myctu-PKS13

Mycobacterium tuberculosis, Mycobacterium bovis, polyketide synthase Thioesterase domain (PKS13 Rv3800c MT3907)

Comment

There are more than 1000 strains. Other Uniprot entries and list of strains can be found with the link: Other strains

Relationship

Family : Thioesterase

Block : X

Position in NCBI Life Tree : Mycobacterium tuberculosis

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Corynebacteriales N E > Mycobacteriaceae N E > Mycobacterium N E > Mycobacterium tuberculosis complex N E > Mycobacterium tuberculosis N E

Molecular evidence

No mutation

5V3W - Crystal Structure of the Apo form of Thioesterase domain of Mtb Pks13 5V3X - Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM1 5V3Y - Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM16 5V3Z - Crystal Structure of the D1607N mutant form of Thioesterase domain of Mtb Pks13 5V40 - Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM6 5V41 - Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM5 5V42 - Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM3 7M7V - Crystal Structure of Mtb Pks13 Thioesterase domain in complex with Compound 6 Optimization of TAM16 7VJT - Crystal Structure of Mtb Pks13-TE in complex with inhibitor coumestan derivative 8 8Q0T - Mycobacterium tuberculosis Polyketide synthetase 13 thioesterase domain in complex with IJJ Compound 50 with antitubercular activity 8Q0U - Mycobacterium tuberculosis Polyketide synthetase 13 thioesterase domain in complex with IKG Compound 33 with antitubercular activity 8Q17 - Identification and optimisation of novel inhibitors of the Polyketide synthetase 13 thioesterase domain with antitubercular activity 8TQG - Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor X20419 8TQV - Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor X20403 8TR4 - Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor X20404 8TRY - Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor X20348

No kinetic

No disease

No substrate

Sequence

Peptide

VPVFVFHPAG GSTVVYEPLL GRLPADTPMY GFERVEGSIE ERAQQYVPKL IEMQGDGPYV LVGWSLGGVL AYACAIGLRR LGKDVRFVGL IDAVRAGEEI PQTKEEIRKR WDRYAAFAEK TFNVTIPAIP YEQLEELDDE GQVRFVLDAV SQSGVQIPAG IIEHQRTSYL DNRAIDTAQI QPYDGHVTLY MADRYHDDAI MFEPRYAVRQ PDGGWGEYVS DLEVVPIGGE HIQAIDEPII AKVGEHMSRA LGQIEADRTS EVGKQ

References (24)

Title : Identification and Optimization of Novel Inhibitors of the Polyketide Synthase 13 Thioesterase Domain with Antitubercular Activity - Green_2023_J.Med.Chem__
Author(s) : Green SR , Wilson C , Eadsforth TC , Punekar AS , Tamaki FK , Wood G , Caldwell N , Forte B , Norcross NR , Kiczun M , Post JM , Lopez-Roman EM , Engelhart CA , Lukac I , Zuccotto F , Epemolu O , Boshoff HIM , Schnappinger D , Walpole C , Gilbert IH , Read KD , Wyatt PG , Baragana B
Ref : Journal of Medicinal Chemistry , : , 2023
Abstract :
PubMedSearch : Green_2023_J.Med.Chem__
PubMedID: 37948640
Gene_locus related to this paper: myctu-PKS13

Title : An integrated computational approach towards novel drugs discovery against polyketide synthase 13 thioesterase domain of Mycobacterium tuberculosis - Altharawi_2023_Sci.Rep_13_7014
Author(s) : Altharawi A , Alossaimi MA , Alanazi MM , Alqahatani SM , Tahir Ul Qamar M
Ref : Sci Rep , 13 :7014 , 2023
Abstract :
PubMedSearch : Altharawi_2023_Sci.Rep_13_7014
PubMedID: 37117557
Gene_locus related to this paper: myctu-PKS13

