Homo sapiens (Human) acylamino acid-releasing enzyme APH APEH
Cleavage of an N-acetyl or N-formyl amino acid from the N-terminus of a polypeptide. Preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser Belongs to peptidase family s9C, Fujino et al Q9P0Y2: P13798 2aa dif with Q9BQ33 old human-acph. DFP (IC(50) 11-17 nM), chlorpyrifos oxon (IC(50) 21-71 nM), dichlorvos (IC(50) 230-560 nM), naled (IC(50) 370-870 nM) (Quistad et al. 2005)
Family : ACPH_Peptidase_S9
Block : X
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMERQVLLSEP EEAAALYRGL SRQPALSAAC LGPEVTTQYG GQYRTVHTEW TQRDLERMEN IRFCRQYLVF HDGDSVVFAG PAGNSVETRG ELLSRESPSG SMKAVLRKAG GTGPGEEKQF LEVWEKNRKL KSFNLSVLEK HGPVYEDDCF GCLSWSHSET HLLYVAERKR PKAESFFQTK ALDVSASDDE IARLKKPDQP IKGDQFVFYE DWGENMVSKS IPVLCVLDVE SGNISVLEGV PENVSPGQAF WAPGDAGVVF VGWWHEPFRL GIRFCTNRRS ALYYVDLIGG KCELLSDDSL AVSSPRLSPD QCRIVYLQYP SLIPHHQCSQ LCLYDWYTKV TSVVVDVVPR QLGENFSGIY CSLLPLGCWS ADSQRVVFDS AQRSRQDLFA VDTQVGTVTS LTAGGSGGSW KLLTIDQDLM VAQFSTPSLP PTLKVGFLPS AGKEQSVLWV SLEEAEPIPD IHWGIRVLQP PPEQENVQYA GLDFEAILLQ PGSPPDKTQV PMVVMPHGGP HSSFVTAWML FPAMLCKMGF AVLLVNYRGS TGFGQDSILS LPGNVGHQDV KDVQFAVEQV LQEEHFDASH VALMGGSHGG FISCHLIGQY PETYRACVAR NPVINIASML GSTDIPDWCV VEAGFPFSSD CLPDLSVWAE MLDKSPIRYI PQVKTPLLLM LGQEDRRVPF KQGMEYYRAL KTRNVPVRLL LYPKSTHALS EVEVESDSFM NAVLWLRTHL GS
| Title : Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH) - Sundararaman_2024_bioRxiv__ |
| Author(s) : Sundararaman SA , Miller JJ , Daley EC , O'Brien KA , Kasak P , Daniels AM , Edwards RL , Heidel KM , Bague DA , Wilson MA , Koelper AJ , Kourtoglou EC , White AD , August SA , Apple GA , Rouamba RW , Durand AJ , Esteb JJ , Muller FL , Johnson RJ , Hoops GC , Dowd CS , Odom John AR |
| Ref : Biorxiv , : , 2024 |
| Abstract : |
| PubMedSearch : Sundararaman_2024_bioRxiv__ |
| PubMedID: 39257815 |
| Gene_locus related to this paper: human-APEH |
| Title : Blood acylpeptide hydrolase activity is a sensitive marker for exposure to some organophosphate toxicants - Quistad_2005_Toxicol.Sci_86_291 |
| Author(s) : Quistad GB , Klintenberg R , Casida JE |
| Ref : Toxicol Sci , 86 :291 , 2005 |
| Abstract : |
| PubMedSearch : Quistad_2005_Toxicol.Sci_86_291 |
| PubMedID: 15888665 |
| Gene_locus related to this paper: human-APEH |
| Title : Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase - Fujino_2000_Biochim.Biophys.Acta_1478_102 |
| Author(s) : Fujino T , Watanabe K , Beppu M , Kikugawa K , Yasuda H |
| Ref : Biochimica & Biophysica Acta , 1478 :102 , 2000 |
| Abstract : |
| PubMedSearch : Fujino_2000_Biochim.Biophys.Acta_1478_102 |
| PubMedID: 10719179 |
| Gene_locus related to this paper: human-APEH |
| Title : The nucleotide sequence of human acylamino acid-releasing enzyme - Mitta_1996_DNA.Res_3_31 |
| Author(s) : Mitta M , Ohnogi H , Mizutani S , Sakiyama F , Kato I and |
| Ref : DNA Research , 3 :31 , 1996 |
| Abstract : |
| PubMedSearch : Mitta_1996_DNA.Res_3_31 |
| PubMedID: 8724851 |
| Gene_locus related to this paper: human-APEH |
| Title : Description of an acylpeptide hydrolase from lens - Sharma_1992_Exp.Eye.Res_54_1005 |
| Author(s) : Sharma KK , Ortwerth BJ |
| Ref : Experimental Eye Research , 54 :1005 , 1992 |
| Abstract : |
| PubMedSearch : Sharma_1992_Exp.Eye.Res_54_1005 |
| PubMedID: 1521574 |
| Gene_locus related to this paper: human-APEH |
| Title : Deficiency of acylpeptide hydrolase in small-cell lung carcinoma cell lines - Scaloni_1992_J.Lab.Clin.Med_120_546 |
| Author(s) : Scaloni A , Jones W , Pospischil M , Sassa S , Schneewind O , Popowicz AM , Bossa F , Graziano SL , Manning JM |
| Ref : Journal of Laboratory & Clinical Medicine , 120 :546 , 1992 |
| Abstract : |
| PubMedSearch : Scaloni_1992_J.Lab.Clin.Med_120_546 |
| PubMedID: 1328432 |
| Gene_locus related to this paper: human-APEH |
| Title : Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities - Jones_1991_Proc.Natl.Acad.Sci.U.S.A_88_2194 |
| Author(s) : Jones WM , Scaloni A , Bossa F , Popowicz AM , Schneewind O , Manning JM |
| Ref : Proc Natl Acad Sci U S A , 88 :2194 , 1991 |
| Abstract : |
| PubMedSearch : Jones_1991_Proc.Natl.Acad.Sci.U.S.A_88_2194 |
| PubMedID: 2006156 |
| Gene_locus related to this paper: human-APEH |
| Title : The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase - Erlandsson_1991_Oncogene_6_1293 |
| Author(s) : Erlandsson R , Boldog F , Persson B , Zabarovsky ER , Allikmets RL , Sumegi J , Klein G , Jornvall H |
| Ref : Oncogene , 6 :1293 , 1991 |
| Abstract : |
| PubMedSearch : Erlandsson_1991_Oncogene_6_1293 |
| PubMedID: 1861871 |
| Gene_locus related to this paper: human-APEH |
| Title : The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer - Naylor_1989_Genomics_4_355 |
| Author(s) : Naylor SL , Marshall A , Hensel C , Martinez PF , Holley B , Sakaguchi AY |
| Ref : Genomics , 4 :355 , 1989 |
| Abstract : |
| PubMedSearch : Naylor_1989_Genomics_4_355 |
| PubMedID: 2565880 |
| Gene_locus related to this paper: human-APEH |