POM-ERJ
Permeable lipophilic ester prodrug. Pivaloyloxymethyl prodrug of ERJ (ERJ is a DXR (1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitor). Parasite-internalized APEH plays an important role in the activation of substrates with branching at the alpha carbon, in keeping with its exopeptidase activity
General
Type : Pro-Drug, Drug, Propionate
Chemical_Nomenclature : [[(E)-3-[acetyl(hydroxy)amino]prop-1-enyl]-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate
Canonical SMILES : CC(=O)N(C\/C=C\/P(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)O
InChI : InChI=1S\/C17H30NO9P\/c1-13(19)18(22)9-8-10-28(23,26-11-24-14(20)16(2,3)4)27-12-25-15(21)17(5,6)7\/h8,10,22H,9,11-12H2,1-7H3\/b10-8+
InChIKey : LPMHROIKNZUFCZ-CSKARUKUSA-N
Other name(s) : pivaloyloxymethyl prodrug of ERJ || CHEMBL3103258 || SCHEMBL20621323 || RCB-185
MW : 423.4
Formula : C17H30NO9P
CAS_number :
PubChem : 73212867
UniChem : LPMHROIKNZUFCZ-CSKARUKUSA-N
Target
Structures : No structure
Families : ACPH_Peptidase_S9
References (1)
| Title : Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH) - Sundararaman_2024_bioRxiv__ |
| Author(s) : Sundararaman SA , Miller JJ , Daley EC , O'Brien KA , Kasak P , Daniels AM , Edwards RL , Heidel KM , Bague DA , Wilson MA , Koelper AJ , Kourtoglou EC , White AD , August SA , Apple GA , Rouamba RW , Durand AJ , Esteb JJ , Muller FL , Johnson RJ , Hoops GC , Dowd CS , Odom John AR |
| Ref : Biorxiv , : , 2024 |
| Abstract : |
| PubMedSearch : Sundararaman_2024_bioRxiv__ |
| PubMedID: 39257815 |
| Gene_locus related to this paper: human-APEH |