Laninamivir-octanoate
Laninamivir octanoate has been used in trials studying the treatment of Asthma. A Long-Acting Neuraminidase Inhibitor, Shows Anti-Influenza Virus Activity
General
Type : Fatty acid ester, Water-insoluble medium and long chain ester, Pro-Drug, Drug, Not AlphaBeta Hydrolase target, Octanoate
Chemical_Nomenclature : (2R,3R,4S)-3-acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-2-hydroxy-1-methoxy-3-octanoyloxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
Canonical SMILES : CCCCCCCC(=O)OC[C@H]([C@H]([C@H]1[C@@H]([C@H](C=C(O1)C(=O)O)N=C(N)N)NC(=O)C)OC)O
InChI : InChI=1S\/C21H36N4O8\/c1-4-5-6-7-8-9-16(28)32-11-14(27)18(31-3)19-17(24-12(2)26)13(25-21(22)23)10-15(33-19)20(29)30\/h10,13-14,17-19,27H,4-9,11H2,1-3H3,(H,24,26)(H,29,30)(H4,22,23,25)\/t13-,14+,17+,18+,19+\/m0\/s1
InChIKey : UKTIJASCFRNWCB-RMIBSVFLSA-N
Other name(s) : Laninamivir octanoate || E026V904RL || R-118958 || Laninamivir octanoic acid ester || RefChem:152255 || CHEMBL467058 || SCHEMBL11024932 || SCHEMBL29388954 || CHEBI:134741 || DB11888 || CS-8958
MW : 472.5
Formula : C21H36N4O8
CAS_number : 203120-46-1
PubChem : 9847629
UniChem : UKTIJASCFRNWCB-RMIBSVFLSA-N
Target
Structures : No structure
Families : A85-EsteraseD-FGH
References (1)
| Title : CS-8958, a prodrug of the novel neuraminidase inhibitor R-125489, demonstrates a favorable long-retention profile in the mouse respiratory tract - Koyama_2009_Antimicrob.Agents.Chemother_53_4845 |
| Author(s) : Koyama K , Takahashi M , Oitate M , Nakai N , Takakusa H , Miura S , Okazaki O |
| Ref : Antimicrobial Agents & Chemotherapy , 53 :4845 , 2009 |
| Abstract : |
| PubMedSearch : Koyama_2009_Antimicrob.Agents.Chemother_53_4845 |
| PubMedID: 19687241 |