Thioesterase

Relationship

Family: Thioesterase

Block: X

Parent Family: No family

Comment

"Thioesterase domains often occur integrated in or associated with peptide synthetases which are involved in the non-ribosomal synthesis of peptide antibiotics. Thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Only the last domain TE thioesterase of the acv synthetase (acvs) is included in ESTHER (Polyketide synthase Polyene PKS). Human fatty acid synthase (FAS) is uniquely expressed at high levels in many tumor types. Pharmacological inhibition of FAS therefore represents an important therapeutic opportunity. The drug Orlistat, which has been approved by the US Food and Drug Administration, inhibits FAS, induces tumor cell-specific apoptosis. Families TE-16 TE-17 TE-18 in ThYme database"

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

References (34)

Title : Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis - Little_2022_Nat.Prod.Rep_39_163
Author(s) : Little RF , Hertweck C
Ref : Nat Prod Rep , 39 :163 , 2022
Abstract : Little_2022_Nat.Prod.Rep_39_163
ESTHER : Little_2022_Nat.Prod.Rep_39_163
PubMedSearch : Little_2022_Nat.Prod.Rep_39_163
PubMedID: 34622896

Title : Structural and Mechanistic Insights into Chain Release of the Polyene PKS Thioesterase Domain - Zhou_2022_ACS.Catal_12_762
Author(s) : Zhou Y , Tao W , Qi Z , Wei J , Shi T , Kang Q , Zheng J , Zhao Y , Bai L
Ref : ACS Catal , 12 :762 , 2022
Abstract : Zhou_2022_ACS.Catal_12_762
ESTHER : Zhou_2022_ACS.Catal_12_762
PubMedSearch : Zhou_2022_ACS.Catal_12_762
PubMedID:
Gene_locus related to this paper: 9actn-f1cla7

Title : Thioesterase enzyme families: Functions, structures, and mechanisms - Caswell_2021_Protein.Sci__
Author(s) : Caswell BT , de Carvalho CC , Nguyen H , Roy M , Nguyen T , Cantu DC
Ref : Protein Science , : , 2021
Abstract : Caswell_2021_Protein.Sci__
ESTHER : Caswell_2021_Protein.Sci__
PubMedSearch : Caswell_2021_Protein.Sci__
PubMedID: 34921469

Title : Trapping biosynthetic acyl-enzyme intermediates with encoded 2,3-diaminopropionic acid - Huguenin-Dezot_2019_Nature_565_112
Author(s) : Huguenin-Dezot N , Alonzo DA , Heberlig GW , Mahesh M , Nguyen DP , Dornan MH , Boddy CN , Schmeing TM , Chin JW
Ref : Nature , 565 :112 , 2019
Abstract : Huguenin-Dezot_2019_Nature_565_112
ESTHER : Huguenin-Dezot_2019_Nature_565_112
PubMedSearch : Huguenin-Dezot_2019_Nature_565_112
PubMedID: 30542153
Gene_locus related to this paper: 9acto-q1psf3

Title : Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture - Miller_2016_J.Biol.Chem_291_22559
Author(s) : Miller BR , Drake EJ , Shi C , Aldrich CC , Gulick AM
Ref : Journal of Biological Chemistry , 291 :22559 , 2016
Abstract : Miller_2016_J.Biol.Chem_291_22559
ESTHER : Miller_2016_J.Biol.Chem_291_22559
PubMedSearch : Miller_2016_J.Biol.Chem_291_22559
PubMedID: 27597544
Gene_locus related to this paper: ecoli-entf

Title : Structures of two distinct conformations of holo-non-ribosomal peptide synthetases - Drake_2016_Nature_529_235
Author(s) : Drake EJ , Miller BR , Shi C , Tarrasch JT , Sundlov JA , Allen CL , Skiniotis G , Aldrich CC , Gulick AM
Ref : Nature , 529 :235 , 2016
Abstract : Drake_2016_Nature_529_235
ESTHER : Drake_2016_Nature_529_235
PubMedSearch : Drake_2016_Nature_529_235
PubMedID: 26762461
Gene_locus related to this paper: aciba-AB3403 , ecoli-entf

Title : Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate? - Horsman_2016_Nat.Prod.Rep_33_183
Author(s) : Horsman ME , Hari TP , Boddy CN
Ref : Nat Prod Rep , 33 :183 , 2016
Abstract : Horsman_2016_Nat.Prod.Rep_33_183
ESTHER : Horsman_2016_Nat.Prod.Rep_33_183
PubMedSearch : Horsman_2016_Nat.Prod.Rep_33_183
PubMedID: 25642666

