrochloride
MW : 326.4
Formula : C20H26N2O2
CAS_number :
PubChem : 25205011
UniChem : HKJROXHSAHRDAO-HOTGVXAUSA-N
Target
Structures : No structure
Families : ACHE
References (1)
| Title : Novel carbamate cholinesterase inhibitors that release biologically active amines following enzyme inhibition - Verheijen_2009_Bioorg.Med.Chem.Lett_19_3243 |
| Author(s) : Verheijen JC , Wiig KA , Du S , Connors SL , Martin AN , Ferreira JP , Slepnev VI , Kochendorfer U |
| Ref : Bioorganic & Medicinal Chemistry Lett , 19 :3243 , 2009 |
| Abstract : |
| PubMedSearch : Verheijen_2009_Bioorg.Med.Chem.Lett_19_3243 |
| PubMedID: 19423342 |