Fluoroacetate
Fluoroacetate is a naturally occurring organofluorine compound. An actinomycete,(Streptomyces cattleya), and some plants in Australia and Africa produce this highly toxic compound. Fluoroacetate dehalogenases from Burkholderia sp and Delftia acidovorans catalyze the hydrolytic defluorination of fluoroacetate to produce glycolate. These enzymes are unique in that they catalyze the cleavage of the carbon-fluorine bond, whose dissociation energy is among the highest found in nature. Fluoroacetate is a poison developped as rodenticide
General
Type : Haloacetate, Acetate
Chemical_Nomenclature : 2-fluoroacetate
Canonical SMILES : C(C(=O)[O-])F
InChI : InChI=1S\/C2H3FO2\/c3-1-2(4)5\/h1H2,(H,4,5)\/p-1
InChIKey : QEWYKACRFQMRMB-UHFFFAOYSA-M
Other name(s) : FCH2CO2 anion || 2-fluoroacetate || Cymoric acid || Alpha-fluoroacetic acid || Monofluoroacetate || MFA
MW : 77.03
Formula : C2H2FO2-
CAS_number : 513-62-2
PubChem : 5236
UniChem : QEWYKACRFQMRMB-UHFFFAOYSA-M
Wikipedia : Fluoroacetic_acid
References (18)
| Title : Time-resolved crystallography reveals allosteric communication aligned with molecular breathing - Mehrabi_2019_Science_365_1167 |
| Author(s) : Mehrabi P , Schulz EC , Dsouza R , Muller-Werkmeister HM , Tellkamp F , Miller RJD , Pai EF |
| Ref : Science , 365 :1167 , 2019 |
| Abstract : |
| PubMedSearch : Mehrabi_2019_Science_365_1167 |
| PubMedID: 31515393 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : Substrate-Based Allosteric Regulation of a Homodimeric Enzyme - Mehrabi_2019_J.Am.Chem.Soc_141_11540 |
| Author(s) : Mehrabi P , Di Pietrantonio C , Kim TH , Sljoka A , Taverner K , Ing C , Kruglyak N , Pomes R , Pai EF , Prosser RS |
| Ref : Journal of the American Chemical Society , 141 :11540 , 2019 |
| Abstract : |
| PubMedSearch : Mehrabi_2019_J.Am.Chem.Soc_141_11540 |
| PubMedID: 31188575 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : Time-resolved crystallography reveals allosteric communication aligned with molecular breathing - Mehrabi_2019_Science_365_1167 |
| Author(s) : Mehrabi P , Schulz EC , Dsouza R , Muller-Werkmeister HM , Tellkamp F , Miller RJD , Pai EF |
| Ref : Science , 365 :1167 , 2019 |
| Abstract : |
| PubMedSearch : Mehrabi_2019_Science_365_1167 |
| PubMedID: 31515393 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : Substrate-Based Allosteric Regulation of a Homodimeric Enzyme - Mehrabi_2019_J.Am.Chem.Soc_141_11540 |
| Author(s) : Mehrabi P , Di Pietrantonio C , Kim TH , Sljoka A , Taverner K , Ing C , Kruglyak N , Pomes R , Pai EF , Prosser RS |
| Ref : Journal of the American Chemical Society , 141 :11540 , 2019 |
| Abstract : |
| PubMedSearch : Mehrabi_2019_J.Am.Chem.Soc_141_11540 |
| PubMedID: 31188575 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : Time-resolved crystallography reveals allosteric communication aligned with molecular breathing - Mehrabi_2019_Science_365_1167 |
| Author(s) : Mehrabi P , Schulz EC , Dsouza R , Muller-Werkmeister HM , Tellkamp F , Miller RJD , Pai EF |
| Ref : Science , 365 :1167 , 2019 |
| Abstract : |
| PubMedSearch : Mehrabi_2019_Science_365_1167 |
| PubMedID: 31515393 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : Substrate-Based Allosteric Regulation of a Homodimeric Enzyme - Mehrabi_2019_J.Am.Chem.Soc_141_11540 |
| Author(s) : Mehrabi P , Di Pietrantonio C , Kim TH , Sljoka A , Taverner K , Ing C , Kruglyak N , Pomes R , Pai EF , Prosser RS |
| Ref : Journal of the American Chemical Society , 141 :11540 , 2019 |
| Abstract : |
| PubMedSearch : Mehrabi_2019_J.Am.Chem.Soc_141_11540 |
| PubMedID: 31188575 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : The hit-and-return system enables efficient time-resolved serial synchrotron crystallography - Schulz_2018_Nat.Methods_15_901 |
| Author(s) : Schulz EC , Mehrabi P , Muller-Werkmeister HM , Tellkamp F , Jha A , Stuart W , Persch E , De Gasparo R , Diederich F , Pai EF , Miller RJD |
| Ref : Nat Methods , 15 :901 , 2018 |
| Abstract : |
| PubMedSearch : Schulz_2018_Nat.Methods_15_901 |
| PubMedID: 30377366 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : The hit-and-return system enables efficient time-resolved serial synchrotron crystallography - Schulz_2018_Nat.Methods_15_901 |
| Author(s) : Schulz EC , Mehrabi P , Muller-Werkmeister HM , Tellkamp F , Jha A , Stuart W , Persch E , De Gasparo R , Diederich F , Pai EF , Miller RJD |
| Ref : Nat Methods , 15 :901 , 2018 |
| Abstract : |
| PubMedSearch : Schulz_2018_Nat.Methods_15_901 |
