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human-PRCP

Homo sapiens (Human) Lysosomal Pro-X carboxypeptidase C prolylcarboxypeptidase , Angiotensinase C, Proline carboxypeptidase (EC3.4.16.2)

Comment

Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. PRCP was originally discovered as an angiotensinase and has since been implicated in vasodilatory, proinflammatory, and metabolic pathways. For example, angiotensin II, III and prekallikrein are all inactivated by PRCP, implicating a role for the enzyme in hypertension, tissue proliferation and smooth muscle growth. PRCP is also reported to inactivate -melanocyte-stimulating hormone, a neuropeptide that plays a role in regulating appetite || Belongs to peptidase family s28

Relationship

Family : Prolylcarboxypeptidase

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MGRRALLLLL LSFLAPWATI ALRPALRALG SLHLPTNPTS LPAVAKNYSV LYFQQKVDHF GFNTVKTFNQ RYLVADKYWK KNGGSILFYT GNEGDIIWFC NNTGFMWDVA EELKAMLVFA EHRYYGESLP FGDNSFKDSR HLNFLTSEQA LADFAELIKH LKRTIPGAEN QPVIAIGGSY GGMLAAWFRM KYPHMVVGAL AASAPIWQFE DLVPCGVFMK IVTTDFRKSG PHCSESIHRS WDAINRLSNT GSGLQWLTGA LHLCSPLTSQ DIQHLKDWIS ETWVNLAMVD YPYASNFLQP LPAWPIKVVC QYLKNPNVSD SLLLQNIFQA LNVYYNYSGQ VKCLNISETA TSSLGTLGWS YQACTEVVMP FCTNGVDDMF EPHSWNLKEL SDDCFQQWGV RPRPSWITTM YGGKNISSHT NIVFSNGELD PWSGGGVTKD ITDTLVAVTI SEGAHHLDLR TKNALDPMSV LLARSLEVRH MKNWIRDFYD SAGKQH

References (28)

Title : Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China - Wu_2020_J.Renin.Angiotensin.Aldosterone.Syst_21_1470320320981316
Author(s) : Wu Y , Pan X , Jin X
Ref : J Renin Angiotensin Aldosterone Syst , 21 :1470320320981316 , 2020
Abstract :
PubMedSearch : Wu_2020_J.Renin.Angiotensin.Aldosterone.Syst_21_1470320320981316
PubMedID: 33319614
Gene_locus related to this paper: human-PRCP

Title : Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population - Wu_2020_J.Renin.Angiotensin.Aldosterone.Syst_21_1470320320919586
Author(s) : Wu Y , Yang H , Xiao C
Ref : J Renin Angiotensin Aldosterone Syst , 21 :1470320320919586 , 2020
Abstract :
PubMedSearch : Wu_2020_J.Renin.Angiotensin.Aldosterone.Syst_21_1470320320919586
PubMedID: 32448049
Gene_locus related to this paper: human-PRCP

Title : Fast oxidation of alpha-melanocyte-stimulating hormone and derived peptides under laboratory conditions causes irreproducible results-Insights from studies of prolylcarboxypeptidase in human cell types -
Author(s) : Bayer M , Tsiskarishvili N , Stegemann A , Bohm M , Konig S
Ref : Pigment Cell Melanoma Res , 33 :378 , 2020
PubMedID: 31837203
Gene_locus related to this paper: human-PRCP

Title : Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme -
Author(s) : Kehoe K , Van Elzen R , Verkerk R , Sim Y , Van der Veken P , Lambeir AM , De Meester I
Ref : Biochimica & Biophysica Acta , 1864 :1481 , 2016
PubMedID: 27449720
Gene_locus related to this paper: human-PRCP

Title : Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke - Kehoe_2015_Neurochem.Res_40_81
Author(s) : Kehoe K , Brouns R , Verkerk R , Engelborghs S , De Deyn PP , Hendriks D , De Meester I
Ref : Neurochem Res , 40 :81 , 2015
Abstract :
PubMedSearch : Kehoe_2015_Neurochem.Res_40_81
PubMedID: 25370794
Gene_locus related to this paper: human-PRCP

