IL8
General
Type : Carboxamide,Oxadiazol,Azetidin
Chemical_Nomenclature : ~{N}-[2-[4-(azetidin-1-ylcarbonyl)phenyl]ethyl]-3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazole-5-carboxamide
Canonical SMILES : COc1ccc(cc1OC)c2nc(on2)C(=O)NCCc3ccc(cc3)C(=O)N4CCC4
InChI : InChI=1S\/C23H24N4O5\/c1-30-18-9-8-17(14-19(18)31-2)20-25-22(32-26-20)21(28)24-11-10-15-4-6-16(7-5-15)23(29)27-12-3-13-27\/h4-9,14H,3,10-13H2,1-2H3,(H,24,28)
InChIKey : GCZJCDQGYPXFCY-UHFFFAOYSA-N
Other name(s) :
MW : 436.47
Formula : C23H24N4O5
CAS_number :
PubChem :
UniChem : GCZJCDQGYPXFCY-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : IL8 ligand of proteins in family: Thioesterase
Stucture : 8Q17 Identification and optimisation of novel inhibitors of the Polyketide synthetase 13 thioesterase domain with antitubercular activity
Protein : myctu-PKS13
References (1)
| Title : Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity - Green_2023_J.Med.Chem__ |
| Author(s) : Green SR , Wilson C , Eadsforth TC , Punekar AS , Tamaki FK , Wood G , Caldwell N , Forte B , Norcross NR , Kiczun M , Post JM , Lopez-Roman EM , Engelhart CA , Lukac I , Zuccotto F , Epemolu O , Boshoff HIM , Schnappinger D , Walpole C , Gilbert IH , Read KD , Wyatt PG , Baragana B |
| Ref : Journal of Medicinal Chemistry , : , 2023 |
| Abstract : Green_2023_J.Med.Chem__ |
| ESTHER : Green_2023_J.Med.Chem__ |
| PubMedSearch : Green_2023_J.Med.Chem__ |
| PubMedID: 37948640 |
| Gene_locus related to this paper: myctu-PKS13 |