Carboxypeptidase_S10
Relationship
Comment
Serine carboxypeptidase-like (SCPL) proteins. Structures determined for wheat and yeast peptidase first. Very successful family in plants (arabdopsis) also human protective protein cathepsineA. The protective protein human-CTSA is a glycoprotein that associates with lysosomal beta-galactosidase and neuraminidase and is deficient in the autosomal recessive disorder Galactosialidosis . Also contains non peptidase sequences as hydroxynitril lyase from plants. But new structure of sorghum hnl shows clear differences in catalytic mechanism because of a deletion of two amino acid adjescent of the active site serine: see sorbi-hnl and 1GXS Lauble et al 2002. It does not accept aliphatic hydroxynitriles, unlike EC 4.1.2.10 mandelonitrile lyase and EC 4.1.2.39 hydroxynitrilase. Other hydroxynitril lyase belong to another family: Hydroxynitrile_lyase . This Carboxypeptidase family also contains acyltransferases as sinapoyltransferase AT2G22990 arath-SCP8 SNG1 gene. Another enzyme, related to the SCPL family, is glucose acyltransferase from Lycopersicon pennellii catalysing the formation of diacylglucose. Some of these SCPL have a T instead of the serine in the catalytic triad: probably no catalytic activity but partner of another Serine carboxypeptitase-like protein.
Database
Interpro : IPR001563 Peptidase S10, serine carboxypeptidase
PIRSF : No PIRSF
Pdoc : PDOC00122
Pfam : PF00450 Peptidase_S10
Prints : PR00724
EC Number : 3.4.16.6 || 4.1.2.11
Structures (20)
Genes Proteins in Carboxypeptidase_S10 family (619)
Fragments of genes in Carboxypeptidase_S10 family (87)
Structures in Carboxypeptidase_S10 family (20)Substrates in Carboxypeptidase_S10 family (4)
Inhibitors in Carboxypeptidase_S10 family (16)
References (21)
| Title : Insights into acylation mechanisms: co-expression of serine carboxypeptidase-like acyltransferases and their non-catalytic companion paralogs - Yao_2022_Plant.J_111_117 |
| Author(s) : Yao S , Liu Y , Zhuang J , Zhao Y , Dai X , Jiang C , Wang Z , Jiang X , Zhang S , Qian Y , Tai Y , Wang Y , Wang H , Xie DY , Gao L , Xia T |
| Ref : Plant J , 111 :117 , 2022 |
| Abstract : Yao_2022_Plant.J_111_117 |
| ESTHER : Yao_2022_Plant.J_111_117 |
| PubMedSearch : Yao_2022_Plant.J_111_117 |
| PubMedID: 35437852 |
| Gene_locus related to this paper: dioka-dkSCPL1 , camsi-SCPL5 , camsi-SCPL4 |
| Title : Crystal structure of cathepsin A, a novel target for the treatment of cardiovascular diseases - Schreuder_2014_Biochem.Biophys.Res.Commun_445_451 |
| Author(s) : Schreuder HA , Liesum A , Kroll K , Bohnisch B , Buning C , Ruf S , Sadowski T |
| Ref : Biochemical & Biophysical Research Communications , 445 :451 , 2014 |
| Abstract : Schreuder_2014_Biochem.Biophys.Res.Commun_445_451 |
| ESTHER : Schreuder_2014_Biochem.Biophys.Res.Commun_445_451 |
| PubMedSearch : Schreuder_2014_Biochem.Biophys.Res.Commun_445_451 |
| PubMedID: 24530914 |
| Gene_locus related to this paper: human-CTSA |
| Title : Proteolytic activation of human cathepsin A - Kolli_2014_J.Biol.Chem_289_11592 |
| Author(s) : Kolli N , Garman SC |
| Ref : Journal of Biological Chemistry , 289 :11592 , 2014 |
