ACPH_Peptidase_S9

Relationship

Family: ACPH_Peptidase_S9

Block: X

Parent Family: Peptidase_S9

Comment

Merops Subfamily S9C. Acylamino-acid-releasing enzyme ACPH APEH. This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. ACPH_Peptidase_S9: VPA-glucuronidase is responsible for maintaining the serum concentration of VPA, by cleaving its major metabolic product, valproic acid-beta-(d)-glucuronide (VPA-G),2 releasing VPA allowing its reabsorption. This enzyme is inhibited by carbapenems. Other names: oxidized protein hydrolase (OPH), acylamino-acid-releasing enzyme, N-formylmethionyl-peptidase, acylpeptide-hydrolase (APEH)acylaminoacyl peptidase (AAP)

Database

Interpro : IPR001375 Peptidase_S9 , IPR011042 6-blade_b-propeller_TolB-like

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00326 Peptidase_S9

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (31)

Genes Proteins in ACPH_Peptidase_S9 family (140)

Fragments of genes in ACPH_Peptidase_S9 family (6)

Structures in ACPH_Peptidase_S9 family (31)

Substrates in ACPH_Peptidase_S9 family (8)

Inhibitors in ACPH_Peptidase_S9 family (20)

References (8)

Title : A carbapenem antibiotic inhibiting a mammalian serine protease: structure of the acylaminoacyl peptidase-meropenem complex - Kiss-Szeman_2022_Chem.Sci_13_14264
Author(s) : Kiss-Szeman AJ , Takacs L , Orgovan Z , Straner P , Jakli I , Schlosser G , Masiulis S , Harmat V , Menyhard DK , Perczel A
Ref : Chem Sci , 13 :14264 , 2022
PubMedID: 36545146
Gene_locus related to this paper: pig-acph

Title : Structure of the Lasso Peptide Isopeptidase Identifies a Topology for Processing Threaded Substrates - Chekan_2016_J.Am.Chem.Soc_138_16452
Author(s) : Chekan JR , Koos JD , Zong C , Maksimov MO , Link AJ , Nair SK
Ref : Journal of the American Chemical Society , 138 :16452 , 2016
PubMedID: 27998080
Gene_locus related to this paper: astec-e8rup5

Title : Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase - Fage_2016_Angew.Chem.Int.Ed.Engl_55_12717
Author(s) : Fage CD , Hegemann JD , Nebel AJ , Steinbach RM , Zhu S , Linne U , Harms K , Bange G , Marahiel MA
Ref : Angew Chem Int Ed Engl , 55 :12717 , 2016
PubMedID: 27611791
Gene_locus related to this paper: sphal-q1gq33

Title : Catalytically distinct states captured in a crystal lattice: the substrate-bound and scavenger states of acylaminoacyl peptidase and their implications for functionality - Menyhard_2015_Acta.Crystallogr.D.Biol.Crystallogr_71_461
Author(s) : Menyhard DK , Orgovan Z , Szeltner Z , Szamosi I , Harmat V
Ref : Acta Crystallographica D Biol Crystallogr , 71 :461 , 2015
PubMedID: 25760596
Gene_locus related to this paper: aerpe-APE1547

Title : A self-compartmentalizing hexamer serine protease from Pyrococcus horikoshii: substrate selection achieved through multimerization - Menyhard_2013_J.Biol.Chem_288_17884
Author(s) : Menyhard DK , Kiss-Szeman A , Tichy-Racs E , Hornung B , Radi K , Szeltner Z , Domokos K , Szamosi I , Naray-Szabo G , Polgar L , Harmat V
Ref : Journal of Biological Chemistry , 288 :17884 , 2013
PubMedID: 23632025
Gene_locus related to this paper: pyrho-PH0594

Title : Identification of valproic acid glucuronide hydrolase as a key enzyme for the interaction of valproic acid with carbapenem antibiotics - Suzuki_2010_Drug.Metab.Dispos_38_1538
Author(s) : Suzuki E , Yamamura N , Ogura Y , Nakai D , Kubota K , Kobayashi N , Miura S , Okazaki O
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 38 :1538 , 2010
PubMedID: 20551238

Title : Discrimination of esterase and peptidase activities of acylaminoacyl peptidase from hyperthermophilic Aeropyrum pernix K1 by a single mutation - Wang_2006_J.Biol.Chem_281_18618
Author(s) : Wang Q , Yang G , Liu Y , Feng Y
Ref : Journal of Biological Chemistry , 281 :18618 , 2006
PubMedID: 16670095
Gene_locus related to this paper: aerpe-APE1547

Title : Crystal Structure of an Acylpeptide Hydrolase\/Esterase from Aeropyrum pernix K1. - Bartlam_2004_Structure.(Camb)_12_1481
Author(s) : Bartlam M , Wang G , Yang H , Gao R , Zhao X , Xie G , Cao S , Feng Y , Rao Z
Ref : Structure(Camb) , 12 :1481 , 2004
PubMedID: 15296741
Gene_locus related to this paper: aerpe-APE1547