| PubMedID: 30377366 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : The hit-and-return system enables efficient time-resolved serial synchrotron crystallography - Schulz_2018_Nat.Methods_15_901 |
| Author(s) : Schulz EC , Mehrabi P , Muller-Werkmeister HM , Tellkamp F , Jha A , Stuart W , Persch E , De Gasparo R , Diederich F , Pai EF , Miller RJD |
| Ref : Nat Methods , 15 :901 , 2018 |
| Abstract : |
| PubMedSearch : Schulz_2018_Nat.Methods_15_901 |
| PubMedID: 30377366 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : The role of dimer asymmetry and protomer dynamics in enzyme catalysis - Kim_2017_Science_355_ |
| Author(s) : Kim TH , Mehrabi P , Ren Z , Sljoka A , Ing C , Bezginov A , Ye L , Pomes R , Prosser RS , Pai EF |
| Ref : Science , 355 : , 2017 |
| Abstract : |
| PubMedSearch : Kim_2017_Science_355_ |
| PubMedID: 28104837 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : The role of dimer asymmetry and protomer dynamics in enzyme catalysis - Kim_2017_Science_355_ |
| Author(s) : Kim TH , Mehrabi P , Ren Z , Sljoka A , Ing C , Bezginov A , Ye L , Pomes R , Prosser RS , Pai EF |
| Ref : Science , 355 : , 2017 |
| Abstract : |
| PubMedSearch : Kim_2017_Science_355_ |
| PubMedID: 28104837 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : The role of dimer asymmetry and protomer dynamics in enzyme catalysis - Kim_2017_Science_355_ |
| Author(s) : Kim TH , Mehrabi P , Ren Z , Sljoka A , Ing C , Bezginov A , Ye L , Pomes R , Prosser RS , Pai EF |
| Ref : Science , 355 : , 2017 |
| Abstract : |
| PubMedSearch : Kim_2017_Science_355_ |
| PubMedID: 28104837 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery. - Moynie_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_25 |
| Author(s) : Moynie L , Schnell R , McMahon SA , Sandalova T , Boulkerou WA , Schmidberger JW , Alphey M , Cukier C , Duthie F , Kopec J , Liu H , Jacewicz A , Hunter WN , Naismith JH , Schneider G |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 69 :25 , 2013 |
| Abstract : |
| PubMedSearch : Moynie_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_25 |
| PubMedID: 23295481 |
| Gene_locus related to this paper: pseae-PA2086 |
| Title : The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery. - Moynie_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_25 |
| Author(s) : Moynie L , Schnell R , McMahon SA , Sandalova T , Boulkerou WA , Schmidberger JW , Alphey M , Cukier C , Duthie F , Kopec J , Liu H , Jacewicz A , Hunter WN , Naismith JH , Schneider G |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 69 :25 , 2013 |
| Abstract : |
| PubMedSearch : Moynie_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_25 |
| PubMedID: 23295481 |
| Gene_locus related to this paper: pseae-PA2086 |
| Title : The AEROPATH project targeting Pseudomonas aeruginosa: crystallographic studies for assessment of potential targets in early-stage drug discovery. - Moynie_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_25 |
| Author(s) : Moynie L , Schnell R , McMahon SA , Sandalova T , Boulkerou WA , Schmidberger JW , Alphey M , Cukier C , Duthie F , Kopec J , Liu H , Jacewicz A , Hunter WN , Naismith JH , Schneider G |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 69 :25 , 2013 |
| Abstract : |
| PubMedSearch : Moynie_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_25 |
| PubMedID: 23295481 |
| Gene_locus related to this paper: pseae-PA2086 |
| Title : Mapping the reaction coordinates of enzymatic defluorination - Chan_2011_J.Am.Chem.Soc_133_7461 |
| Author(s) : Chan PW , Yakunin AF , Edwards EA , Pai EF |
| Ref : Journal of the American Chemical Society , 133 :7461 , 2011 |
| Abstract : |
| PubMedSearch : Chan_2011_J.Am.Chem.Soc_133_7461 |
| PubMedID: 21510690 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : Mapping the reaction coordinates of enzymatic defluorination - Chan_2011_J.Am.Chem.Soc_133_7461 |
| Author(s) : Chan PW , Yakunin AF , Edwards EA , Pai EF |
| Ref : Journal of the American Chemical Society , 133 :7461 , 2011 |
| Abstract : |
| PubMedSearch : Chan_2011_J.Am.Chem.Soc_133_7461 |
| PubMedID: 21510690 |
| Gene_locus related to this paper: rhopa-q6nam1 |
| Title : Mapping the reaction coordinates of enzymatic defluorination - Chan_2011_J.Am.Chem.Soc_133_7461 |
| Author(s) : Chan PW , Yakunin AF , Edwards EA , Pai EF |
| Ref : Journal of the American Chemical Society , 133 :7461 , 2011 |
| Abstract : |
| PubMedSearch : Chan_2011_J.Am.Chem.Soc_133_7461 |
| PubMedID: 21510690 |
| Gene_locus related to this paper: rhopa-q6nam1 |