Title : Structure-Based Optimization of Coumestan Derivatives as Polyketide Synthase 13-Thioesterase(Pks13-TE) Inhibitors with Improved hERG Profiles for Mycobacterium tuberculosis Treatment - Zhang_2022_J.Med.Chem_65_13240
Author(s) : Zhang W , Lun S , Wang SS , Cai YP , Yang F , Tang J , Bishai WR , Yu LF
Ref : Journal of Medicinal Chemistry , 65 :13240 , 2022
Abstract :
PubMedSearch : Zhang_2022_J.Med.Chem_65_13240
PubMedID: 36174223
Gene_locus related to this paper: myctu-PKS13

Title : Optimization of TAM16, a Benzofuran That Inhibits the Thioesterase Activity of Pks13\; Evaluation toward a Preclinical Candidate for a Novel Antituberculosis Clinical Target - Wilson_2022_J.Med.Chem_65_409
Author(s) : Wilson C , Ray P , Zuccotto F , Hernandez J , Aggarwal A , Mackenzie C , Caldwell N , Taylor M , Huggett M , Mathieson M , Murugesan D , Smith A , Davis S , Cocco M , Parai MK , Acharya A , Tamaki F , Scullion P , Epemolu O , Riley J , Stojanovski L , Lopez-Roman EM , Torres-Gomez PA , Toledo AM , Guijarro-Lopez L , Camino I , Engelhart CA , Schnappinger D , Massoudi LM , Lenaerts A , Robertson GT , Walpole C , Matthews D , Floyd D , Sacchettini JC , Read KD , Encinas L , Bates RH , Green SR , Wyatt PG
Ref : Journal of Medicinal Chemistry , 65 :409 , 2022
Abstract :
PubMedSearch : Wilson_2022_J.Med.Chem_65_409
PubMedID: 34910486
Gene_locus related to this paper: myctu-PKS13

Title : Design and synthesis of mycobacterial pks13 inhibitors: Conformationally rigid tetracyclic molecules - Zhang_2021_Eur.J.Med.Chem_213_113202
Author(s) : Zhang W , Liu LL , Lun S , Wang SS , Xiao S , Gunosewoyo H , Yang F , Tang J , Bishai WR , Yu LF
Ref : Eur Journal of Medicinal Chemistry , 213 :113202 , 2021
Abstract :
PubMedSearch : Zhang_2021_Eur.J.Med.Chem_213_113202
PubMedID: 33516983
Gene_locus related to this paper: myctu-PKS13

Title : Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II - Zhang_2019_J.Med.Chem_62_3575
Author(s) : Zhang W , Lun S , Liu LL , Xiao S , Duan G , Gunosewoyo H , Yang F , Tang J , Bishai WR , Yu LF
Ref : Journal of Medicinal Chemistry , 62 :3575 , 2019
Abstract :
PubMedSearch : Zhang_2019_J.Med.Chem_62_3575
PubMedID: 30875203
Gene_locus related to this paper: myctu-PKS13

Title : Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis - Zhang_2018_J.Med.Chem_61_791
Author(s) : Zhang W , Lun S , Wang SH , Jiang XW , Yang F , Tang J , Manson AL , Earl AM , Gunosewoyo H , Bishai WR , Yu LF
Ref : Journal of Medicinal Chemistry , 61 :791 , 2018
Abstract :
PubMedSearch : Zhang_2018_J.Med.Chem_61_791
PubMedID: 29328655
Gene_locus related to this paper: myctu-PKS13

Title : Crystallization and structure analysis of the core motif of the Pks13 acyltransferase domain from Mycobacterium tuberculosis - Yu_2018_PeerJ_6_e4728
Author(s) : Yu M , Dou C , Gu Y , Cheng W
Ref : PeerJ , 6 :e4728 , 2018
Abstract :
PubMedSearch : Yu_2018_PeerJ_6_e4728
PubMedID: 29761048
Gene_locus related to this paper: myctu-PKS13

Title : Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases - Goins_2018_Biochemistry_57_2383
Author(s) : Goins CM , Sudasinghe TD , Liu X , Wang Y , O'Doherty GA , Ronning DR
Ref : Biochemistry , 57 :2383 , 2018
Abstract :
PubMedSearch : Goins_2018_Biochemistry_57_2383
PubMedID: 29601187
Gene_locus related to this paper: myctu-a85c , myctu-PKS13 , myctu-Rv3802c