Title : Prolylcarboxypeptidase independently activates plasma prekallikrein (fletcher factor) - Wang_2014_Curr.Mol.Med_14_1173
Author(s) : Wang J , Matafonov A , Madkhali H , Mahdi F , Watson D , Schmaier AH , Gailani D , Shariat-Madar Z
Ref : Curr Mol Med , 14 :1173 , 2014
Abstract :
PubMedSearch : Wang_2014_Curr.Mol.Med_14_1173
PubMedID: 25324000
Gene_locus related to this paper: human-PRCP

Title : Prolylcarboxypeptidase promotes angiogenesis and vascular repair - Adams_2013_Blood_122_1522
Author(s) : Adams GN , Stavrou EX , Fang C , Merkulova A , Alaiti MA , Nakajima K , Morooka T , Merkulov S , Larusch GA , Simon DI , Jain MK , Schmaier AH
Ref : Blood , 122 :1522 , 2013
Abstract :
PubMedSearch : Adams_2013_Blood_122_1522
PubMedID: 23744584
Gene_locus related to this paper: human-PRCP

Title : Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population - Wu_2013_J.Renin.Angiotensin.Aldosterone.Syst_14_263
Author(s) : Wu Y , Yang H , Yang B , Yang K , Xiao C
Ref : J Renin Angiotensin Aldosterone Syst , 14 :263 , 2013
Abstract :
PubMedSearch : Wu_2013_J.Renin.Angiotensin.Aldosterone.Syst_14_263
PubMedID: 22679278
Gene_locus related to this paper: human-PRCP

Title : The discovery of non-benzimidazole and brain-penetrant prolylcarboxypeptidase inhibitors - Graham_2012_Bioorg.Med.Chem.Lett_22_658
Author(s) : Graham TH , Shen HC , Liu W , Xiong Y , Verras A , Bleasby K , Bhatt UR , Chabin RM , Chen D , Chen Q , Garcia-Calvo M , Geissler WM , He H , Lassman ME , Shen Z , Tong X , Tung EC , Xie D , Xu S , Colletti SL , Tata JR , Hale JJ , Pinto S , Shen DM
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :658 , 2012
Abstract :
PubMedSearch : Graham_2012_Bioorg.Med.Chem.Lett_22_658
PubMedID: 22079761
Gene_locus related to this paper: human-PRCP

Title : Discovery of benzimidazole pyrrolidinyl amides as prolylcarboxypeptidase inhibitors - Shen_2011_Bioorg.Med.Chem.Lett_21_1299
Author(s) : Shen HC , Ding FX , Zhou C , Xiong Y , Verras A , Chabin RM , Xu S , Tong X , Xie D , Lassman ME , Bhatt UR , Garcia-Calvo MM , Geissler W , Shen Z , Chen D , SinhaRoy R , Hale JJ , Tata JR , Pinto S , Shen DM , Colletti SL
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :1299 , 2011
Abstract :
PubMedSearch : Shen_2011_Bioorg.Med.Chem.Lett_21_1299
PubMedID: 21315588
Gene_locus related to this paper: human-PRCP

Title : Prolylcarboxypeptidase regulates proliferation, autophagy, and resistance to 4-hydroxytamoxifen-induced cytotoxicity in estrogen receptor-positive breast cancer cells - Duan_2011_J.Biol.Chem_286_2864
Author(s) : Duan L , Motchoulski N , Danzer B , Davidovich I , Shariat-Madar Z , Levenson VV
Ref : Journal of Biological Chemistry , 286 :2864 , 2011
Abstract :
PubMedSearch : Duan_2011_J.Biol.Chem_286_2864
PubMedID: 21087932
Gene_locus related to this paper: human-PRCP

