Kynurenine-formamidase

Relationship

Family: Kynurenine-formamidase

Block: H

Parent Family: No family

Comment

Kynurenine formamidase (EC:3.5.1.9) catalyses the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. It is required for elimination of toxic metabolites

Database

Interpro : IPR027519 Kynurenine formamidase, vertebrates\/fungi-type KFase_ver\/fungi-typ

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF07859 Abhydrolase_3

Prints : No Print

EC Number : 3.5.1.9

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (4)

Genes Proteins in Kynurenine-formamidase family (364)

Fragments of genes in Kynurenine-formamidase family (5)

Structures in Kynurenine-formamidase family (4)

Substrates in Kynurenine-formamidase family (1)

Inhibitors in Kynurenine-formamidase family (2)

References (4)

Title : Biochemical identification and crystal structure of kynurenine formamidase from Drosophila melanogaster. - Han_2012_Biochem.J_446_253
Author(s) : Han Q , Robinson H , Li J
Ref : Biochemical Journal , 446 :253 , 2012
PubMedID: 22690733
Gene_locus related to this paper: drome-CG9542

Title : Identification of formyl kynurenine formamidase and kynurenine aminotransferase from Saccharomyces cerevisiae using crystallographic, bioinformatic and biochemical evidence - Wogulis_2008_Biochemistry_47_1608
Author(s) : Wogulis M , Chew ER , Donohoue PD , Wilson DK
Ref : Biochemistry , 47 :1608 , 2008
PubMedID: 18205391
Gene_locus related to this paper: yeast-YDR428C

Title : Crystal structure of an alpha\/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution -
Author(s) : Arndt JW , Schwarzenbacher R , Page R , Abdubek P , Ambing E , Biorac T , Canaves JM , Chiu HJ , Dai X , Deacon AM , DiDonato M , Elsliger MA , Godzik A , Grittini C , Grzechnik SK , Hale J , Hampton E , Han GW , Haugen J , Hornsby M , Klock HE , Koesema E , Kreusch A , Kuhn P , Jaroszewski L , Lesley SA , Levin I , McMullan D , McPhillips TM , Miller MD , Morse A , Moy K , Nigoghossian E , Ouyang J , Peti WS , Quijano K , Reyes R , Sims E , Spraggon G , Stevens RC , van den Bedem H , Velasquez J , Vincent J , von Delft F , Wang X , West B , White A , Wolf G , Xu Q , Zagnitko O , Hodgson KO , Wooley J , Wilson IA
Ref : Proteins , 58 :755 , 2005
PubMedID: 15624212
Gene_locus related to this paper: yeast-YDR428C

Title : Biochemical and genetic characterization of kynurenine formamidase from Drosophila melanogaster - Moore_1978_Biochem.Genet_16_619
Author(s) : Moore GP , Sullivan DT
Ref : Biochemical Genetics , 16 :619 , 1978
PubMedID: 83140
Gene_locus related to this paper: drome-CG9542