Title : Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13 - Aggarwal_2017_Cell_170_249
Author(s) : Aggarwal A , Parai MK , Shetty N , Wallis D , Woolhiser L , Hastings C , Dutta NK , Galaviz S , Dhakal RC , Shrestha R , Wakabayashi S , Walpole C , Matthews D , Floyd D , Scullion P , Riley J , Epemolu O , Norval S , Snavely T , Robertson GT , Rubin EJ , Ioerger TR , Sirgel FA , van der Merwe R , van Helden PD , Keller P , Bottger EC , Karakousis PC , Lenaerts AJ , Sacchettini JC
Ref : Cell , 170 :249 , 2017
Abstract :
PubMedSearch : Aggarwal_2017_Cell_170_249
PubMedID: 28669536
Gene_locus related to this paper: myctu-PKS13

Title : The alpha\/beta Hydrolase Fold Proteins of Mycobacterium tuberculosis, With Reference to their Contribution to Virulence - Johnson_2017_Curr.Protein.Pept.Sci_18_190
Author(s) : Johnson G
Ref : Curr Protein Pept Sci , 18 :190 , 2016
Abstract :
PubMedSearch : Johnson_2017_Curr.Protein.Pept.Sci_18_190
PubMedID: 27480283
Gene_locus related to this paper: myctu-bpoC , myctu-metx , myctu-MT1628 , myctu-MT3441 , myctu-RV0421C , myctu-RV0519C , myctu-RV0774C , myctu-Rv1191 , myctu-Rv3084 , myctu-Rv3591c , myctu-yc88 , myctu-a85a , myctu-a85b , myctu-a85c , myctu-cut3 , myctu-cutas1 , myctu-cutas2 , myctu-d5yk66 , myctu-ephA , myctu-ephB , myctu-ephc , myctu-ephd , myctu-ephE , myctu-ephF , myctu-hpx , myctu-linb , myctu-lipG , myctu-lipJ , myctu-LIPS , myctu-lipv , myctu-LPQC , myctu-LPQP , myctu-MBTB , myctu-mpt51 , myctu-p71654 , myctu-p95011 , myctu-PKS6 , myctu-PKS13 , myctu-ppe42 , myctu-ppe63 , myctu-Rv1430 , myctu-RV0045C , myctu-Rv0077c , myctu-Rv0151c , myctu-Rv0152c , myctu-Rv0159c , myctu-Rv0160c , myctu-rv0183 , myctu-Rv0217c , myctu-Rv0220 , myctu-Rv0272c , myctu-RV0293C , myctu-RV0457C , myctu-RV0782 , myctu-RV0840C , myctu-Rv1069c , myctu-Rv1076 , myctu-RV1123C , myctu-Rv1184c , myctu-Rv1190 , myctu-RV1192 , myctu-RV1215C , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-RV1639C , myctu-RV1683 , myctu-RV1758 , myctu-Rv1800 , myctu-Rv1833c , myctu-Rv2045c , myctu-RV2054 , myctu-Rv2284 , myctu-RV2296 , myctu-Rv2385 , myctu-Rv2485c , myctu-RV2627C , myctu-RV2672 , myctu-RV2695 , myctu-RV2765 , myctu-RV2800 , myctu-RV2854 , myctu-Rv2970c , myctu-Rv3097c , myctu-rv3177 , myctu-Rv3312c , myctu-RV3452 , myctu-RV3473C , myctu-Rv3487c , myctu-Rv3569c , myctu-RV3724 , myctu-Rv3802c , myctu-Rv3822 , myctu-y0571 , myctu-y963 , myctu-Y1834 , myctu-y1835 , myctu-y2079 , myctu-Y2307 , myctu-ym23 , myctu-ym24 , myctu-YR15 , myctu-yt28

