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ACPH_Peptidase_S9

Relationship

Family: ACPH_Peptidase_S9

Block: X

Parent Family: Peptidase_S9

Comment

Merops Subfamily S9C. Acylamino-acid-releasing enzyme ACPH APEH. This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. ACPH_Peptidase_S9: VPA-glucuronidase is responsible for maintaining the serum concentration of VPA, by cleaving its major metabolic product, valproic acid-beta-(d)-glucuronide (VPA-G),2 releasing VPA allowing its reabsorption. This enzyme is inhibited by carbapenems. Other names: oxidized protein hydrolase (OPH), acylamino-acid-releasing enzyme, N-formylmethionyl-peptidase, acylpeptide-hydrolase (APEH)acylaminoacyl peptidase (AAP)

Database

Interpro : IPR001375 Peptidase_S9 , IPR011042 6-blade_b-propeller_TolB-like

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00326 Peptidase_S9

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
1VE6 Crystal structure of an acylpeptide hydrolase\/esterase from Aeropyrum pernix K1 aerpe-APE1547
1VE7 Crystal structure of an acylpeptide hydrolase\/esterase from Aeropyrum pernix K1 in complex with p-nitrophenyl phosphate aerpe-APE1547
8WT1 Crystal structure of S9 carboxypeptidase from Geobacillus Sterothermophilus geose-a0a3l7d5q2
7QUN CryoEM structure of mammalian AAP in complex with Meropenem pig-acph
7PX8 CryoEM structure of mammalian (Sus scrofa pig) acylaminoacyl-peptidase pig-acph
7EP9 The structure of carboxypeptidase from Fusobacterium nucleatum fusnu-a0a1s1mbe1
5YZN Crystal structure of S9 peptidase (active form) from Deinococcus radiodurans R1 deira-DR0165
5YZM Crystal structure of S9 peptidase (inactive form) from Deinococcus radiodurans R1 deira-DR0165
5YZO Crystal structure of S9 peptidase mutant (S514A) from Deinococcus radiodurans R1 deira-DR0165
6IKG Crystal structure of substrate-bound S9 peptidase (S514A mutant) from Deinococcus radiodurans deira-DR0165
6IGP Crystal structure of S9 peptidase (inactive state) from Deinococcus radiodurans R1 in P212121 deira-DR0165
6IGQ Crystal structure of inactive state of S9 peptidase from Deinococcus radiodurans R1 (PMSF treated) deira-DR0165
6IGR Crystal structure of S9 peptidase (S514A mutant in inactive state) from Deinococcus radiodurans R1 deira-DR0165
5TXE AtxE2 Isopeptidase - S527A Variant with Astexin3-dC4 Bound astec-e8rup5
5TXC AtxE2 Isopeptidase - APO, a lasso peptide isopeptidase from Asticcacaulis excentricus astec-e8rup5
5JRL Crystal structure of the Sphingopyxin I Lasso Peptide Isopeptidase SpI-IsoP (Native) sphal-q1gq33
5JRK Crystal structure of the Sphingopyxin I Lasso Peptide Isopeptidase SpI-IsoP(SeMet-derived) sphal-q1gq33
4HXG Pyrococcus horikoshii acylaminoacyl peptidase (orthorhombic crystal form) pyrho-PH0594
4RE5 Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor 1 aerpe-APE1547
4RE6 Acylaminoacyl peptidase complexed with a chloromethylketone inhibitor 2 aerpe-APE1547
4HXF Acylaminoacyl peptidase in complex with Z-Gly-Gly-Phe-chloromethyl ketone pyrho-PH0594
4HXE Pyrococcus horikoshii acylaminoacyl peptidase (uncomplexed) pyrho-PH0594
3O4G Structure and Catalysis of Acylaminoacyl Peptidase: Closed and Open Subunits of a Dimer Oligopeptidase (1) aerpe-APE1547
3O4H Structure and Catalysis of Acylaminoacyl Peptidase: Closed and Open Subunits of a Dimer Oligopeptidase (2) aerpe-APE1547
3O4I Structure and Catalysis of Acylaminoacyl Peptidase: Closed and Open Subunits of a Dimer Oligopeptidase (3) aerpe-APE1547
3O4J Structure and Catalysis of Acylaminoacyl Peptidase: Closed and Open Subunits of a Dimer Oligopeptidase (4) aerpe-APE1547
2QZP Crystal structure of mutation of an acylptide hydrolase\/esterase from Aeropyrum pernix K1 aerpe-APE1547
2QR5 Aeropyrum pernix acylaminoacyl peptidase, H367A mutant aerpe-APE1547
2HU8 Acylaminoacyl peptidase S445A ApAAP Abz-Gly-Phe-OH complex aerpe-APE1547
2HU5 Acylaminoacyl peptidase ApAAP Gly-Phe-OH complex aerpe-APE1547
2HU7 Acylaminoacyl peptidase (ApAAP) Ac-Phe-OH complex aerpe-APE1547