Title : Crystal Structure and Substrate Specificity of Human Thioesterase 2: Insights into the Molecular Basis for the Modulation of Fatty Acid Synthase - Ritchie_2016_J.Biol.Chem_291_3520
Author(s) : Ritchie MK , Johnson LC , Clodfelter JE , Pemble CWt , Fulp BE , Furdui CM , Kridel SJ , Lowther WT
Ref : Journal of Biological Chemistry , 291 :3520 , 2016
Abstract : Ritchie_2016_J.Biol.Chem_291_3520
ESTHER : Ritchie_2016_J.Biol.Chem_291_3520
PubMedSearch : Ritchie_2016_J.Biol.Chem_291_3520
PubMedID: 26663084
Gene_locus related to this paper: human-OLAH

Title : Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis - Argyropoulos_2016_Biochim.Biophys.Acta_1860_486
Author(s) : Argyropoulos P , Bergeret F , Pardin C , Reimer JM , Pinto A , Boddy CN , Schmeing TM
Ref : Biochimica & Biophysica Acta , 1860 :486 , 2016
Abstract : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486
ESTHER : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486
PubMedSearch : Argyropoulos_2016_Biochim.Biophys.Acta_1860_486
PubMedID: 26592346
Gene_locus related to this paper: sacer-ery3

Title : Estimation of Hydrogen-Exchange Protection Factors from MD Simulation Based on Amide Hydrogen Bonding Analysis - Park_2015_J.Chem.Inf.Model_55_1914
Author(s) : Park IH , Venable JD , Steckler C , Cellitti SE , Lesley SA , Spraggon G , Brock A
Ref : J Chem Inf Model , 55 :1914 , 2015
Abstract : Park_2015_J.Chem.Inf.Model_55_1914
ESTHER : Park_2015_J.Chem.Inf.Model_55_1914
PubMedSearch : Park_2015_J.Chem.Inf.Model_55_1914
PubMedID: 26241692
Gene_locus related to this paper: human-FASN

Title : ThYme: a database for thioester-active enzymes - Cantu_2011_Nucleic.Acids.Res_39_D342
Author(s) : Cantu DC , Chen Y , Lemons ML , Reilly PJ
Ref : Nucleic Acids Research , 39 :D342 , 2011
Abstract : Cantu_2011_Nucleic.Acids.Res_39_D342
ESTHER : Cantu_2011_Nucleic.Acids.Res_39_D342
PubMedSearch : Cantu_2011_Nucleic.Acids.Res_39_D342
PubMedID: 21045059

Title : Structural basis for phosphopantetheinyl carrier domain interactions in the terminal module of nonribosomal peptide synthetases. - Liu_2011_Chem.Biol_18_1482
Author(s) : Liu Y , Zheng T , Bruner SD
Ref : Chemical Biology , 18 :1482 , 2011
Abstract : Liu_2011_Chem.Biol_18_1482
ESTHER : Liu_2011_Chem.Biol_18_1482
PubMedSearch : Liu_2011_Chem.Biol_18_1482
PubMedID: 22118682
Gene_locus related to this paper: ecoli-entf

Title : Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid - Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757
Author(s) : Zhang W , Chakravarty B , Zheng F , Gu Z , Wu H , Mao J , Wakil SJ , Quiocho FA
Ref : Proc Natl Acad Sci U S A , 108 :15757 , 2011
Abstract : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757
ESTHER : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757
PubMedSearch : Zhang_2011_Proc.Natl.Acad.Sci.U.S.A_108_15757
PubMedID: 21908709
Gene_locus related to this paper: human-FASN

Title : Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor - Whicher_2011_J.Biol.Chem_286_22558
Author(s) : Whicher JR , Florova G , Sydor PK , Singh R , Alhamadsheh M , Challis GL , Reynolds KA , Smith JL
Ref : Journal of Biological Chemistry , 286 :22558 , 2011
Abstract : Whicher_2011_J.Biol.Chem_286_22558
ESTHER : Whicher_2011_J.Biol.Chem_286_22558
PubMedSearch : Whicher_2011_J.Biol.Chem_286_22558
PubMedID: 21543318
Gene_locus related to this paper: strco-SC3F7.14

Title : Thioesterases: a new perspective based on their primary and tertiary structures. - Cantu_2010_Protein.Sci_19_1281
Author(s) : Cantu DC , Chen Y , Reilly PJ
Ref : Protein Science , 19 :1281 , 2010
Abstract : Cantu_2010_Protein.Sci_19_1281
ESTHER : Cantu_2010_Protein.Sci_19_1281
PubMedSearch : Cantu_2010_Protein.Sci_19_1281
PubMedID: 20506386

