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Substrate Report for: N-formylkynurenine

Kynurenine formamidase (EC:3.5.1.9) catalyses the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.


General
Type Kynurenine, Oxobutanoate
Chemical_Nomenclature (2S)-2-amino-4-(2-formamidophenyl)-4-oxobutanoic acid
Canonical SMILES C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)NC=O
InChI InChI=1S/C11H12N2O4/c12-8(11(16)17)5-10(15)7-3-1-2-4-9(7)13-6-14/h1-4,6,8H,5,12H2,(H,13,14)(H,16,17)/t8-/m0/s1
InChIKey BYHJHXPTQMMKCA-QMMMGPOBSA-N
Other name(s) (S)-2-Amino-4-(2-formamidophenyl)-4-oxobutanoic acid ; N'-formylkynurenine ; (2S)-2-amino-4-(2-formamidophenyl)-4-oxobutanoic acid ; N-Formyl-L-kynurenine
________________________________________________________________________________________________
MW|236.22
Formula|C11H12N2O4
CAS_number|3978-11-8
PubChem|439788
UniChem|BYHJHXPTQMMKCA-QMMMGPOBSA-N
IUPHAR|
Wikipedia|N'-formylkynurenine

Target
Families | N-formylkynurenine ligand of proteins in family: Kynurenine-formamidase
Protein | drome-CG9542, human-AFMID, mouse-KFA, yeast-YDR428C

References:
Search PubMed for references concerning: N-formylkynurenine
    Title: Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster.
    Han Q, Robinson H, Li J
    Ref: Biochemical Journal, 446:253, 2012 : PubMed