| Abstract : Kolli_2014_J.Biol.Chem_289_11592 |
| ESTHER : Kolli_2014_J.Biol.Chem_289_11592 |
| PubMedSearch : Kolli_2014_J.Biol.Chem_289_11592 |
| PubMedID: 24599961 |
| Gene_locus related to this paper: human-CTSA |
| Title : Novel beta-amino acid derivatives as inhibitors of cathepsin A. - Ruf_2012_J.Med.Chem_55_7636 |
| Author(s) : Ruf S , Buning C , Schreuder H , Horstick G , Linz W , Olpp T , Pernerstorfer J , Hiss K , Kroll K , Kannt A , Kohlmann M , Linz D , Hubschle T , Rutten H , Wirth K , Schmidt T , Sadowski T |
| Ref : Journal of Medicinal Chemistry , 55 :7636 , 2012 |
| Abstract : Ruf_2012_J.Med.Chem_55_7636 |
| ESTHER : Ruf_2012_J.Med.Chem_55_7636 |
| PubMedSearch : Ruf_2012_J.Med.Chem_55_7636 |
| PubMedID: 22861813 |
| Gene_locus related to this paper: human-CTSA |
| Title : Structure determinants and substrate recognition of serine carboxypeptidase-like acyltransferases from plant secondary metabolism - Stehle_2006_FEBS.Lett_580_6366 |
| Author(s) : Stehle F , Brandt W , Milkowski C , Strack D |
| Ref : FEBS Letters , 580 :6366 , 2006 |
| Abstract : Stehle_2006_FEBS.Lett_580_6366 |
| ESTHER : Stehle_2006_FEBS.Lett_580_6366 |
| PubMedSearch : Stehle_2006_FEBS.Lett_580_6366 |
| PubMedID: 17094968 |
| Gene_locus related to this paper: arath-SCP19 , arath-SCP8 |
| Title : Structure of the carboxypeptidase Y inhibitor IC in complex with the cognate proteinase reveals a novel mode of the proteinase-protein inhibitor interaction - Mima_2005_J.Mol.Biol_346_1323 |
| Author(s) : Mima J , Hayashida M , Fujii T , Narita Y , Hayashi R , Ueda M , Hata Y |
| Ref : Journal of Molecular Biology , 346 :1323 , 2005 |
| Abstract : Mima_2005_J.Mol.Biol_346_1323 |
| ESTHER : Mima_2005_J.Mol.Biol_346_1323 |
| PubMedSearch : Mima_2005_J.Mol.Biol_346_1323 |
| PubMedID: 15713484 |
| Gene_locus related to this paper: yeast-cbpy1 |
| Title : An expression and bioinformatics analysis of the Arabidopsis serine carboxypeptidase-like gene family - Fraser_2005_Plant.Physiol_138_1136 |
| Author(s) : Fraser CM , Rider LW , Chapple C |
| Ref : Plant Physiol , 138 :1136 , 2005 |
| Abstract : Fraser_2005_Plant.Physiol_138_1136 |
| ESTHER : Fraser_2005_Plant.Physiol_138_1136 |
| PubMedSearch : Fraser_2005_Plant.Physiol_138_1136 |
| PubMedID: 15908604 |
| Gene_locus related to this paper: arath-AT4g30610 , arath-SCP25 , arath-SCP27 , arath-SCP16 , arath-SCP4 , arath-SCP7 , arath-SCP8 , arath-SCP11 , arath-SCP15 , arath-SCP18 , arath-SCP23 , arath-SCP26 , arath-SCP28 , arath-SCP32 , arath-SCP33 , arath-SCP36 , arath-SCP40 , arath-SCP44 , arath-SCPL6 , arath-SCPL34 , arath-SCP22 |
| Title : Serine carboxypeptidase-like acyltransferases - Milkowski_2004_Phytochemistry_65_517 |
| Author(s) : Milkowski C , Strack D |
| Ref : Phytochemistry , 65 :517 , 2004 |
| Abstract : Milkowski_2004_Phytochemistry_65_517 |
| ESTHER : Milkowski_2004_Phytochemistry_65_517 |
| PubMedSearch : Milkowski_2004_Phytochemistry_65_517 |
| PubMedID: 15003414 |
| Gene_locus related to this paper: arath-SCP8 |
| Title : Bifunctional indole-3-acetyl transferase catalyses synthesis and hydrolysis of indole-3-acetyl-myo-inositol in immature endosperm of Zea mays - Kowalczyk_2003_Physiol.Plant_119_165 |