Title : Synthesis and evaluation of new 2-aminothiophenes against Mycobacterium tuberculosis - Thanna_2016_Org.Biomol.Chem_14_6119
Author(s) : Thanna S , Knudson SE , Grzegorzewicz A , Kapil S , Goins CM , Ronning DR , Jackson M , Slayden RA , Sucheck SJ
Ref : Org Biomol Chem , 14 :6119 , 2016
Abstract :
PubMedSearch : Thanna_2016_Org.Biomol.Chem_14_6119
PubMedID: 27251120
Gene_locus related to this paper: myctu-PKS13

Title : The polyketide synthase Pks13 catalyzes a novel mechanism of lipid transfer in mycobacteria - Gavalda_2014_Chem.Biol_21_1660
Author(s) : Gavalda S , Bardou F , Laval F , Bon C , Malaga W , Chalut C , Guilhot C , Mourey L , Daffe M , Quemard A
Ref : Chemical Biology , 21 :1660 , 2014
Abstract :
PubMedSearch : Gavalda_2014_Chem.Biol_21_1660
PubMedID: 25467124
Gene_locus related to this paper: myctu-PKS13

Title : Antituberculosis thiophenes define a requirement for Pks13 in mycolic acid biosynthesis - Wilson_2013_Nat.Chem.Biol_9_499
Author(s) : Wilson R , Kumar P , Parashar V , Vilcheze C , Veyron-Churlet R , Freundlich JS , Barnes SW , Walker JR , Szymonifka MJ , Marchiano E , Shenai S , Colangeli R , Jacobs WR, Jr. , Neiditch MB , Kremer L , Alland D
Ref : Nat Chemical Biology , 9 :499 , 2013
Abstract :
PubMedSearch : Wilson_2013_Nat.Chem.Biol_9_499
PubMedID: 23770708
Gene_locus related to this paper: myctu-PKS13

Title : Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase Pks13 - Bergeret_2012_J.Biol.Chem_287_33675
Author(s) : Bergeret F , Gavalda S , Chalut C , Malaga W , Quemard A , Pedelacq JD , Daffe M , Guilhot C , Mourey L , Bon C
Ref : Journal of Biological Chemistry , 287 :33675 , 2012
Abstract :
PubMedSearch : Bergeret_2012_J.Biol.Chem_287_33675
PubMedID: 22825853
Gene_locus related to this paper: myctu-PKS13

Title : Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry - Kelkar_2011_Mol.Cell.Proteomics_10_M111.011627
Author(s) : Kelkar DS , Kumar D , Kumar P , Balakrishnan L , Muthusamy B , Yadav AK , Shrivastava P , Marimuthu A , Anand S , Sundaram H , Kingsbury R , Harsha HC , Nair B , Prasad TS , Chauhan DS , Katoch K , Katoch VM , Chaerkady R , Ramachandran S , Dash D , Pandey A
Ref : Mol Cell Proteomics , 10 :M111 011627 , 2011
Abstract :
PubMedSearch : Kelkar_2011_Mol.Cell.Proteomics_10_M111.011627
PubMedID: 21969609
Gene_locus related to this paper: myctu-ephA , myctu-ephB , myctu-ephd , myctu-linb , myctu-MBTB , myctu-PKS13 , myctu-Rv1833c , myctu-RV2296 , myctu-RV2695 , myctu-RV2765