Gene_locus Name Species
geose-a0a3l7d5q2 Geobacillus stearothermophilus (Bacillus stearothermophilus) S9 family peptidase Geobacillus stearothermophilus
fusnu-a0a1s1mbe1 Fusobacterium nucleatum S9 family peptidase Fusobacterium nucleatum
astec-e8rup5 Asticcacaulis excentricus (strain ATCC 15261 \/ DSM 4724 \/ VKM B-1370 \/ CB 48) Putative peptidase Asticcacaulis excentricus
sphal-q1gq33 Sphingopyxis alaskensis (strain DSM 13593 \/ LMG 18877 \/ RB2256) (Sphingomonas alaskensis) SpI-IsoP, Sala_2532, Dipeptidyl aminopeptidases\/acylaminoacyl-peptidases-like protein Sphingopyxis alaskensis RB2256
9baci-q2b4h3 Bacillus sp. NRRL B-14911 hypothetical protein Bacillus sp. NRRL B-14911
9baci-q2b998 Bacillus sp. NRRL B-14911 yuxl Bacillus sp. NRRL B-14911
9deio-q4h703 Deinococcus geothermalis DSM 11300 prolyl oligopeptidase active site region Deinococcus geothermalis DSM 11300
9eury-b7r0h7 Thermococcus sp. AM4 X-Pro dipeptidyl-peptidase (S15 family) Thermococcus sp. AM4
9eury-b7r3h6 Thermococcus sp. AM4 Acylamino acid-releasing enzyme Thermococcus sp. AM4
9eury-c1vb62 Halogeometricum borinquense DSM 11551 Dipeptidyl aminopeptidase\/acylaminoacyl peptidase Halogeometricum borinquense DSM 11551
9flao-q1vuy0 Psychroflexus torquis (strain ATCC 700755 \/ ACAM 623) acylaminoacyl-peptidase Psychroflexus torquis ATCC 700755
9gamm-q3nza8 Shewanella denitrificans OS217 peptidase s9, prolyl oligopeptidase active site region precursor Shewanella denitrificans OS217
9gamm-q3p4r9 Shewanella denitrificans OS217 peptidase s9, prolyl oligopeptidase active site region precursor Shewanella denitrificans OS217
9gamm-q3ql94 Shewanella amazonensis SB2B peptidase s9, prolyl oligopeptidase active site region precursor Shewanella amazonensis SB2B
9micc-q4nah7 Arthrobacter sp. FB24 prolyl oligopeptidase active site region Arthrobacter sp. FB24
9sphn-q3vd53 Sphingopyxis alaskensis RB2256 peptidase s9, prolyl oligopeptidase active site region precursor Sphingopyxis alaskensis RB2256
acib4-b5iaf1 Aciduliprofundum boonei (strain DSM 19572 \/ T469) Peptidase, S9A\/B\/C family, catalytic domain protein Aciduliprofundum boonei
acib4-b5iex9 Aciduliprofundum boonei (strain DSM 19572 \/ T469) Peptidase, S9A\/B\/C family, catalytic domain protein Aciduliprofundum boonei
acib4-b5ifi0 Aciduliprofundum boonei (strain DSM 19572 \/ T469) Acetyl xylan esterase family Aciduliprofundum boonei
aerpe-APE1547 Aeropyrum pernix 582aa long hypothetical acylamino-acid-releasing enzyme ApAAP Aeropyrum pernix
aerpe-APE1832 Aeropyrum pernix 659aa long hypothetical acylamino-acid-releasing enzyme Aeropyrum pernix
aerpe-APE2290 Aeropyrum pernix 572aa long hypothetical acylamino-acid-releasing enzyme Aeropyrum pernix
ailme-d2heu6 Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein Ailuropoda melanoleuca
arath-AARE Arabidopsis thaliana (Mouse-ear cress) acylamino acid-releasing enzymeAARE At4g14570 Arabidopsis thaliana
bacce-BC0192 Bacillus cereus, Bacillus thuringiensis, Bacillus weihenstephanensis, Bacillus anthracis, Bacillus mycoides, acylamino-acid-releasing enzyme (EC 3.4.19.1) Bacillus cereus
bacfr-q64qs3 Bacteroides fragilis, Bacteroides sp., putative alanyl dipeptidyl peptidase Bacteroides fragilis
bacha-BH3306 Bacillus halodurans hypothetical protein bh3306 Bacillus halodurans
bacld-q65fc5 Bacillus licheniformis (strain DSM 13 \/ ATCC 14580) putative acylaminoacyl-peptidase yuxl Bacillus licheniformis
bacsk-q5weq8 Bacillus clausii (strain KSM-K16) acylamino-acid-releasing enzyme (EC 3.4.19.1) Bacillus clausii
bacsu-YTMA Bacillus subtilis putative peptidase Bacillus subtilis
bacsu-yuxl Bacillus subtilis probable peptidase yuxl (EC 3.4.21.-) Bacillus subtilis
bacth-BT1838 Bacteroides thetaiotaomicron, Bacteroides caccae, Bacteroides sp., putative alanyl dipeptidyl peptidase Bacteroides thetaiotaomicron
bovin-acph Bos taurus (Bovine) Acylaminoacyl-peptidase Bos taurus
caebr-A8XDQ3 Caenorhabditis briggsae hypothetical protein cbg11649 (fragment) Caenorhabditis briggsae
caeel-R11E3.8 Caenorhabditis elegans hypothetical protein Caenorhabditis elegans