| Author(s) : Kowalczyk S , Jakubowska A , Zielieska E , Bandurski RS |
| Ref : Physiologica Plantarum , 119 :165 , 2003 |
| Abstract : Kowalczyk_2003_Physiol.Plant_119_165 |
| ESTHER : Kowalczyk_2003_Physiol.Plant_119_165 |
| PubMedSearch : Kowalczyk_2003_Physiol.Plant_119_165 |
| PubMedID: |
| Gene_locus related to this paper: maize-b4fg76 |
| Title : Increased proteolytic susceptibility of carboxypeptidase Y caused by modification of the disulfide zipper - Maki_2002_Biosci.Biotechnol.Biochem_66_1393 |
| Author(s) : Maki T , Kozawa H , Mima J , Ueno H , Hayashi R |
| Ref : Biosci Biotechnol Biochem , 66 :1393 , 2002 |
| Abstract : Maki_2002_Biosci.Biotechnol.Biochem_66_1393 |
| ESTHER : Maki_2002_Biosci.Biotechnol.Biochem_66_1393 |
| PubMedSearch : Maki_2002_Biosci.Biotechnol.Biochem_66_1393 |
| PubMedID: 12162566 |
| Gene_locus related to this paper: yeast-cbpy1 |
| Title : Crystal structure of hydroxynitrile lyase from Sorghum bicolor in complex with the inhibitor benzoic acid: a novel cyanogenic enzyme - Lauble_2002_Biochemistry_41_12043 |
| Author(s) : Lauble H , Miehlich B , Forster S , Wajant H , Effenberger F |
| Ref : Biochemistry , 41 :12043 , 2002 |
| Abstract : Lauble_2002_Biochemistry_41_12043 |
| ESTHER : Lauble_2002_Biochemistry_41_12043 |
| PubMedSearch : Lauble_2002_Biochemistry_41_12043 |
| PubMedID: 12356304 |
| Gene_locus related to this paper: sorbi-hnl |
| Title : The sng2 mutant of Arabidopsis is defective in the gene encoding the serine carboxypeptidase-like protein sinapoylglucose:choline sinapoyltransferase - Shirley_2001_Plant.J_28_83 |
| Author(s) : Shirley AM , McMichael CM , Chapple C |
| Ref : Plant J , 28 :83 , 2001 |
| Abstract : Shirley_2001_Plant.J_28_83 |
| ESTHER : Shirley_2001_Plant.J_28_83 |
| PubMedSearch : Shirley_2001_Plant.J_28_83 |
| PubMedID: 11696189 |
| Gene_locus related to this paper: arath-SCP19 |
| Title : An acyltransferase catalyzing the formation of diacylglucose is a serine carboxypeptidase-like protein - Li_2000_Proc.Natl.Acad.Sci.U.S.A_97_6902 |
| Author(s) : Li AX , Steffens JC |
| Ref : Proc Natl Acad Sci U S A , 97 :6902 , 2000 |
| Abstract : Li_2000_Proc.Natl.Acad.Sci.U.S.A_97_6902 |
| ESTHER : Li_2000_Proc.Natl.Acad.Sci.U.S.A_97_6902 |
| PubMedSearch : Li_2000_Proc.Natl.Acad.Sci.U.S.A_97_6902 |
| PubMedID: 10829071 |
| Gene_locus related to this paper: solbe-PLDP15 , solpn-q9lky6 |
| Title : Peptide aldehyde complexes with wheat serine carboxypeptidase II: implications for the catalytic mechanism and substrate specificity - Bullock_1996_J.Mol.Biol_255_714 |
| Author(s) : Bullock TL , Breddam K , Remington SJ |
| Ref : Journal of Molecular Biology , 255 :714 , 1996 |
| Abstract : Bullock_1996_J.Mol.Biol_255_714 |
| ESTHER : Bullock_1996_J.Mol.Biol_255_714 |
| PubMedSearch : Bullock_1996_J.Mol.Biol_255_714 |
| PubMedID: 8636973 |
| Gene_locus related to this paper: wheat-cbp02 |
| Title : Crystallization of a soluble form of the Kex1p serine carboxypeptidase from Saccharomyces cerevisiae - Shilton_1996_Protein.Sci_5_395 |
| Author(s) : Shilton BH , Li Y , Tessier D , Thomas DY , Cygler M |