Title : Whole genome sequence analysis of Mycobacterium bovis bacillus Calmette-Guerin (BCG) Tokyo 172: a comparative study of BCG vaccine substrains - Seki_2009_Vaccine_27_1710
Author(s) : Seki M , Honda I , Fujita I , Yano I , Yamamoto S , Koyama A
Ref : Vaccine , 27 :1710 , 2009
Abstract :
PubMedSearch : Seki_2009_Vaccine_27_1710
PubMedID: 19200449
Gene_locus related to this paper: myctu-a85a , myctu-a85b , myctu-a85c , myctu-bpoC , myctu-cut3 , myctu-cutas1 , myctu-cutas2 , myctu-d5yk66 , myctu-ephB , myctu-ephc , myctu-ephd , myctu-ephE , myctu-hpx , myctu-linb , myctu-lipG , myctu-lipJ , myctu-LIPS , myctu-lipv , myctu-LPQC , myctu-LPQP , myctu-MBTB , myctu-metx , myctu-mpt51 , myctu-MT1628 , myctu-MT3441 , myctu-p71654 , myctu-p95011 , myctu-PKS6 , myctu-PKS13 , myctu-ppe42 , myctu-ppe63 , myctu-Rv1430 , myctu-RV0045C , myctu-Rv0077c , myctu-Rv0151c , myctu-Rv0152c , myctu-Rv0159c , myctu-Rv0160c , myctu-rv0183 , myctu-Rv0217c , myctu-Rv0220 , myctu-Rv0272c , myctu-RV0293C , myctu-RV0457C , myctu-RV0519C , myctu-RV0774C , myctu-RV0782 , myctu-RV0840C , myctu-Rv1069c , myctu-Rv1076 , myctu-RV1123C , myctu-Rv1184c , myctu-Rv1190 , myctu-Rv1191 , myctu-RV1192 , myctu-RV1215C , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-RV1639C , myctu-RV1683 , myctu-RV1758 , myctu-Rv1800 , myctu-Rv1833c , myctu-Rv2045c , myctu-RV2054 , myctu-RV2296 , myctu-Rv2385 , myctu-RV2627C , myctu-RV2672 , myctu-RV2695 , myctu-RV2765 , myctu-RV2800 , myctu-RV2854 , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-rv3177 , myctu-Rv3312c , myctu-RV3452 , myctu-RV3473C , myctu-Rv3487c , myctu-Rv3569c , myctu-Rv3591c , myctu-RV3724 , myctu-Rv3802c , myctu-Rv3822 , myctu-y0571 , myctu-y963 , myctu-Y1834 , myctu-y1835 , myctu-y2079 , myctu-yc88 , myctu-ym23 , myctu-ym24 , myctu-YR15 , myctu-yt28

Title : The Pks13\/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis - Gavalda_2009_J.Biol.Chem_284_19255
Author(s) : Gavalda S , Leger M , van der Rest B , Stella A , Bardou F , Montrozier H , Chalut C , Burlet-Schiltz O , Marrakchi H , Daffe M , Quemard A
Ref : Journal of Biological Chemistry , 284 :19255 , 2009
Abstract :
PubMedSearch : Gavalda_2009_J.Biol.Chem_284_19255
PubMedID: 19436070
Gene_locus related to this paper: myctu-PKS13

Title : The dual function of the Mycobacterium tuberculosis FadD32 required for mycolic acid biosynthesis - Leger_2009_Chem.Biol_16_510
Author(s) : Leger M , Gavalda S , Guillet V , van der Rest B , Slama N , Montrozier H , Mourey L , Quemard A , Daffe M , Marrakchi H
Ref : Chemical Biology , 16 :510 , 2009
Abstract :
PubMedSearch : Leger_2009_Chem.Biol_16_510
PubMedID: 19477415
Gene_locus related to this paper: myctu-PKS13