canfa-e2r7e8 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Canis lupus familiaris
chick-q5zjb6 Gallus gallus (Chicken) hypothetical protein Gallus gallus
chlaa-a9wik0 Chloroflexus aurantiacus J-10-fl hydrolase:wd40-like beta propeller Chloroflexus aurantiacus J-10-fl
chlau-q3dvz4 Chloroflexus aurantiacus J-10-fl peptidase s9, prolyl oligopeptidase active site region Chloroflexus aurantiacus J-10-fl
colp3-q47uc7 Colwellia psychrerythraea (strain 34H \/ ATCC BAA-681) (Vibrio psychroerythus) hypothetical protein Colwellia psychrerythraea
colp3-q485t4 Colwellia psychrerythraea (strain 34H \/ ATCC BAA-681) (Vibrio psychroerythus)hypothetical protein Colwellia psychrerythraea
crypv-q5cq27 Cryptosporidium parvum Cryptosporidium hominis carboxy terminus similar to n-acylaminoacyl-peptide hydrolase Cryptosporidium parvum
cytjo-q1xps7 Flavobacterium johnsoniae UW101 peptidase s9, prolyl oligopeptidase active site region Flavobacterium johnsoniae UW101
cytjo-q1xsb4 Flavobacterium johnsoniae UW101 peptidase s9, prolyl oligopeptidase active site region precursor Flavobacterium johnsoniae UW101
cytjo-q1xxw1 Flavobacterium johnsoniae UW101 peptidase s9, prolyl oligopeptidase active site region Flavobacterium johnsoniae UW101
danre-q1rlp3 Danio rerio (Zebrafish) (Brachydanio rerio) zgc:136971 Danio rerio
danre-Q802D0 Danio rerio (Zebrafish) (Brachydanio rerio) similar to n-acylaminoacyl-peptide hydrolase (fragment) Danio rerio
deira-DR0165 Deinococcus radiodurans acyl-peptide hydrolase, putative Deinococcus radiodurans
dicdi-q54d66 Dictyostelium discoideum (Slime mold) hypothetical protein Dictyostelium discoideum
emeni-q5aqq8 Aspergillus nidulans FGSC A4 hypothetical protein Aspergillus nidulans FGSC A4
eryhl-Q2N8C6 Erythrobacter litoralis (strain HTCC2594) acylaminoacyl-peptidase Erythrobacter litoralis HTCC2594
ferac-q41qs5 Ferroplasma acidarmanus Fer1 peptidase s9, prolyl oligopeptidase active site region Ferroplasma acidarmanus Fer1
flaj1-a5ffg3 Flavobacterium johnsoniae (Cytophaga johnsonae), peptidase s9, prolyl oligopeptidase active site region Flavobacterium johnsoniae UW101
fusnu-FN1128 Fusobacterium nucleatum, Fusobacterium sp., acylamino-acid-releasing enzyme (EC 3.4.19.1) Fusobacterium nucleatum
geoka-q5kvz7 Geobacillus kaustophilus, Geobacillus sp. dipeptidyl aminopeptidases\/acylaminoacyl-peptidase Geobacillus kaustophilus
geoka-q5l1d4 Geobacillus kaustophilus acylaminoacyl-peptidase (EC 3.4.19.1) Geobacillus kaustophilus
gibze-q4iac9 Gibberella zeae (Fusarium graminearum) Dipeptidyl-peptidase V Gibberella zeae
glovi-q7njx8 Gloeobacter violaceus gll1703 protein Gloeobacter violaceus
halsp-YUXL Halobacterium salinarum, Halobacterium sp., Haloterrigena turkmenica, acylaminoacyl-peptidase Halobacterium sp.
harsa-e2b4e6 Harpegnathos saltator (Jerdon's jumping ant) Acylamino-acid-releasing enzyme Harpegnathos saltator
human-APEH Homo sapiens (Human) acylamino acid-releasing enzyme APH APEH Homo sapiens
idilo-q5qun1 Idiomarina loihiensis acylaminoacyl-peptidase Idiomarina loihiensis
idilo-q5qzv2 Idiomarina loihiensis acylaminoacyl-peptidase Idiomarina loihiensis
idilo-q5r068 Idiomarina loihiensis acylaminoacyl-peptidase Idiomarina loihiensis
lacre-q1u7s8 Lactobacillus reuteri 100-23 peptidase s9, prolyl oligopeptidase active site region Lactobacillus reuteri 100-23
legpa-q5x4r4 Legionella pneumophila (strain Paris) (strain Lens) Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 )acylaminoacyl peptidase Legionella pneumophila
mets5-a4ydw5 Metallosphaera sedula (strain ATCC 51363 \/ DSM 5348) Peptidase S9, prolyl oligopeptidase active site domain protein Metallosphaera sedula
mouse-apeh Mus musculus (Mouse) hydrolase) (aph) (acylaminoacyl-peptidase) Mus musculus
oceih-OB1081 Oceanobacillus iheyensis acylaminoacyl-peptidase (EC 3.4.19.1) Oceanobacillus iheyensis
orysa-q7xem8 Oryza sativa (japonica cultivar-group) putative acylaminoacyl-peptidase like protein AARE1 Oryza sativa
orysj-q338c0 Oryza sativa subsp. japonica subsp. indica (Rice) putative acylaminoacyl-peptidase like protein Oryza sativa
