Carbamate

Derived from carbamic acid (NH2COOH). Polymers whose units are joined by divalent carbamate groups NH(C=O)O are an important family of plastics, the polyurethanes. Carbamates can also inhibits many enzymes whose catalytic active site contains a nucleophilic Serine. This serine can be carbamylated. The first naturally occurring carbamate discovered was physostigmeine( eserine). Many carbamates were developped as insecticides or nerve agents (inhibitors of cholinesterases) but also in medicine
Substrate Main targeted enzyme families Type Structure
Chlorpropham Carb_B_Bacteria HNLyase_Bact Carbamate Herbicide
Desmedipham Carb_B_Bacteria Carbamate Herbicide
Phenmedipham Carb_B_Bacteria Carbamate Herbicide
Indoxacarb Carb_B_Arthropoda Insecticide Carboxamide Carbamate Trifluoro Not A\/B H target
Carbendazim HNLyase_Bact Carbamate Benzimidazole
Flupirtine Carb_B_Chordata Pro-Drug Drug Not A\/B H target Carbamate
Idalopirdine-rivastigmine BCHE Drug Pro-Drug Indole Carbamate Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand
CHEMBL1784957 ACHE Drug Pro-Drug Carbamate Derivative of Rivastigmine
1-Cbz-pyrrolidine Epoxide_hydrolase Epoxide Benzyloxycarbonyl Carbamate
Chlorantraniliprole Insecticide Carbamate Pyridine Carboxamide Pyrazole
Eslicarbazepine-acetate Carb_B_Chordata Arylacetamide_deacetylase Drug Pro-Drug Benzazepin Carbamate Acetate Carboxamide Azepane
trans-Bifenthrin HNLyase_Bact Carb_B_Arthropoda Pyrethroid Insecticide Trifluoro Not A\/B H target Carbamate Cyclopropyl
Polyurethane Carb_B_Bacteria Polyesterase-lipase-cutinase Bacterial_lip_FamI.3 Cutinase Polymer Carbamate Polyurethane
Tosylcarbamic-acid-butyl-ester Sulfonamide Sulfur Compound Carbamate Polyurethane
Fenobucarb ACHE Hormone-sensitive_lipase_like Insecticide Carbamate
Carbachol ACHE Drug Not A\/B H target Carbamate Trimethylammonium Choline ester Analogue of substrate
NPC Carb_B_Bacteria Carbamate Drug Derivative of Irinotecan Not A\/B H target Piperidine
SNCN-AE ACHE Near-Infrared fluorescent Probe Fluorescent Probe Carbamate Benzothiazol
TQ-AChE ACHE Near-Infrared fluorescent Probe Fluorescent Probe Carbamate Benzothiazol
Irinotecan Carb_B_Chordata BCHE Carb_B_Bacteria Carbamate Drug Derivative of Irinotecan
Bambuterol BCHE Pro-Drug Drug Carbamate tert-Butyl Adrenergic-Receptor-ligand
N-Methyl-7-dimethylcarbamoxyquinolinium ACHE Carbamate Quinoline
butyl-N(para-nitrophenyl)carbamate Cutinase Carbamate Polyurethane pNP Chromogen
Paranitrophenyl-N-benzylcarbamate Cutinase Carbamate Polyurethane pNP Chromogen
Capecitabine Carboxylesterase Carb_B_Chordata Drug Carbamate Pyrimidine Pro-Drug