Title : Genome plasticity of BCG and impact on vaccine efficacy - Brosch_2007_Proc.Natl.Acad.Sci.U.S.A_104_5596
Author(s) : Brosch R , Gordon SV , Garnier T , Eiglmeier K , Frigui W , Valenti P , Dos Santos S , Duthoy S , Lacroix C , Garcia-Pelayo C , Inwald JK , Golby P , Garcia JN , Hewinson RG , Behr MA , Quail MA , Churcher C , Barrell BG , Parkhill J , Cole ST
Ref : Proc Natl Acad Sci U S A , 104 :5596 , 2007
Abstract :
PubMedSearch : Brosch_2007_Proc.Natl.Acad.Sci.U.S.A_104_5596
PubMedID: 17372194
Gene_locus related to this paper: myctu-a85a , myctu-a85b , myctu-a85c , myctu-bpoC , myctu-cut3 , myctu-cutas2 , myctu-d5yk66 , myctu-ephB , myctu-ephc , myctu-ephd , myctu-ephE , myctu-hpx , myctu-linb , myctu-lipG , myctu-lipJ , myctu-LIPS , myctu-lipv , myctu-LPQC , myctu-LPQP , myctu-MBTB , myctu-metx , myctu-mpt51 , myctu-MT1628 , myctu-p71654 , myctu-p95011 , myctu-PKS6 , myctu-PKS13 , myctu-ppe42 , myctu-ppe63 , myctu-Rv1430 , myctu-RV0045C , myctu-Rv0077c , myctu-Rv0151c , myctu-Rv0152c , myctu-Rv0159c , myctu-Rv0160c , myctu-rv0183 , myctu-Rv0217c , myctu-Rv0220 , myctu-Rv0272c , myctu-RV0293C , myctu-RV0457C , myctu-RV0519C , myctu-RV0774C , myctu-RV0782 , myctu-RV0840C , myctu-Rv1069c , myctu-Rv1076 , myctu-RV1123C , myctu-Rv1184c , myctu-Rv1191 , myctu-RV1192 , myctu-RV1215C , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-RV1639C , myctu-RV1683 , myctu-RV1758 , myctu-Rv1800 , myctu-Rv1833c , myctu-Rv2045c , myctu-RV2054 , myctu-Rv2284 , myctu-RV2296 , myctu-Rv2385 , myctu-Rv2485c , myctu-RV2627C , myctu-RV2672 , myctu-RV2695 , myctu-RV2765 , myctu-RV2800 , myctu-RV2854 , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-rv3177 , myctu-Rv3312c , myctu-RV3452 , myctu-RV3473C , myctu-Rv3487c , myctu-Rv3569c , myctu-Rv3591c , myctu-RV3724 , myctu-Rv3802c , myctu-Rv3822 , myctu-y0571 , myctu-y963 , myctu-Y1834 , myctu-y1835 , myctu-y2079 , myctu-yc88 , myctu-ym23 , myctu-ym24 , myctu-YR15 , myctu-yt28

Title : The nonredundant roles of two 4'-phosphopantetheinyl transferases in vital processes of Mycobacteria - Chalut_2006_Proc.Natl.Acad.Sci.U.S.A_103_8511
Author(s) : Chalut C , Botella L , de Sousa-D'Auria C , Houssin C , Guilhot C
Ref : Proc Natl Acad Sci U S A , 103 :8511 , 2006
Abstract :
PubMedSearch : Chalut_2006_Proc.Natl.Acad.Sci.U.S.A_103_8511
PubMedID: 16709676
Gene_locus related to this paper: myctu-PKS13