picto-q6kyx8 Picrophilus torridus prolyl endopeptidase (EC 3.4.21.26) Picrophilus torridus
picto-q6l217 Picrophilus torridus hypothetical peptidase Picrophilus torridus
plaba-q4z5y0 Plasmodium berghei dnaj domain protein, putative (fragment) Plasmodium berghei
plafa-PFC0950C Plasmodium falciparum (isolate 3D7) PF3D7_0321500 putative acylaminoacyl-peptidase PF3D7_0321500 Plasmodium falciparum
playo-q7rl69 Plasmodium yoelii yoelii putative acylaminoacyl-peptidase Plasmodium yoelii yoelii
porgi-q7mu18 Porphyromonas gingivalis (Bacteroides gingivalis) conserved domain protein Porphyromonas gingivalis
psea6-q15uu9 Pseudoalteromonas atlantica (strain T6c \/ ATCC BAA-1087) Peptidase S9, prolyl oligopeptidase active site region Pseudoalteromonas atlantica T6c
pseht-q3icu1 Pseudoalteromonas haloplanktis (strain TAC 125) putative peptidase Pseudoalteromonas haloplanktis
pseht-q3ida0 Pseudoalteromonas haloplanktis (strain TAC 125) putative enzyme Pseudoalteromonas haloplanktis
pseht-q3idf4 Pseudoalteromonas haloplanktis (strain TAC 125) putative secreted hydrolase (EC 3.4.19.1) Pseudoalteromonas haloplanktis
pseht-q3ife2 Pseudoalteromonas haloplanktis (strain TAC 125) hypothetical protein Pseudoalteromonas haloplanktis
pyrab-PAB1300 Pyrococcus abyssi (aph) (acylaminoacyl-peptidase) PYRAB15980 PAB1300 Pyrococcus abyssi
pyrab-PYRAB14490 Pyrococcus abyssi peptidase Pyrococcus abyssi
pyrae-PAE1002 Pyrobaculum aerophilum acylamino-acid-releasing enzyme, conjectural Pyrobaculum aerophilum
pyrfu-PF0318 Pyrococcus furiosus hypothetical protein pf0318 Pyrococcus furiosus
pyrho-PH0594 Pyrococcus horikoshii hypothetical protein ph0594 Pyrococcus horikoshii
pyrho-PH0863 Pyrococcus horikoshii hypothetical protein ph0863 Pyrococcus horikoshii
pyrko-q5jdq6 Pyrococcus kodakaraensis (Thermococcus kodakaraensis) acylamino acid-releasing enzyme Pyrococcus kodakaraensis
pyrko-q5jhc8 Pyrococcus kodakaraensis (Thermococcus kodakaraensis) acylamino acid-releasing enzyme Pyrococcus kodakaraensis
ratno-acph Rattus norvegicus (Rat) Acyl-peptide hydrolase\; Acylamino-acid-releasing enzyme Rattus norvegicus
rhoba-q7uz96 Rhodopirellula baltica probable acylaminoacyl-peptidase (EC 3.4.19.1) Rhodopirellula baltica
sacd2-q21ib9 Saccharophagus degradans (strain 2-40 \/ ATCC 43961 \/ DSM 17024) dipeptidyl aminopeptidases\/acylaminoacyl-peptidases-like precursor Saccharophagus degradans
salrd-q2rz19 Salinibacter ruber (strain DSM 13855) probable acylaminoacyl-peptidase, putative Salinibacter ruber
salrd-q2rzy1 Salinibacter ruber, acylaminoacyl-peptidase Salinibacter ruber
sheam-a1s8c0 Shewanella amazonensis (strain ATCC BAA-1098 \/ SB2B) peptidase s9, prolyl oligopeptidase active site region precursor Shewanella amazonensis SB2B
shefn-q07za8 Shewanella frigidimarina (strain NCIMB 400) peptidase s9, prolyl oligopeptidase active site region precursor Shewanella frigidimarina NCIMB 400
shefr-q3nr85 Shewanella frigidimarina NCIMB 400 peptidase s9, prolyl oligopeptidase active site region precursor Shewanella frigidimarina NCIMB 400
shelp-a3q9i1 Shewanella loihica (strain ATCC BAA-1088 \/ PV-4) peptidase s9, prolyl oligopeptidase active site region precursor Shewanella sp. PV-4
shelp-a3qgm7 Shewanella loihica (strain ATCC BAA-1088 \/ PV-4) Peptidase S9, prolyl oligopeptidase active site domain protein Shewanella loihica
sheon-SO1539 Shewanella oneidensis, Shewanella sp., Shewanella putrefaciens, conserved hypothetical protein Shewanella oneidensis
shepc-a4y4y2 Shewanella sp., Shewanella putrefaciens , peptidase s9 precursor Shewanella baltica OS155
solue-q01nb0 Solibacter usitatus (strain Ellin6076) peptidase s9, prolyl oligopeptidase active site region precursor Solibacter usitatus Ellin6076
solue-q01vd8 Solibacter usitatus Ellin6076 peptidase s9, prolyl oligopeptidase active site region precursor Solibacter usitatus Ellin6076
solue-q02b08 Solibacter usitatus Ellin6076 peptidase s9, prolyl oligopeptidase active site region Solibacter usitatus Ellin6076
solus-q43z37 Solibacter usitatus Ellin6076 peptidase s9, prolyl oligopeptidase active site region precursor Solibacter usitatus Ellin6076