Title : Design and synthesis of prolylcarboxypeptidase (PrCP) inhibitors to validate PrCP as a potential target for obesity - Zhou_2010_J.Med.Chem_53_7251
Author(s) : Zhou C , Garcia-Calvo M , Pinto S , Lombardo M , Feng Z , Bender K , Pryor KD , Bhatt UR , Chabin RM , Geissler WM , Shen Z , Tong X , Zhang Z , Wong KK , Roy RS , Chapman KT , Yang L , Xiong Y
Ref : Journal of Medicinal Chemistry , 53 :7251 , 2010
Abstract :
PubMedSearch : Zhou_2010_J.Med.Chem_53_7251
PubMedID: 20857914
Gene_locus related to this paper: human-PRCP

Title : Peptidomic profiling of human cerebrospinal fluid identifies YPRPIHPA as a novel substrate for prolylcarboxypeptidase - Zhao_2010_Proteomics_10_2882
Author(s) : Zhao X , Southwick K , Cardasis HL , Du Y , Lassman ME , Xie D , El-Sherbeini M , Geissler WM , Pryor KD , Verras A , Garcia-Calvo M , Shen DM , Yates NA , Pinto S , Hendrickon RC
Ref : Proteomics , 10 :2882 , 2010
Abstract :
PubMedSearch : Zhao_2010_Proteomics_10_2882
PubMedID: 20517885
Gene_locus related to this paper: human-PRCP

Title : Structural definition and substrate specificity of the S28 protease family: the crystal structure of human prolylcarboxypeptidase - Soisson_2010_BMC.Struct.Biol_10_16
Author(s) : Soisson SM , Patel SB , Abeywickrema PD , Byrne NJ , Diehl RE , Hall DL , Ford RE , Reid JC , Rickert KW , Shipman JM , Sharma S , Lumb KJ
Ref : BMC Struct Biol , 10 :16 , 2010
Abstract :
PubMedSearch : Soisson_2010_BMC.Struct.Biol_10_16
PubMedID: 20540760
Gene_locus related to this paper: human-PRCP

Title : Expression, purification and crystallization of human prolylcarboxypeptidase. - Abeywickrema_2010_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_66_702
Author(s) : Abeywickrema PD , Patel SB , Byrne NJ , Diehl RE , Hall DL , Ford RE , Rickert KW , Reid JC , Shipman JM , Geissler WM , Pryor KD , SinhaRoy R , Soisson SM , Lumb KJ , Sharma S
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 66 :702 , 2010
Abstract :
PubMedSearch : Abeywickrema_2010_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_66_702
PubMedID: 20516604
Gene_locus related to this paper: human-PRCP

Title : E112D polymorphism in the prolylcarboxypeptidase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients - Zhang_2009_Chin.Med.J.(Engl)_122_2461
Author(s) : Zhang Y , Hong XM , Xing HX , Li JP , Huo Y , Xu XP
Ref : Chinese Medical Journal (Engl) , 122 :2461 , 2009
Abstract :
PubMedSearch : Zhang_2009_Chin.Med.J.(Engl)_122_2461
PubMedID: 20079160
Gene_locus related to this paper: human-PRCP

Title : Prolylcarboxypeptidase: a cardioprotective enzyme - Mallela_2009_Int.J.Biochem.Cell.Biol_41_477
Author(s) : Mallela J , Yang J , Shariat-Madar Z
Ref : International Journal of Biochemistryistry & Cell Biology , 41 :477 , 2009
Abstract :
PubMedSearch : Mallela_2009_Int.J.Biochem.Cell.Biol_41_477
PubMedID: 18396440
Gene_locus related to this paper: human-PRCP

Title : The functional importance of the N-terminal region of human prolylcarboxypeptidase - Mallela_2008_Biochem.Biophys.Res.Commun_374_635
Author(s) : Mallela J , Perkins R , Yang J , Pedigo S , Rimoldi JM , Shariat-Madar Z
Ref : Biochemical & Biophysical Research Communications , 374 :635 , 2008
Abstract :
PubMedSearch : Mallela_2008_Biochem.Biophys.Res.Commun_374_635
PubMedID: 18656443
Gene_locus related to this paper: human-PRCP