Title : The complete genome sequence of Mycobacterium bovis - Garnier_2003_Proc.Natl.Acad.Sci.U.S.A_100_7877
Author(s) : Garnier T , Eiglmeier K , Camus JC , Medina N , Mansoor H , Pryor M , Duthoy S , Grondin S , Lacroix C , Monsempe C , Simon S , Harris B , Atkin R , Doggett J , Mayes R , Keating L , Wheeler PR , Parkhill J , Barrell BG , Cole ST , Gordon SV , Hewinson RG
Ref : Proc Natl Acad Sci U S A , 100 :7877 , 2003
Abstract :
PubMedSearch : Garnier_2003_Proc.Natl.Acad.Sci.U.S.A_100_7877
PubMedID: 12788972
Gene_locus related to this paper: myctu-a85a , myctu-a85b , myctu-a85c , myctu-bpoC , myctu-cut3 , myctu-cutas1 , myctu-cutas2 , myctu-d5yk66 , myctu-ephB , myctu-ephc , myctu-ephd , myctu-ephE , myctu-hpx , myctu-linb , myctu-lipG , myctu-lipJ , myctu-LIPS , myctu-lipv , myctu-LPQC , myctu-LPQP , myctu-MBTB , myctu-metx , myctu-mpt51 , myctu-MT1628 , myctu-MT3441 , myctu-p71654 , myctu-p95011 , myctu-PKS6 , myctu-PKS13 , myctu-ppe42 , myctu-ppe63 , myctu-Rv1430 , myctu-RV0045C , myctu-Rv0077c , myctu-Rv0151c , myctu-Rv0152c , myctu-Rv0159c , myctu-Rv0160c , myctu-rv0183 , myctu-Rv0217c , myctu-Rv0220 , myctu-Rv0272c , myctu-RV0293C , myctu-RV0421C , myctu-RV0457C , myctu-RV0519C , myctu-RV0774C , myctu-RV0782 , myctu-RV0840C , myctu-Rv1069c , myctu-Rv1076 , myctu-RV1123C , myctu-Rv1184c , myctu-Rv1190 , myctu-Rv1191 , myctu-RV1192 , myctu-RV1215C , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-RV1639C , myctu-RV1683 , myctu-RV1758 , myctu-Rv1800 , myctu-Rv1833c , myctu-Rv2045c , myctu-RV2054 , myctu-Rv2284 , myctu-RV2296 , myctu-Rv2385 , myctu-Rv2485c , myctu-RV2627C , myctu-RV2672 , myctu-RV2695 , myctu-RV2765 , myctu-RV2800 , myctu-RV2854 , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-rv3177 , myctu-Rv3312c , myctu-RV3452 , myctu-RV3473C , myctu-Rv3487c , myctu-Rv3569c , myctu-RV3724 , myctu-Rv3802c , myctu-Rv3822 , myctu-y0571 , myctu-y963 , myctu-Y1834 , myctu-y1835 , myctu-y2079 , myctu-Y2307 , myctu-yc88 , myctu-ym23 , myctu-ym24 , myctu-YR15 , myctu-yt28

Title : Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains - Fleischmann_2002_J.Bacteriol_184_5479
Author(s) : Fleischmann RD , Alland D , Eisen JA , Carpenter L , White O , Peterson J , Deboy R , Dodson R , Gwinn M , Haft D , Hickey E , Kolonay JF , Nelson WC , Umayam LA , Ermolaeva M , Salzberg SL , Delcher A , Utterback T , Weidman J , Khouri H , Gill J , Mikula A , Bishai W , Jacobs Jr WR, Jr. , Venter JC , Fraser CM
Ref : Journal of Bacteriology , 184 :5479 , 2002
Abstract :
PubMedSearch : Fleischmann_2002_J.Bacteriol_184_5479
PubMedID: 12218036
Gene_locus related to this paper: myctu-a85a , myctu-a85b , myctu-a85c , myctu-bpoC , myctu-d5yk66 , myctu-ephA , myctu-ephB , myctu-ephc , myctu-ephd , myctu-ephE , myctu-ephF , myctu-hpx , myctu-linb , myctu-lipG , myctu-LPQP , myctu-MBTB , myctu-metx , myctu-mpt51 , myctu-MT3441 , myctu-p71654 , myctu-p95011 , myctu-PKS6 , myctu-PKS13 , myctu-ppe42 , myctu-ppe63 , myctu-Rv1430 , myctu-RV0045C , myctu-Rv0077c , myctu-Rv0151c , myctu-Rv0152c , myctu-Rv0159c , myctu-Rv0160c , myctu-rv0183 , myctu-Rv0217c , myctu-Rv0220 , myctu-Rv0272c , myctu-RV0293C , myctu-RV0421C , myctu-RV0457C , myctu-RV0519C , myctu-RV0774C , myctu-RV0782 , myctu-RV0840C , myctu-Rv1069c , myctu-Rv1076 , myctu-RV1123C , myctu-Rv1184c , myctu-Rv1190 , myctu-Rv1191 , myctu-RV1192 , myctu-RV1215C , myctu-Rv1399c , myctu-Rv1400c , myctu-RV1639C , myctu-RV1683 , myctu-RV1758 , myctu-Rv1800 , myctu-Rv1833c , myctu-Rv2045c , myctu-RV2054 , myctu-Rv2284 , myctu-RV2296 , myctu-Rv2385 , myctu-Rv2485c , myctu-RV2627C , myctu-RV2672 , myctu-RV2695 , myctu-RV2765 , myctu-RV2800 , myctu-RV2854 , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-rv3177 , myctu-Rv3312c , myctu-RV3452 , myctu-Rv3487c , myctu-Rv3569c , myctu-Rv3591c , myctu-RV3724 , myctu-Rv3802c , myctu-Rv3822 , myctu-y0571 , myctu-y963 , myctu-Y1834 , myctu-y1835 , myctu-y2079 , myctu-Y2307 , myctu-yc88 , myctu-ym23 , myctu-ym24 , myctu-YR15 , myctu-yt28

