CHEMBL1684295
Compound 9b inhibits human and mouse PrCP at IC50 values of 12.4 nM
General
Type : Pyrrolidine,Imidazole,Pyridine,Oxadiazol,Piperidine,Benzimidazole
Chemical_Nomenclature : 1-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]-3-[4-(3-pyridin-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]propan-1-one
Canonical SMILES : C1CC(N(C1)C(=O)CCN2CCC(CC2)C3=NC(=NO3)C4=CC=CC=N4)C5=NC6=CC(=C(C=C6N5)Cl)Cl
InChI : InChI=1S\/C26H27Cl2N7O2\/c27-17-14-20-21(15-18(17)28)31-25(30-20)22-5-3-10-35(22)23(36)8-13-34-11-6-16(7-12-34)26-32-24(33-37-26)19-4-1-2-9-29-19\/h1-2,4,9,14-16,22H,3,5-8,10-13H2,(H,30,31)\/t22-\/m0\/s1
InChIKey : OJCDGMHBQVTOKH-QFIPXVFZSA-N
Other name(s) : Compound 80,BDBM50338027,CHEMBL1684295,Compound 9B,(S)-1-(2-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)pyrrolidin-1-yl)-3-(4-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)propan-1-one
MW : 540.4
Formula : C26H27Cl2N7O2
CAS_number :
PubChem : 51003600
UniChem : OJCDGMHBQVTOKH-QFIPXVFZSA-N
IUPHAR :
Wikipedia :
Target
Families : CHEMBL1684295 ligand of proteins in family: Prolylcarboxypeptidase
Stucture :
Protein : human-PRCP
References (2)
| Title : The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors - Graham_2012_Bioorg.Med.Chem.Lett_22_658 |
| Author(s) : Graham TH , Shen HC , Liu W , Xiong Y , Verras A , Bleasby K , Bhatt UR , Chabin RM , Chen D , Chen Q , Garcia-Calvo M , Geissler WM , He H , Lassman ME , Shen Z , Tong X , Tung EC , Xie D , Xu S , Colletti SL , Tata JR , Hale JJ , Pinto S , Shen DM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :658 , 2012 |
| Abstract : Graham_2012_Bioorg.Med.Chem.Lett_22_658 |
| ESTHER : Graham_2012_Bioorg.Med.Chem.Lett_22_658 |
| PubMedSearch : Graham_2012_Bioorg.Med.Chem.Lett_22_658 |
| PubMedID: 22079761 |
| Gene_locus related to this paper: human-PRCP |
| Title : Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors - Shen_2011_Bioorg.Med.Chem.Lett_21_1299 |
| Author(s) : Shen HC , Ding FX , Zhou C , Xiong Y , Verras A , Chabin RM , Xu S , Tong X , Xie D , Lassman ME , Bhatt UR , Garcia-Calvo MM , Geissler W , Shen Z , Chen D , SinhaRoy R , Hale JJ , Tata JR , Pinto S , Shen DM , Colletti SL |
| Ref : Bioorganic & Medicinal Chemistry Lett , 21 :1299 , 2011 |
| Abstract : Shen_2011_Bioorg.Med.Chem.Lett_21_1299 |
| ESTHER : Shen_2011_Bioorg.Med.Chem.Lett_21_1299 |
| PubMedSearch : Shen_2011_Bioorg.Med.Chem.Lett_21_1299 |
| PubMedID: 21315588 |
| Gene_locus related to this paper: human-PRCP |