Title : Prolylcarboxypeptidase gene, chronic hypertension, and risk of preeclampsia - Wang_2006_Am.J.Obstet.Gynecol_195_162
Author(s) : Wang L , Feng Y , Zhang Y , Zhou H , Jiang S , Niu T , Wei LJ , Xu X , Wang X
Ref : Am J Obstet Gynecol , 195 :162 , 2006
Abstract :
PubMedSearch : Wang_2006_Am.J.Obstet.Gynecol_195_162
PubMedID: 16681991
Gene_locus related to this paper: human-PRCP

Title : Human chromosome 11 DNA sequence and analysis including novel gene identification - Taylor_2006_Nature_440_497
Author(s) : Taylor TD , Noguchi H , Totoki Y , Toyoda A , Kuroki Y , Dewar K , Lloyd C , Itoh T , Takeda T , Kim DW , She X , Barlow KF , Bloom T , Bruford E , Chang JL , Cuomo CA , Eichler E , Fitzgerald MG , Jaffe DB , LaButti K , Nicol R , Park HS , Seaman C , Sougnez C , Yang X , Zimmer AR , Zody MC , Birren BW , Nusbaum C , Fujiyama A , Hattori M , Rogers J , Lander ES , Sakaki Y
Ref : Nature , 440 :497 , 2006
Abstract :
PubMedSearch : Taylor_2006_Nature_440_497
PubMedID: 16554811
Gene_locus related to this paper: human-PRCP

Title : Overexpression of prolylcarboxypeptidase enhances plasma prekallikrein activation on Chinese hamster ovary cells - Shariat-Madar_2005_Am.J.Physiol.Heart.Circ.Physiol_289_H2697
Author(s) : Shariat-Madar Z , Rahimy E , Mahdi F , Schmaier AH
Ref : American Journal of Physiology Heart Circ Physiol , 289 :H2697 , 2005
Abstract :
PubMedSearch : Shariat-Madar_2005_Am.J.Physiol.Heart.Circ.Physiol_289_H2697
PubMedID: 16113074
Gene_locus related to this paper: human-PRCP

Title : Recombinant prolylcarboxypeptidase activates plasma prekallikrein - Shariat-Madar_2004_Blood_103_4554
Author(s) : Shariat-Madar Z , Mahdi F , Schmaier AH
Ref : Blood , 103 :4554 , 2004
Abstract :
PubMedSearch : Shariat-Madar_2004_Blood_103_4554
PubMedID: 14996700
Gene_locus related to this paper: human-PRCP

