| Title : Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors - Debenham_2013_Bioorg.Med.Chem.Lett_23_6228 |
| Author(s) : Debenham JS , Graham TH , Verras A , Zhang Y , Clements MJ , Kuethe JT , Madsen-Duggan C , Liu W , Bhatt UR , Chen D , Chen Q , Garcia-Calvo M , Geissler WM , He H , Li X , Lisnock J , Shen Z , Tong X , Tung EC , Wiltsie J , Xu S , Hale JJ , Pinto S , Shen DM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 23 :6228 , 2013 |
| Abstract : |
| PubMedSearch : Debenham_2013_Bioorg.Med.Chem.Lett_23_6228 |
| PubMedID: 24157366 |
| Title : The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors - Graham_2012_Bioorg.Med.Chem.Lett_22_658 |
| Author(s) : Graham TH , Shen HC , Liu W , Xiong Y , Verras A , Bleasby K , Bhatt UR , Chabin RM , Chen D , Chen Q , Garcia-Calvo M , Geissler WM , He H , Lassman ME , Shen Z , Tong X , Tung EC , Xie D , Xu S , Colletti SL , Tata JR , Hale JJ , Pinto S , Shen DM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :658 , 2012 |
| Abstract : |
| PubMedSearch : Graham_2012_Bioorg.Med.Chem.Lett_22_658 |
| PubMedID: 22079761 |
| Gene_locus related to this paper: human-PRCP |
| Title : Expression, purification and crystallization of human prolylcarboxypeptidase. - Abeywickrema_2010_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_66_702 |
| Author(s) : Abeywickrema PD , Patel SB , Byrne NJ , Diehl RE , Hall DL , Ford RE , Rickert KW , Reid JC , Shipman JM , Geissler WM , Pryor KD , SinhaRoy R , Soisson SM , Lumb KJ , Sharma S |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 66 :702 , 2010 |
| Abstract : |
| PubMedSearch : Abeywickrema_2010_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_66_702 |
| PubMedID: 20516604 |
| Gene_locus related to this paper: human-PRCP |
| Title : Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity - Zhou_2010_J.Med.Chem_53_7251 |
| Author(s) : Zhou C , Garcia-Calvo M , Pinto S , Lombardo M , Feng Z , Bender K , Pryor KD , Bhatt UR , Chabin RM , Geissler WM , Shen Z , Tong X , Zhang Z , Wong KK , Roy RS , Chapman KT , Yang L , Xiong Y |
| Ref : Journal of Medicinal Chemistry , 53 :7251 , 2010 |
| Abstract : |
| PubMedSearch : Zhou_2010_J.Med.Chem_53_7251 |
| PubMedID: 20857914 |
| Gene_locus related to this paper: human-PRCP |
| Title : Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase - Zhao_2010_Proteomics_10_2882 |
| Author(s) : Zhao X , Southwick K , Cardasis HL , Du Y , Lassman ME , Xie D , El-Sherbeini M , Geissler WM , Pryor KD , Verras A , Garcia-Calvo M , Shen DM , Yates NA , Pinto S , Hendrickon RC |
| Ref : Proteomics , 10 :2882 , 2010 |
| Abstract : |
| PubMedSearch : Zhao_2010_Proteomics_10_2882 |
| PubMedID: 20517885 |
| Gene_locus related to this paper: human-PRCP |