Candesartan-cilexetil
Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is administered orally as the prodrug, candesartan cilexetil, which is rapidly converted to its active metabolite, candesartan. Hydrolyzed by CES1 but not by CES2
General
Type : Not AlphaBeta Hydrolase target, Drug, Pro-Drug, Pyrrolidine, Angiotensin-receptor blocker, Benzimidazole
Chemical_Nomenclature : 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
Canonical SMILES : CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC(C)OC(=O)OC6CCCCC6
InChI : InChI=1S\/C33H34N6O6\/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30\/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)
InChIKey : GHOSNRCGJFBJIB-UHFFFAOYSA-N
Other name(s) : Candesartan cilexetil || Atacand || TCV-116 || Blopress || CC || CHEMBL1014 || CHEBI:3348
MW : 610.7
Formula : C33H34N6O6
CAS_number : 145040-37-5
PubChem : 2540
UniChem : GHOSNRCGJFBJIB-UHFFFAOYSA-N
Target
Structures : No structure
Families : Carb_B_Chordata
References (3)
| Title : Physiologically based pharmacokinetic modeling of candesartan to predict the exposure in hepatic and renal impairment and elderly populations - Guo_2023_Ther.Adv.Drug.Saf_14_20420986231220222 |
| Author(s) : Guo L , Zhu X , Zhang L , Xu Y |
| Ref : Ther Adv Drug Safety , 14 :20420986231220222 , 2023 |
| Abstract : |
| PubMedSearch : Guo_2023_Ther.Adv.Drug.Saf_14_20420986231220222 |
| PubMedID: 38157240 |
| Title : Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs - Nishimuta_2014_Drug.Metab.Dispos_42_1522 |
| Author(s) : Nishimuta H , Houston JB , Galetin A |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :1522 , 2014 |
| Abstract : |
| PubMedSearch : Nishimuta_2014_Drug.Metab.Dispos_42_1522 |
| PubMedID: 24994071 |
| Title : Different hydrolases involved in bioactivation of prodrug-type Angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1 - Ishizuka_2013_Drug.Metab.Dispos_41_1888 |
| Author(s) : Ishizuka T , Yoshigae Y , Murayama N , Izumi T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1888 , 2013 |
| Abstract : |
| PubMedSearch : Ishizuka_2013_Drug.Metab.Dispos_41_1888 |
| PubMedID: 23946449 |