solus-q444s6 Solibacter usitatus Ellin6076 peptidase s9, prolyl oligopeptidase active site region precursor Solibacter usitatus Ellin6076
solus-q445x1 Solibacter usitatus Ellin6076 prolyl oligopeptidase active site region Solibacter usitatus Ellin6076
staau-SAV1793 Staphylococcus aureus YtmA S9C family unassigned peptidase, an hypothetical protein sav1793 FphG Staphylococcus aureus
staep-SE1460 Staphylococcus epidermidis conserved hypothetical protein SERP1354 FphG Staphylococcus epidermidis
sulac-q4j6y4 Sulfolobus acidocaldarius dipeptidyl aminopeptidases\/acylaminoacyl-peptidase Sulfolobus acidocaldarius
sulac-q4j892 Sulfolobus acidocaldarius conserved prokaryal protein Sulfolobus acidocaldarius
sulir-f0nbu1 Sulfolobus islandicus (strain REY15A) DAP2, dipeptidyl aminopeptidase\/acylaminoacylpeptidase Sulfolobus islandicus
sulso-APEH1 Sulfolobus solfataricus, Sulfolobus islandicus, acylaminoacyl-peptidase, putative (apeh-1) (EC 3.4.19.1) Sulfolobus solfataricus
sulso-APEH2 Sulfolobus solfataricus (apeh-2) (EC 3.4.19.1) Sulfolobus solfataricus
sulso-APEH3 Sulfolobus solfataricus, Sulfolobus islandicus, acylaminoacyl-peptidase, putative (apeh-3) (EC 3.4.19.1) Sulfolobus solfataricus
sulto-ST0779 Sulfolobus tokodaii putative acylamino-acid-releasing enzyme Sulfolobus tokodaii
sulto-ST1737 Sulfolobus tokodaii putative acylamino-acid-releasing enzyme Sulfolobus tokodaii
sulto-ST1745 Sulfolobus tokodaii putative acylamino-acid-releasing enzyme Sulfolobus tokodaii
pig-acph Sus scrofa domestica (domestic pig) (EC 3.4.19.1) oxidized protein hydrolase (OPH), acylpeptide-hydrolase (APEH)acylaminoacyl peptidase (AAP) Sus scrofa
symth-q67qv2 Symbiobacterium thermophilum acylaminoacyl-peptidase Symbiobacterium thermophilum
symth-q67r02 Symbiobacterium thermophilum acylaminoacyl-peptidase Symbiobacterium thermophilum
synsc-q3alv8 Synechococcus sp. (strain CC9605) dipeptidyl aminopeptidases\/acylaminoacyl-peptidases-like Synechococcus sp.
tetng-q4rwa0 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetng-q4t173 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) hypothetical protein (fragment) Tetraodon nigroviridis
tetts-q23ck3 Tetrahymena thermophila SB210 prolyl oligopeptidase family protein Tetrahymena thermophila SB210
tetts-q239b4 Tetrahymena thermophila SB210 prolyl oligopeptidase family protein Tetrahymena thermophila SB210
tetts-q239b5 Tetrahymena thermophila SB210 prolyl oligopeptidase family protein Tetrahymena thermophila SB210
theac-TA0664 Thermoplasma acidophilum hypothetical protein ta0664 Thermoplasma acidophilum
thep3-b0kcf0 Thermoanaerobacter pseudethanolicus (Clostridium thermohydrosulfuricum), T. ethanolicus, T. brockii (T. finnii), T. mathranii, T. italicus, T. sp., esterase Thermoanaerobacter ethanolicus ATCC 33223
thet2-q72i91 Thermus thermophilus (strain HB27 \/ ATCC BAA-163 \/ DSM 7039) (strain HB8 \/ ATCC 27634 \/ DSM 579) acylamino-acid-releasing enzyme (EC 3.4.19.1) Thermus thermophilus
thete-DAP2 Thermoanaerobacter tengcongensis dipeptidyl aminopeptidases\/acylaminoacyl-peptidases Thermoanaerobacter tengcongensis
thetn-DAP2.2 Thermoanaerobacter tengcongensis, Carboxydibrachium pacificum, dipeptidyl aminopeptidases\/acylaminoacyl-peptidases Thermoanaerobacter tengcongensis
thevo-TV0908 Thermoplasma volcanium (strain ATCC 51530 \/ DSM 4299 \/ JCM 9571 \/ NBRC 15438 \/ GSS1)hypothetical protein tv0908 Thermoplasma volcanium
thevo-TVG0965471 Thermoplasma volcanium (strain ATCC 51530 \/ DSM 4299 \/ JCM 9571 \/ NBRC 15438 \/ GSS1) acylaminoacyl-peptidase Thermoplasma volcanium
trede-q73ri8 Treponema denticola hypothetical protein Treponema denticola
sphmi-a0a495rva9 Sphingosinicella microcystinivorans. Acylaminoacyl-peptidase Sphingosinicella microcystinivorans
sphsk-g2ijj5 Sphingobium sp. (strain NBRC 103272 \/ SYK-6). Putative S9 family peptidase Sphingobium sp.
9arch-v4zpv3 uncultured archaeon A07HR67. Dipeptidyl acylaminoacyl-peptidase uncultured archaeon A07HR67
9gamm-a0a2s7uwv4 Psychrosphaera saromensis. Peptidase S9 family protein Psychrosphaera saromensis

