DDAO-ol
not substrate of porcine pancreatic lipase (pPL), albumin (hSA), lysozyme carboxylesterase CES1 CES2, AChE, BChE, thrombin, carbonic anhydrase (CA), -glucosidase, -amylase, cathepsin-A, plasmin, pepsin, trypsin, lpha-chymotrypsin , dipeptidyl peptidase-IV (DPP-IV)
General
Type : Acridine, Fatty acid ester, Water-insoluble medium and long chain ester, Oleate, Fluorescent Probe, Near-Infrared fluorescent Probe
Chemical_Nomenclature : 9H-1,3-Dichloro-7-oleoyl-9,9-dimethylacridine-2-one
Canonical SMILES : C1(=CC=C3C(=C1)C(C2=C(C(C(=CC2=N3)Cl)=O)Cl)(C)C)OC(CCCCCCCC=CCCCCCCCC)=O
InChI : InChI=1S\/C33H43Cl2NO3\/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-29(37)39-24-20-21-27-25(22-24)33(2,3)30-28(36-27)23-26(34)32(38)31(30)35\/h11-12,20-23H,4-10,13-19H2,1-3H3
InChIKey : GBTBZVCBMXRHOM-UHFFFAOYSA-N
Other name(s) :
Target
Structures : No structure
Families : Pancreatic_lipase
References (2)
| Title : Discovery of natural anthraquinones as potent inhibitors against pancreatic lipase: structure-activity relationships and inhibitory mechanism - Chen_2024_J.Enzyme.Inhib.Med.Chem_39_2398561 |
| Author(s) : Chen ZQ , He WY , Yang SY , Ma HH , Zhou J , Li H , Zhu YD , Qian XK , Zou LW |
| Ref : J Enzyme Inhib Med Chem , 39 :2398561 , 2024 |
| Abstract : |
| PubMedSearch : Chen_2024_J.Enzyme.Inhib.Med.Chem_39_2398561 |
| PubMedID: 39223707 |
| Title : Rational design and development of a novel and highly specific near-infrared fluorogenic substrate for sensing and imaging of human pancreatic lipase in living systems - Hu_2021_Sens.Actuators.B.Chem_341_130033 |
| Author(s) : Hu Q , Tian ZH , Wang HN , Huang J , Wang FY , Zhao B , He RJ , Jin Q , Hou XD , Hou J , Fang SQ , Wang P , Ge GB |
| Ref : Sensors and Actuators B: Chemical , 341 :130033 , 2021 |
| Abstract : |
| PubMedSearch : Hu_2021_Sens.Actuators.B.Chem_341_130033 |
| PubMedID: |