HD56
HD561, which was designed to enhance nerve growth (targeting FK506 binding proteins) , was re-engineered into HD56, a carboxylic acid ester prodrug HD56 targeting FK506 binding proteins
General
Type : Sulfur Compound, Sulfonamide, Morpholine, Drug, Pro-Drug
Chemical_Nomenclature : propan-2-yl (2R)-4-methyl-2-[[(3R)-4-(4-methylphenyl)sulfonylthiomorpholine-3-carbonyl]amino]pentanoate
Canonical SMILES : CC1=CC=C(C=C1)S(=O)(=O)N2CCSC[C@H]2C(=O)N[C@H](CC(C)C)C(=O)OC(C)C
InChI : InChI=1S\/C21H32N2O5S2\/c1-14(2)12-18(21(25)28-15(3)4)22-20(24)19-13-29-11-10-23(19)30(26,27)17-8-6-16(5)7-9-17\/h6-9,14-15,18-19H,10-13H2,1-5H3,(H,22,24)\/t18-,19+\/m1\/s1
InChIKey : CKYLCNCYPUJLOL-MOPGFXCFSA-N
Other name(s) : SCHEMBL16857183 || Unk(Tos)Cys-dLeu-OiPr
MW : 456.6
Formula : C21H32N2O5S2
CAS_number :
PubChem : 71509765
UniChem : CKYLCNCYPUJLOL-MOPGFXCFSA-N
Target
Structures : No structure
Families : Carb_B_Chordata
References (3)
| Title : Species-specific in vivo exposure assessment and in vivo-in vitro correlation of the carboxylate esters prodrug HD56 targeting FK506 binding proteins: The pivotal role of humanized mice - Yang_2025_Drug.Metab.Dispos_53_100049 |
| Author(s) : Yang M , Yao S , Zhang W , Zhao T , Li C , Ai H , Wu X , Xiao J , Zhuang X |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 53 :100049 , 2025 |
| Abstract : |
| PubMedSearch : Yang_2025_Drug.Metab.Dispos_53_100049 |
| PubMedID: 40073534 |
| Gene_locus related to this paper: human-CES1 |
| Title : Species-specific in vivo exposure assessment and in vivo-in vitro correlation of the carboxylate esters prodrug HD56 targeting FK506 binding proteins: The pivotal role of humanized mice - Yang_2025_Drug.Metab.Dispos_53_100049 |
| Author(s) : Yang M , Yao S , Zhang W , Zhao T , Li C , Ai H , Wu X , Xiao J , Zhuang X |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 53 :100049 , 2025 |
| Abstract : |
| PubMedSearch : Yang_2025_Drug.Metab.Dispos_53_100049 |
| PubMedID: 40073534 |
| Gene_locus related to this paper: human-CES1 |
| Title : Species-specific in vivo exposure assessment and in vivo-in vitro correlation of the carboxylate esters prodrug HD56 targeting FK506 binding proteins: The pivotal role of humanized mice - Yang_2025_Drug.Metab.Dispos_53_100049 |
| Author(s) : Yang M , Yao S , Zhang W , Zhao T , Li C , Ai H , Wu X , Xiao J , Zhuang X |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 53 :100049 , 2025 |
| Abstract : |
| PubMedSearch : Yang_2025_Drug.Metab.Dispos_53_100049 |
| PubMedID: 40073534 |
| Gene_locus related to this paper: human-CES1 |