Gene_locus_frgt Name Species
9bact-a3i229 Algoriphagus sp. PR1 Acylaminoacyl-peptidase Algoriphagus sp. PR1
9gamm-a0y0z1 Alteromonadales bacterium TW-7 Putative enzyme Alteromonadales bacterium TW-7
leixx-q6afv3 Leifsonia xyli (subsp. xyli) acylaminoacyl-peptidase Leifsonia xyli
salrd-q2s0z0 Salinibacter ruber, dipeptidyl-peptidase Salinibacter ruber
salrd-q2s404 Salinibacter ruber (strain DSM 13855) acylaminoacyl-peptidase Salinibacter ruber
solue-q01uv9 Solibacter usitatus Ellin6076 prolyl oligopeptidase active site region Solibacter usitatus Ellin6076

Substrate Chemical Nomenclature Proteins
VPA-glucuronide (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(2-propylpentanoyloxy)oxane-2-carboxylic acid pig-acph
Astexin3-dC4 GPTPMVGLDSVSGQYWDQHA(PLAD) astec-e8rup5
Abz-Gly-Phe-OH N-(2-Aminobenzoyl)glycyl-L-phenylalaninamide aerpe-APE1547
Met-Ala-Ala (2S)-2-[[(2S)-2-[[(2S)-2-azaniumyl-4-methylsulfanylbutanoyl]amino]propanoyl]amino]propanoate deira-DR0165
Octylglucoside (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-octoxyoxane-3,4,5-triol aerpe-APE1547    canar-LipB    human-ABHD6    pseae-PA2949    canfa-1lipg
P-nitrophenyl-phosphate 4-nitrophenyl phosphate aerpe-APE1547
Paranitrophenyl-octanoate (4-nitrophenyl) octanoate 9firm-a0a0a0ymq9    9bact-Q0GMU2    psesp-OPH    human-NOTUM    pseae-PA2949    crysp-Q874E9    emeni-q5b2c1    fusso-cutas    thite-g2rae6    9flao-a0a330mq60    9flao-a0a0c1f4u8    malgo-a8puy1    9bact-6EB3    partm-GthFAE    9bact-a0a2h5z9r5    9actn-j7k890    9actn-j7kdc6    fusox-a0a1d3s5h0
Ac-Leu-p-nitroanilide (2S)-2-acetamido-4-methyl-N-(4-nitrophenyl)pentanamide

