Oxylipin

Oxylipin is a family of bioactive lipid metabolites that are produced when polyunsaturated fatty acids (PUFAs) undergo at least one round of dioxygen-dependent oxidation, which is catalyzed by cyclooxygenase (COX), lipoxygenase (LOX) or cytochrome P450 (CYP) epoxygenase family enzymes Oxylipins play an important role in the modulation of the tumor microenvironment (TME) and facilitate tumor cell proliferation, migration and invasion. Substrates of epoxyde hydrolase (There are many families of epoxide hydrolases not all of them are alpha\/beta hydrolases in particular bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities in particular Leukotriene A4 hydrolase (in blood cells). These can act on same oxylipin substrates as the a\/b hydrolase epoxide hydroalses)