Title : Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence - Cole_1998_Nature_393_537
Author(s) : Cole ST , Brosch R , Parkhill J , Garnier T , Churcher C , Harris D , Gordon SV , Eiglmeier K , Gas S , Barry CE, 3rd , Tekaia F , Badcock K , Basham D , Brown D , Chillingworth T , Connor R , Davies R , Devlin K , Feltwell T , Gentles S , Hamlin N , Holroyd S , Hornsby T , Jagels K , Krogh A , McLean J , Moule S , Murphy L , Oliver K , Osborne J , Quail MA , Rajandream MA , Rogers J , Rutter S , Seeger K , Skelton J , Squares R , Squares S , Sulston JE , Taylor K , Whitehead S , Barrell BG
Ref : Nature , 393 :537 , 1998
Abstract :
PubMedSearch : Cole_1998_Nature_393_537
PubMedID: 9634230
Gene_locus related to this paper: myctu-a85a , myctu-a85b , myctu-a85c , myctu-bpoC , myctu-cut3 , myctu-cutas1 , myctu-cutas2 , myctu-d5yk66 , myctu-ephA , myctu-ephB , myctu-ephc , myctu-ephd , myctu-ephE , myctu-ephF , myctu-hpx , myctu-linb , myctu-lipG , myctu-lipJ , myctu-LIPS , myctu-lipv , myctu-LPQC , myctu-LPQP , myctu-MBTB , myctu-metx , myctu-mpt51 , myctu-MT1628 , myctu-MT3441 , myctu-p71654 , myctu-p95011 , myctu-PKS6 , myctu-PKS13 , myctu-ppe42 , myctu-ppe63 , myctu-Rv1430 , myctu-RV0045C , myctu-Rv0077c , myctu-Rv0151c , myctu-Rv0152c , myctu-Rv0159c , myctu-Rv0160c , myctu-rv0183 , myctu-Rv0217c , myctu-Rv0220 , myctu-Rv0272c , myctu-RV0293C , myctu-RV0421C , myctu-RV0457C , myctu-RV0519C , myctu-RV0774C , myctu-RV0782 , myctu-RV0840C , myctu-Rv1069c , myctu-Rv1076 , myctu-RV1123C , myctu-Rv1184c , myctu-Rv1190 , myctu-Rv1191 , myctu-RV1192 , myctu-RV1215C , myctu-Rv1399c , myctu-Rv1400c , myctu-Rv1426c , myctu-RV1639C , myctu-RV1683 , myctu-RV1758 , myctu-Rv1800 , myctu-Rv1833c , myctu-RV2054 , myctu-RV2296 , myctu-Rv2385 , myctu-Rv2485c , myctu-RV2627C , myctu-RV2672 , myctu-RV2695 , myctu-RV2765 , myctu-RV2800 , myctu-RV2854 , myctu-Rv2970c , myctu-Rv3084 , myctu-Rv3097c , myctu-rv3177 , myctu-Rv3312c , myctu-RV3452 , myctu-RV3473C , myctu-Rv3487c , myctu-Rv3569c , myctu-Rv3591c , myctu-RV3724 , myctu-Rv3802c , myctu-Rv3822 , myctu-y0571 , myctu-y963 , myctu-Y1834 , myctu-y1835 , myctu-y2079 , myctu-Y2307 , myctu-yc88 , myctu-ym23 , myctu-ym24 , myctu-YR15 , myctu-yt28