Inhibitor Chemical Nomenclature Proteins
DFP Diisopropylphosphorofluoridate arcfu-AF1763    human-DPP4    human-ACHE    human-BCHE    human-PLA2G7    bacce-BC3734    ecoli-IROE    fusso-cutas    human-FAP    human-CTSA    aspni-FAEA
Acetylleucine-chloromethyl-ketone N-[(3S)-1-chloro-5-methyl-2-oxohexan-3-yl]acetamide human-APEH
Meropenem 2S,3R,4S)-4-[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid pig-acph
AA74-1 [4-(4-hydroxy-2,6-dimethylheptan-4-yl)triazol-2-yl]-pyrrolidin-1-ylmethanone human-APEH
Gly-Phe-OH (2S)-2-[(2-aminoacetyl)amino]-3-phenylpropanoic acid aerpe-APE1547
Ac-Phe-OH (2S)-2-acetamido-3-phenylpropanoic acid aerpe-APE1547
Z-Gly-Gly-Phe-chloromethyl-ketone benzyl N-[2-[[2-[[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]carbamate aerpe-APE1547    pyrho-PH0594
PNPMPC
PNPPC (4-nitrophenyl) N-propylcarbamate
Ebelactone-A (3S,4S)-4-[(E,2S,6R,8S,9R,10R)-9-hydroxy-4,6,8,10-tetramethyl-7-oxododec-4-en-2-yl]-3-methyloxetan-2-one
ARI-3099 [(2R)-1-[(2R)-2-(pyridine-4-carbonylamino)propanoyl]pyrrolidin-2-yl]boronic acid human-FAP    human-APEH
ABP-C6 Hexyl 4-nitrophenyl (3-azidopropyl)phosphonate mouse-hslip    mouse-MGLL    mouse-Abhd11    mouse-Ces1d    mouse-ES10    mouse-lypla2    drome-CG18815    mouse-lypla1    mouse-Ces1c    mouse-Ces1f    mouse-Ces1g    mouse-PPME1    mouse-apeh    mouse-abhd5    mouse-lypl1    mouse-Ces2c    mouse-Ces2a    mouse-Ces2e    mouse-aryla    mouse-BCHE    mouse-dpp2    mouse-dpp4    mouse-C87498
NBD-HE-HP N-[2-[hexyl-(4-nitrophenoxy)phosphoryl]oxyethyl]-6-[(4-nitro-2,1,3-benzoxadiazol-7-yl)amino]hexanamide mouse-hslip    mouse-Ces1d    mouse-MGLL    mouse-ES10    mouse-Abhd11    drome-CG2059    mouse-lypla2    drome-CG18815    mouse-lypla1    mouse-Ces1c    mouse-Ces1f    mouse-PPME1    mouse-apeh    mouse-abhd5    drome-CG1882    mouse-lypl1    burce-lipaa    rhidl-lipas    drome-EST23aes07    drome-este6    drome-CG5355    drome-aes05    drome-aes02    drome-CG8425
VX-Biotin human-CTSA    human-ACHE    human-BCHE
Chlorpyrifos-oxon diethyl (3,5,6-trichloropyridin-2-yl) phosphate human-APEH
Dichlorvos 2,2-dichloroethenyl dimethyl phosphate human-APEH
Naled (1,2-dibromo-2,2-dichloroethyl) dimethyl phosphate human-APEH
Profenofos O-(4-Bromo-2-chlorophenyl)-O-ethyl-S-propyl phosphorothioate human-APEH
Tribufos S,S,S-Tributyltrithiophosphate human-APEH
Trichlorfon~Metrifonate (2,2,2-Trichloro-1-hydroxyethyl)-phosphonic acid dimethyl ester human-APEH

