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Substrate Report for: Quinapril

Quinapril is a prodrug and non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Quinapril is hydrolized by carboxylesterases, into its active form quinaprilat, which binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This abolishes the potent vasoconstrictive actions of angiotensin II and leads to vasodilatation. Quinapril also causes a decrease in angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis, and increases bradykinin levels.


General
Type Isoquinoline, Not A/B H target, Drug, Pro-Drug, Angiotensin-converting enzyme inhibitor
Chemical_Nomenclature (3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
Canonical SMILES CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2CC3=CC=CC=C3CC2C(=O)O
InChI InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1
InChIKey JSDRRTOADPPCHY-HSQYWUDLSA-N
Other name(s) Quinaprilum ; Quinaprilum [Latin] ; Quinazil ; CHEBI:8713 ; CHEMBL1592
________________________________________________________________________________________________
MW|438.51
Formula|C25H30N2O5
CAS_number|85441-61-8
PubChem|54892
UniChem|JSDRRTOADPPCHY-HSQYWUDLSA-N
IUPHAR|
Wikipedia|Quinapril

Target
Families | Quinapril ligand of proteins in family: Carb_B_Chordata

References:
Search PubMed for references concerning: Quinapril
    Title: Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril
    Tarkiainen EK, Tornio A, Holmberg MT, Launiainen T, Neuvonen PJ, Backman JT, Niemi M
    Ref: British Journal of Clinical Pharmacology, 80:1131, 2015 : PubMed