Title : Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis - Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246
Author(s) : Korman TP , Crawford JM , Labonte JW , Newman AG , Wong J , Townsend CA , Tsai SC
Ref : Proc Natl Acad Sci U S A , 107 :6246 , 2010
Abstract : Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246
ESTHER : Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246
PubMedSearch : Korman_2010_Proc.Natl.Acad.Sci.U.S.A_107_6246
PubMedID: 20332208
Gene_locus related to this paper: aspor-PKSL1

Title : Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase -
Author(s) : Scaglione JB , Akey DL , Sullivan R , Kittendorf JD , Rath CM , Kim ES , Smith JL , Sherman DH
Ref : Angew Chem Int Ed Engl , 49 :5726 , 2010
PubMedID: 20623733
Gene_locus related to this paper: 9acto-C6ZCS0

Title : Structure and functional analysis of RifR, the type II thioesterase from the rifamycin biosynthetic pathway - Claxton_2009_J.Biol.Chem_284_5021
Author(s) : Claxton HB , Akey DL , Silver MK , Admiraal SJ , Smith JL
Ref : Journal of Biological Chemistry , 284 :5021 , 2009
Abstract : Claxton_2009_J.Biol.Chem_284_5021
ESTHER : Claxton_2009_J.Biol.Chem_284_5021
PubMedSearch : Claxton_2009_J.Biol.Chem_284_5021
PubMedID: 19103602
Gene_locus related to this paper: amyme-RIFR

Title : Structural basis for the selectivity of the external thioesterase of the surfactin synthetase - Koglin_2008_Nature_454_907
Author(s) : Koglin A , Lohr F , Bernhard F , Rogov VV , Frueh DP , Strieter ER , Mofid MR , Guntert P , Wagner G , Walsh CT , Marahiel MA , Dotsch V
Ref : Nature , 454 :907 , 2008
Abstract : Koglin_2008_Nature_454_907
ESTHER : Koglin_2008_Nature_454_907
PubMedSearch : Koglin_2008_Nature_454_907
PubMedID: 18704089
Gene_locus related to this paper: bacsu-srf4

Title : Crystal structure of the termination module of a nonribosomal peptide synthetase - Tanovic_2008_Science_321_659
Author(s) : Tanovic A , Samel SA , Essen LO , Marahiel MA
Ref : Science , 321 :659 , 2008
Abstract : Tanovic_2008_Science_321_659
ESTHER : Tanovic_2008_Science_321_659
PubMedSearch : Tanovic_2008_Science_321_659
PubMedID: 18583577
Gene_locus related to this paper: bacsu-srfac

Title : Dynamic thiolation-thioesterase structure of a non-ribosomal peptide synthetase - Frueh_2008_Nature_454_903
Author(s) : Frueh DP , Arthanari H , Koglin A , Vosburg DA , Bennett AE , Walsh CT , Wagner G
Ref : Nature , 454 :903 , 2008
Abstract : Frueh_2008_Nature_454_903
ESTHER : Frueh_2008_Nature_454_903
PubMedSearch : Frueh_2008_Nature_454_903
PubMedID: 18704088
Gene_locus related to this paper: ecoli-entf

Title : The crystal structure of a mammalian fatty acid synthase - Maier_2008_Science_321_1315
Author(s) : Maier T , Leibundgut M , Ban N
Ref : Science , 321 :1315 , 2008
Abstract : Maier_2008_Science_321_1315
ESTHER : Maier_2008_Science_321_1315
PubMedSearch : Maier_2008_Science_321_1315
PubMedID: 18772430
Gene_locus related to this paper: pig-q58g70

Title : Deconstruction of iterative multidomain polyketide synthase function - Crawford_2008_Science_320_243
Author(s) : Crawford JM , Thomas PM , Scheerer JR , Vagstad AL , Kelleher NL , Townsend CA
Ref : Science , 320 :243 , 2008
Abstract : Crawford_2008_Science_320_243
ESTHER : Crawford_2008_Science_320_243
PubMedSearch : Crawford_2008_Science_320_243
PubMedID: 18403714
Gene_locus related to this paper: aspor-PKSL1 , asppa-q6ueg5

Title : Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat - Pemble_2007_Nat.Struct.Mol.Biol_14_704
Author(s) : Pemble CWt , Johnson LC , Kridel SJ , Lowther WT
Ref : Nat Struct Mol Biol , 14 :704 , 2007
Abstract : Pemble_2007_Nat.Struct.Mol.Biol_14_704
ESTHER : Pemble_2007_Nat.Struct.Mol.Biol_14_704
PubMedSearch : Pemble_2007_Nat.Struct.Mol.Biol_14_704
PubMedID: 17618296
Gene_locus related to this paper: human-FASN

