Pimaricin-linear-analogue-synthetic
Synthetisc substrate used for hydrolysis and cyclization catalyzed by Pim TE. Chemical derivation of the full-length linear pimaricin polyketide chain 5d by N-acetylcysteamine (SNAC).
General
Type : SNAC, Polyketide, Macrolide
Chemical_Nomenclature :
Canonical SMILES : CC(NCCSC(C[C@@H](C=CC[C@@H](C[C@@]1(C[C@@H]([C@H]([C@H](C[C@H](C=CC=CC=CC=CC[C@@H](C)O)O)O1)C)O)O)O)O)=O)=O
InChI : InChI=1S\/C31H49NO9S\/c1-22(33)12-9-7-5-4-6-8-10-13-25(35)18-29-23(2)28(38)21-31(40,41-29)20-27(37)15-11-14-26(36)19-30(39)42-17-16-32-24(3)34\/h4-11,13-14,22-23,25-29,33,35-38,40H,12,15-21H2,1-3H3,(H,32,34)\/t22-,23-,25+,26-,27+,28+,29+,31-\/m1\/s1
InChIKey : PBXSPMAZTPAQBE-LDMKVQEYSA-N
Other name(s) : Compound 7
Target
Structures : No structure
Families : Thioesterase
References (1)
| Title : Structural and Mechanistic Insights into Chain Release of the Polyene PKS Thioesterase Domain - Zhou_2022_ACS.Catal_12_762 |
| Author(s) : Zhou Y , Tao W , Qi Z , Wei J , Shi T , Kang Q , Zheng J , Zhao Y , Bai L |
| Ref : ACS Catal , 12 :762 , 2022 |
| Abstract : |
| PubMedSearch : Zhou_2022_ACS.Catal_12_762 |
| PubMedID: |
| Gene_locus related to this paper: 9actn-f1cla7 |