Mca-RPPGFSAFK(Dnp)-OH
peptide derivative of bradykinine: substrate for angiotensine converting enzymz (ACE), and active Cathepsin A and X/Z/P, endothelin-converting enzyme-1 (ECE-1) and neprilysin. Mca fluorescence is quenched by the Dnp group until cleavage separates them.
General
Type : Peptide, FRET-Peptide, Fluorescent Probe, Coumarin
Chemical_Nomenclature :
Canonical SMILES :
InChI :
InChIKey :
Other name(s) : 7-methoxycoumarin-4-yl)acetyl-RPPGFSAFK(2,4-dinitrophenyl)-OH || Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH
-OH.gif)
Target
Structures : No structure
Families : Carboxypeptidase_S10
References (1)
| Title : Structural and Kinetic Evidence of Aging after Organophosphate Inhibition of Human Cathepsin A - Bouknight_2020_Biochem.Pharmacol__113980 |
| Author(s) : Bouknight KD , Jurkouich KM , Compton JR , Khavrutskii IV , Guelta MA , Harvey SP , Legler PM |
| Ref : Biochemical Pharmacology , :113980 , 2020 |
| Abstract : |
| PubMedSearch : Bouknight_2020_Biochem.Pharmacol__113980 |
| PubMedID: 32305437 |
| Gene_locus related to this paper: human-CTSA |