| Ref : Protein Science , 5 :395 , 1996 |
| Abstract : Shilton_1996_Protein.Sci_5_395 |
| ESTHER : Shilton_1996_Protein.Sci_5_395 |
| PubMedSearch : Shilton_1996_Protein.Sci_5_395 |
| PubMedID: 8745419 |
| Gene_locus related to this paper: yeast-kex01 |
| Title : Site-Directed Mutagenesis on (Serine) Carboxypeptidase Y from Yeast. The Significance of Thr60 and Met398 in Hydrolysis and Aminolysis Reactions - Sorensen_1995_J.Am.Chem.Soc_117_5944 |
| Author(s) : Sorensen SB , Raaschou-Nielsen M , Mortensen UH , Remington SJ , Breddam K |
| Ref : Journal of the American Chemical Society , 117 :5944 , 1995 |
| Abstract : Sorensen_1995_J.Am.Chem.Soc_117_5944 |
| ESTHER : Sorensen_1995_J.Am.Chem.Soc_117_5944 |
| PubMedSearch : Sorensen_1995_J.Am.Chem.Soc_117_5944 |
| PubMedID: |
| Gene_locus related to this paper: yeast-cbpy1 |
| Title : Three-dimensional structure of the human 'protective protein': structure of the precursor form suggests a complex activation mechanism - Rudenko_1995_Structure_3_1249 |
| Author(s) : Rudenko G , Bonten E , d'Azzo A , Hol WG |
| Ref : Structure , 3 :1249 , 1995 |
| Abstract : Rudenko_1995_Structure_3_1249 |
| ESTHER : Rudenko_1995_Structure_3_1249 |
| PubMedSearch : Rudenko_1995_Structure_3_1249 |
| PubMedID: 8591035 |
| Gene_locus related to this paper: human-CTSA |
| Title : 2.8-A structure of yeast serine carboxypeptidase - Endrizzi_1994_Biochemistry_33_11106 |
| Author(s) : Endrizzi JA , Breddam K , Remington SJ |
| Ref : Biochemistry , 33 :11106 , 1994 |
| Abstract : Endrizzi_1994_Biochemistry_33_11106 |
| ESTHER : Endrizzi_1994_Biochemistry_33_11106 |
| PubMedSearch : Endrizzi_1994_Biochemistry_33_11106 |
| PubMedID: 7727362 |
| Gene_locus related to this paper: yeast-cbpy1 |
| Title : Molecular cloning of hydroxynitrile lyase from Sorghum bicolor (L.). Homologies to serine carboxypeptidases - Wajant_1994_Plant.Mol.Biol_26_735 |
| Author(s) : Wajant H , Mundry KW , Pfizenmaier K |
| Ref : Plant Mol Biol , 26 :735 , 1994 |
| Abstract : Wajant_1994_Plant.Mol.Biol_26_735 |
| ESTHER : Wajant_1994_Plant.Mol.Biol_26_735 |
| PubMedSearch : Wajant_1994_Plant.Mol.Biol_26_735 |
| PubMedID: 7948927 |
| Gene_locus related to this paper: sorbi-hnl |
| Title : Structure of the complex of L-benzylsuccinate with wheat serine carboxypeptidase II at 2.0-A resolution - Bullock_1994_Biochemistry_33_11127 |
| Author(s) : Bullock TL , Branchaud B , Remington SJ |
| Ref : Biochemistry , 33 :11127 , 1994 |
| Abstract : Bullock_1994_Biochemistry_33_11127 |
| ESTHER : Bullock_1994_Biochemistry_33_11127 |
| PubMedSearch : Bullock_1994_Biochemistry_33_11127 |
| PubMedID: 7727364 |
| Gene_locus related to this paper: wheat-cbp02 |
| Title : Refined atomic model of wheat serine carboxypeptidase II at 2.2-A resolution - Liao_1992_Biochemistry_31_9796 |
| Author(s) : Liao DI , Breddam K , Sweet RM , Bullock T , Remington SJ |
| Ref : Biochemistry , 31 :9796 , 1992 |
| Abstract : Liao_1992_Biochemistry_31_9796 |
| ESTHER : Liao_1992_Biochemistry_31_9796 |
| PubMedSearch : Liao_1992_Biochemistry_31_9796 |
| PubMedID: 1390755 |
| Gene_locus related to this paper: wheat-cbp02 |