Title : The thioesterase domain of the fengycin biosynthesis cluster: a structural base for the macrocyclization of a non-ribosomal lipopeptide - Samel_2006_J.Mol.Biol_359_876
Author(s) : Samel SA , Wagner B , Marahiel MA , Essen LO
Ref : Journal of Molecular Biology , 359 :876 , 2006
Abstract : Samel_2006_J.Mol.Biol_359_876
ESTHER : Samel_2006_J.Mol.Biol_359_876
PubMedSearch : Samel_2006_J.Mol.Biol_359_876
PubMedID: 16697411
Gene_locus related to this paper: bacsu-FENB

Title : Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels - Giraldes_2006_Nat.Chem.Biol_2_531
Author(s) : Giraldes JW , Akey DL , Kittendorf JD , Sherman DH , Smith JL , Fecik RA
Ref : Nat Chemical Biology , 2 :531 , 2006
Abstract : Giraldes_2006_Nat.Chem.Biol_2_531
ESTHER : Giraldes_2006_Nat.Chem.Biol_2_531
PubMedSearch : Giraldes_2006_Nat.Chem.Biol_2_531
PubMedID: 16969373
Gene_locus related to this paper: strve-PIKAIV

Title : Structural basis for macrolactonization by the pikromycin thioesterase - Akey_2006_Nat.Chem.Biol_2_537
Author(s) : Akey DL , Kittendorf JD , Giraldes JW , Fecik RA , Sherman DH , Smith JL
Ref : Nat Chemical Biology , 2 :537 , 2006
Abstract : Akey_2006_Nat.Chem.Biol_2_537
ESTHER : Akey_2006_Nat.Chem.Biol_2_537
PubMedSearch : Akey_2006_Nat.Chem.Biol_2_537
PubMedID: 16969372
Gene_locus related to this paper: strve-PIKAIV

Title : Human fatty acid synthase: structure and substrate selectivity of the thioesterase domain - Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567
Author(s) : Chakravarty B , Gu Z , Chirala SS , Wakil SJ , Quiocho FA
Ref : Proc Natl Acad Sci U S A , 101 :15567 , 2004
Abstract : Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567
ESTHER : Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567
PubMedSearch : Chakravarty_2004_Proc.Natl.Acad.Sci.U.S.A_101_15567
PubMedID: 15507492
Gene_locus related to this paper: human-FASN

Title : Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases - Tsai_2002_Biochemistry_41_12598
Author(s) : Tsai SC , Lu H , Cane DE , Khosla C , Stroud RM
Ref : Biochemistry , 41 :12598 , 2002
Abstract : Tsai_2002_Biochemistry_41_12598
ESTHER : Tsai_2002_Biochemistry_41_12598
PubMedSearch : Tsai_2002_Biochemistry_41_12598
PubMedID: 12379102
Gene_locus related to this paper: sacer-ery3 , strve-PIKAIV

Title : Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. - Bruner_2002_Structure_10_301
Author(s) : Bruner SD , Weber T , Kohli RM , Schwarzer D , Marahiel MA , Walsh CT , Stubbs MT
Ref : Structure , 10 :301 , 2002
Abstract : Bruner_2002_Structure_10_301
ESTHER : Bruner_2002_Structure_10_301
PubMedSearch : Bruner_2002_Structure_10_301
PubMedID: 12005429
Gene_locus related to this paper: bacsu-srfac

Title : Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel - Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808
Author(s) : Tsai SC , Miercke LJ , Krucinski J , Gokhale R , Chen JC , Foster PG , Cane DE , Khosla C , Stroud RM
Ref : Proc Natl Acad Sci U S A , 98 :14808 , 2001
Abstract : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808
ESTHER : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808
PubMedSearch : Tsai_2001_Proc.Natl.Acad.Sci.U.S.A_98_14808
PubMedID: 11752428
Gene_locus related to this paper: sacer-ery3

Title : Fatty acid synthesis: a potential selective target for antineoplastic therapy. -
Author(s) : Kuhajda FP , Jenner K , Wood FD , Hennigar RA , Jacobs LB , Dick JD , Pasternack GR
Ref : Proceedings of the National Academy of Sciences of the United States of America , 91 :6379 , 1994
PubMedID: 8022791
Gene_locus related to this paper: human-FASN

Title : -
Ref :
PubMedID:
Gene_locus related to this paper: aspte-curs2 , floch-rads2

Title : -
Ref :
PubMedID:
Gene_locus related to this paper: aspte-curs2 , floch-rads2

Structures (84)

Genes Proteins in Thioesterase family (629)

Fragments of genes in Thioesterase family (27)

Structures in Thioesterase family (84)

Substrates in Thioesterase family (9)

Inhibitors in Thioesterase family (29)