human-APEH

Homo sapiens (Human) acylamino acid-releasing enzyme APH APEH

Comment

Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide. Preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser Belongs to peptidase family s9C, Fujino et al Q9P0Y2: P13798 2aa dif with Q9BQ33 old human-acph. DFP (IC(50) 11-17 nM), chlorpyrifos oxon (IC(50) 21-71 nM), dichlorvos (IC(50) 230-560 nM), naled (IC(50) 370-870 nM) (Quistad et al. 2005)

Relationship

Family : ACPH_Peptidase_S9

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MERQVLLSEP EEAAALYRGL SRQPALSAAC LGPEVTTQYG GQYRTVHTEW TQRDLERMEN IRFCRQYLVF HDGDSVVFAG PAGNSVETRG ELLSRESPSG SMKAVLRKAG GTGPGEEKQF LEVWEKNRKL KSFNLSVLEK HGPVYEDDCF GCLSWSHSET HLLYVAERKR PKAESFFQTK ALDVSASDDE IARLKKPDQP IKGDQFVFYE DWGENMVSKS IPVLCVLDVE SGNISVLEGV PENVSPGQAF WAPGDAGVVF VGWWHEPFRL GIRFCTNRRS ALYYVDLIGG KCELLSDDSL AVSSPRLSPD QCRIVYLQYP SLIPHHQCSQ LCLYDWYTKV TSVVVDVVPR QLGENFSGIY CSLLPLGCWS ADSQRVVFDS AQRSRQDLFA VDTQVGTVTS LTAGGSGGSW KLLTIDQDLM VAQFSTPSLP PTLKVGFLPS AGKEQSVLWV SLEEAEPIPD IHWGIRVLQP PPEQENVQYA GLDFEAILLQ PGSPPDKTQV PMVVMPHGGP HSSFVTAWML FPAMLCKMGF AVLLVNYRGS TGFGQDSILS LPGNVGHQDV KDVQFAVEQV LQEEHFDASH VALMGGSHGG FISCHLIGQY PETYRACVAR NPVINIASML GSTDIPDWCV VEAGFPFSSD CLPDLSVWAE MLDKSPIRYI PQVKTPLLLM LGQEDRRVPF KQGMEYYRAL KTRNVPVRLL LYPKSTHALS EVEVESDSFM NAVLWLRTHL GS

References (9)

Title : The DNA sequence, annotation and analysis of human chromosome 3 - Muzny_2006_Nature_440_1194
Author(s) : Muzny DM , Scherer SE , Kaul R , Wang J , Yu J , Sudbrak R , Buhay CJ , Chen R , Cree A , Ding Y , Dugan-Rocha S , Gill R , Gunaratne P , Harris RA , Hawes AC , Hernandez J , Hodgson AV , Hume J , Jackson A , Khan ZM , Kovar-Smith C , Lewis LR , Lozado RJ , Metzker ML , Milosavljevic A , Miner GR , Morgan MB , Nazareth LV , Scott G , Sodergren E , Song XZ , Steffen D , Wei S , Wheeler DA , Wright MW , Worley KC , Yuan Y , Zhang Z , Adams CQ , Ansari-Lari MA , Ayele M , Brown MJ , Chen G , Chen Z , Clendenning J , Clerc-Blankenburg KP , Davis C , Delgado O , Dinh HH , Dong W , Draper H , Ernst S , Fu G , Gonzalez-Garay ML , Garcia DK , Gillett W , Gu J , Hao B , Haugen E , Havlak P , He X , Hennig S , Hu S , Huang W , Jackson LR , Jacob LS , Kelly SH , Kube M , Levy R , Li Z , Liu B , Liu J , Liu W , Lu J , Maheshwari M , Nguyen BV , Okwuonu GO , Palmeiri A , Pasternak S , Perez LM , Phelps KA , Plopper FJ , Qiang B , Raymond C , Rodriguez R , Saenphimmachak C , Santibanez J , Shen H , Shen Y , Subramanian S , Tabor PE , Verduzco D , Waldron L , Wang Q , Williams GA , Wong GK , Yao Z , Zhang J , Zhang X , Zhao G , Zhou J , Zhou Y , Nelson D , Lehrach H , Reinhardt R , Naylor SL , Yang H , Olson M , Weinstock G , Gibbs RA
Ref : Nature , 440 :1194 , 2006
PubMedID: 16641997
Gene_locus related to this paper: human-AADAC , human-AADACL2 , human-ABHD5 , human-ABHD6 , human-ABHD10 , human-ABHD14A , human-APEH , human-BCHE , human-CIB , human-LIPH , human-MGLL , human-NLGN1 , human-PLA1A

Title : Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants - Quistad_2005_Toxicol.Sci_86_291
Author(s) : Quistad GB , Klintenberg R , Casida JE
Ref : Toxicol Sci , 86 :291 , 2005
PubMedID: 15888665
Gene_locus related to this paper: human-APEH

Title : Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase - Fujino_2000_Biochim.Biophys.Acta_1478_102
Author(s) : Fujino T , Watanabe K , Beppu M , Kikugawa K , Yasuda H
Ref : Biochimica & Biophysica Acta , 1478 :102 , 2000
PubMedID: 10719179
Gene_locus related to this paper: human-APEH

Title : The nucleotide sequence of human acylamino acid-releasing enzyme - Mitta_1996_DNA.Res_3_31
Author(s) : Mitta M , Ohnogi H , Mizutani S , Sakiyama F , Kato I and
Ref : DNA Research , 3 :31 , 1996
PubMedID: 8724851
Gene_locus related to this paper: human-APEH

Title : Description of an acylpeptide hydrolase from lens - Sharma_1992_Exp.Eye.Res_54_1005
Author(s) : Sharma KK , Ortwerth BJ
Ref : Experimental Eye Research , 54 :1005 , 1992
PubMedID: 1521574
Gene_locus related to this paper: human-APEH

Title : Deficiency of acylpeptide hydrolase in small-cell lung carcinoma cell lines - Scaloni_1992_J.Lab.Clin.Med_120_546
Author(s) : Scaloni A , Jones W , Pospischil M , Sassa S , Schneewind O , Popowicz AM , Bossa F , Graziano SL , Manning JM
Ref : Journal of Laboratory & Clinical Medicine , 120 :546 , 1992
PubMedID: 1328432
Gene_locus related to this paper: human-APEH

Title : Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities - Jones_1991_Proc.Natl.Acad.Sci.U.S.A_88_2194
Author(s) : Jones WM , Scaloni A , Bossa F , Popowicz AM , Schneewind O , Manning JM
Ref : Proc Natl Acad Sci U S A , 88 :2194 , 1991
PubMedID: 2006156
Gene_locus related to this paper: human-APEH

Title : The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase - Erlandsson_1991_Oncogene_6_1293
Author(s) : Erlandsson R , Boldog F , Persson B , Zabarovsky ER , Allikmets RL , Sumegi J , Klein G , Jornvall H
Ref : Oncogene , 6 :1293 , 1991
PubMedID: 1861871
Gene_locus related to this paper: human-APEH

Title : The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer - Naylor_1989_Genomics_4_355
Author(s) : Naylor SL , Marshall A , Hensel C , Martinez PF , Holley B , Sakaguchi AY
Ref : Genomics , 4 :355 , 1989
PubMedID: 2565880
Gene_locus related to this paper: human-APEH