Isosorbide-2,5-diaspirinate

General

Type : Isosorbide, Salicylic, Acetate, Benzoate, Pro-Drug, Drug

Chemical_Nomenclature : [(3S,3aR,6R,6aR)-6-(2-acetyloxybenzoyl)oxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl] 2-acetyloxybenzoate

Canonical SMILES : CC(=O)OC1=CC=CC=C1C(=O)OC2COC3C2OCC3OC(=O)C4=CC=CC=C4OC(=O)C

InChI : InChI=1S\/C24H22O10\/c1-13(25)31-17-9-5-3-7-15(17)23(27)33-19-11-29-22-20(12-30-21(19)22)34-24(28)16-8-4-6-10-18(16)32-14(2)26\/h3-10,19-22H,11-12H2,1-2H3\/t19-,20+,21-,22-\/m1\/s1

InChIKey : HUDBTWVKIKXIGG-CIAFKFPVSA-N

Other name(s) : ISDA  ||  CHEMBL458299  ||  SCHEMBL12860815  ||  DTXSID601177840


MW : 470.4

Formula : C24H22O10

CAS_number : 208338-33-4

PubChem : 9890875

UniChem : HUDBTWVKIKXIGG-CIAFKFPVSA-N

Target

Structures : No structure

Families : BCHE

References (2)

Title : Discovery of a true aspirin prodrug - Moriarty_2008_J.Med.Chem_51_7991
Author(s) : Moriarty LM , Lally MN , Carolan CG , Jones M , Clancy JM , Gilmer JF
Ref : Journal of Medicinal Chemistry , 51 :7991 , 2008
Abstract :
PubMedSearch : Moriarty_2008_J.Med.Chem_51_7991
PubMedID: 19049433

Title : Single oral dose study of two isosorbide-based aspirin prodrugs in the dog - Gilmer_2003_J.Pharm.Pharmacol_55_1351
Author(s) : Gilmer JF , Murphy MA , Shannon JA , Breen CG , Ryder SA , Clancy JM
Ref : J Pharm Pharmacol , 55 :1351 , 2003
Abstract :
PubMedSearch : Gilmer_2003_J.Pharm.Pharmacol_55_1351
PubMedID: 14607016