Title : Complete sequencing and characterization of 21,243 full-length human cDNAs - Ota_2004_Nat.Genet_36_40
Author(s) : Ota T , Suzuki Y , Nishikawa T , Otsuki T , Sugiyama T , Irie R , Wakamatsu A , Hayashi K , Sato H , Nagai K , Kimura K , Makita H , Sekine M , Obayashi M , Nishi T , Shibahara T , Tanaka T , Ishii S , Yamamoto J , Saito K , Kawai Y , Isono Y , Nakamura Y , Nagahari K , Murakami K , Yasuda T , Iwayanagi T , Wagatsuma M , Shiratori A , Sudo H , Hosoiri T , Kaku Y , Kodaira H , Kondo H , Sugawara M , Takahashi M , Kanda K , Yokoi T , Furuya T , Kikkawa E , Omura Y , Abe K , Kamihara K , Katsuta N , Sato K , Tanikawa M , Yamazaki M , Ninomiya K , Ishibashi T , Yamashita H , Murakawa K , Fujimori K , Tanai H , Kimata M , Watanabe M , Hiraoka S , Chiba Y , Ishida S , Ono Y , Takiguchi S , Watanabe S , Yosida M , Hotuta T , Kusano J , Kanehori K , Takahashi-Fujii A , Hara H , Tanase TO , Nomura Y , Togiya S , Komai F , Hara R , Takeuchi K , Arita M , Imose N , Musashino K , Yuuki H , Oshima A , Sasaki N , Aotsuka S , Yoshikawa Y , Matsunawa H , Ichihara T , Shiohata N , Sano S , Moriya S , Momiyama H , Satoh N , Takami S , Terashima Y , Suzuki O , Nakagawa S , Senoh A , Mizoguchi H , Goto Y , Shimizu F , Wakebe H , Hishigaki H , Watanabe T , Sugiyama A , Takemoto M , Kawakami B , Watanabe K , Kumagai A , Itakura S , Fukuzumi Y , Fujimori Y , Komiyama M , Tashiro H , Tanigami A , Fujiwara T , Ono T , Yamada K , Fujii Y , Ozaki K , Hirao M , Ohmori Y , Kawabata A , Hikiji T , Kobatake N , Inagaki H , Ikema Y , Okamoto S , Okitani R , Kawakami T , Noguchi S , Itoh T , Shigeta K , Senba T , Matsumura K , Nakajima Y , Mizuno T , Morinaga M , Sasaki M , Togashi T , Oyama M , Hata H , Komatsu T , Mizushima-Sugano J , Satoh T , Shirai Y , Takahashi Y , Nakagawa K , Okumura K , Nagase T , Nomura N , Kikuchi H , Masuho Y , Yamashita R , Nakai K , Yada T , Ohara O , Isogai T , Sugano S
Ref : Nat Genet , 36 :40 , 2004
Abstract :
PubMedSearch : Ota_2004_Nat.Genet_36_40
PubMedID: 14702039
Gene_locus related to this paper: human-ABHD1 , human-ABHD4 , human-ABHD12 , human-ABHD16A , human-ACOT1 , human-LDAH , human-ABHD18 , human-CES1 , human-CES4A , human-CES5A , human-CPVL , human-DAGLB , human-EPHX2 , human-KANSL3 , human-LIPA , human-LPL , human-MEST , human-NDRG1 , human-NLGN1 , human-NLGN4X , human-PRCP , human-PRSS16 , human-SERAC1 , human-TMEM53 , human-cb069

Title : Identification of prolylcarboxypeptidase as the cell matrix-associated prekallikrein activator - Moreira_2002_FEBS.Lett_523_167
Author(s) : Moreira CR , Schmaier AH , Mahdi F , da Motta G , Nader HB , Shariat-Madar Z
Ref : FEBS Letters , 523 :167 , 2002
Abstract :
PubMedSearch : Moreira_2002_FEBS.Lett_523_167
PubMedID: 12123826
Gene_locus related to this paper: human-PRCP

Title : Identification and characterization of prolylcarboxypeptidase as an endothelial cell prekallikrein activator - Shariat-Madar_2002_J.Biol.Chem_277_17962
Author(s) : Shariat-Madar Z , Mahdi F , Schmaier AH
Ref : Journal of Biological Chemistry , 277 :17962 , 2002
Abstract :
PubMedSearch : Shariat-Madar_2002_J.Biol.Chem_277_17962
PubMedID: 11830581
Gene_locus related to this paper: human-PRCP

Title : Sequencing and cloning of human prolylcarboxypeptidase (angiotensinase C). Similarity to both serine carboxypeptidase and prolylendopeptidase families - Tan_1993_J.Biol.Chem_268_16631
Author(s) : Tan F , Morris PW , Skidgel RA , Erdos EG
Ref : Journal of Biological Chemistry , 268 :16631 , 1993
Abstract :
PubMedSearch : Tan_1993_J.Biol.Chem_268_16631
PubMedID: 8344943
Gene_locus related to this paper: human-PRCP

Title : Purification and properties of prolylcarboxypeptidase (angiotensinase C) from human kidney - Odya_1978_J.Biol.Chem_253_5927
Author(s) : Odya CE , Marinkovic DV , Hammon KJ , Stewart TA and
Ref : Journal of Biological Chemistry , 253 :5927 , 1978
Abstract :
PubMedSearch : Odya_1978_J.Biol.Chem_253_5927
PubMedID: 28321
Gene_locus related to this paper: human-PRCP

Title : New enzymatic route for the inactivation of angiotensin -
Author(s) : Yang HY , Erdos EG , Chiang TS
Ref : Nature , 218 :1224 , 1968
PubMedID: 4297812
Gene_locus related to this paper: human-PRCP