References (8)

Title : A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase-meropenem complex - Kiss-Szeman_2022_Chem.Sci_13_14264
Author(s) : Kiss-Szeman AJ , Takacs L , Orgovan Z , Straner P , Jakli I , Schlosser G , Masiulis S , Harmat V , Menyhard DK , Perczel A
Ref : Chem Sci , 13 :14264 , 2022
Abstract :
PubMedSearch : Kiss-Szeman_2022_Chem.Sci_13_14264
PubMedID: 36545146
Gene_locus related to this paper: pig-acph

Title : Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates - Chekan_2016_J.Am.Chem.Soc_138_16452
Author(s) : Chekan JR , Koos JD , Zong C , Maksimov MO , Link AJ , Nair SK
Ref : Journal of the American Chemical Society , 138 :16452 , 2016
Abstract :
PubMedSearch : Chekan_2016_J.Am.Chem.Soc_138_16452
PubMedID: 27998080
Gene_locus related to this paper: astec-e8rup5

Title : Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase - Fage_2016_Angew.Chem.Int.Ed.Engl_55_12717
Author(s) : Fage CD , Hegemann JD , Nebel AJ , Steinbach RM , Zhu S , Linne U , Harms K , Bange G , Marahiel MA
Ref : Angew Chem Int Ed Engl , 55 :12717 , 2016
Abstract :
PubMedSearch : Fage_2016_Angew.Chem.Int.Ed.Engl_55_12717
PubMedID: 27611791
Gene_locus related to this paper: sphal-q1gq33

Title : Catalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionality - Menyhard_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_461
Author(s) : Menyhard DK , Orgovan Z , Szeltner Z , Szamosi I , Harmat V
Ref : Acta Crystallographica D Biol Crystallogr , 71 :461 , 2015
Abstract :
PubMedSearch : Menyhard_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_461
PubMedID: 25760596
Gene_locus related to this paper: aerpe-APE1547

Title : A self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii: substrate selection achieved through multimerization - Menyhard_2013_J.Biol.Chem_288_17884
Author(s) : Menyhard DK , Kiss-Szeman A , Tichy-Racs E , Hornung B , Radi K , Szeltner Z , Domokos K , Szamosi I , Naray-Szabo G , Polgar L , Harmat V
Ref : Journal of Biological Chemistry , 288 :17884 , 2013
Abstract :
PubMedSearch : Menyhard_2013_J.Biol.Chem_288_17884
PubMedID: 23632025
Gene_locus related to this paper: pyrho-PH0594

Title : Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with carbapenem antibiotics - Suzuki_2010_Drug.Metab.Dispos_38_1538
Author(s) : Suzuki E , Yamamura N , Ogura Y , Nakai D , Kubota K , Kobayashi N , Miura S , Okazaki O
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 38 :1538 , 2010
Abstract :
PubMedSearch : Suzuki_2010_Drug.Metab.Dispos_38_1538
PubMedID: 20551238

Title : Discrimination of esterase and peptidase activities of acylaminoacyl peptidase from hyperthermophilic Aeropyrum pernix K1 by a single mutation - Wang_2006_J.Biol.Chem_281_18618
Author(s) : Wang Q , Yang G , Liu Y , Feng Y
Ref : Journal of Biological Chemistry , 281 :18618 , 2006
Abstract :
PubMedSearch : Wang_2006_J.Biol.Chem_281_18618
PubMedID: 16670095
Gene_locus related to this paper: aerpe-APE1547

Title : Crystal Structure of an Acylpeptide Hydrolase\/Esterase from Aeropyrum pernix K1. - Bartlam_2004_Structure.(Camb)_12_1481
Author(s) : Bartlam M , Wang G , Yang H , Gao R , Zhao X , Xie G , Cao S , Feng Y , Rao Z
Ref : Structure(Camb) , 12 :1481 , 2004
Abstract :
PubMedSearch : Bartlam_2004_Structure.(Camb)_12_1481
PubMedID: 15296741
Gene_locus related to this paper: aerpe-APE1547