| Title : Therapeutic potential of targeting alpha\/beta-Hydrolase domain-containing 6 (ABHD6) - Deng_2020_Eur.J.Med.Chem_198_112353 |
| Author(s) : Deng H , Li W |
| Ref : Eur Journal of Medicinal Chemistry , 198 :112353 , 2020 |
| Abstract : alpha/beta-Hydrolase domain 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes monoacylglycerol (MAG) lipids, particularly the endogenous cannabinoid 2-arachidonoylglycerol (2-AG), in both central and peripheral tissues. ABHD6 and its substrates have been shown to be involved in the modulation of various (patho)physiological processes, including neurotransmission, inflammation, insulin secretion, adipose browning, food intake, autoimmune disorders, as well as neurological and metabolic diseases, making this enzyme a promising therapeutic target to treat several diseases. This review will focus on the molecular mechanism, biological functions and pathological roles of ABHD6, as well as recent efforts to develop ABHD6 inhibitors, providing a strong basis for the development of small molecules by targeting ABHD6 to treat diverse diseases. |
| ESTHER : Deng_2020_Eur.J.Med.Chem_198_112353 |
| PubMedSearch : Deng_2020_Eur.J.Med.Chem_198_112353 |
| PubMedID: 32371333 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
Deng H, Li W (2020)
Therapeutic potential of targeting alpha\/beta-Hydrolase domain-containing 6 (ABHD6)
Eur Journal of Medicinal Chemistry
198 :112353
Deng H, Li W (2020)
Eur Journal of Medicinal Chemistry
198 :112353