Deng_2020_Eur.J.Med.Chem_198_112353

Reference

Title : Therapeutic potential of targeting alpha\/beta-Hydrolase domain-containing 6 (ABHD6) - Deng_2020_Eur.J.Med.Chem_198_112353
Author(s) : Deng H , Li W
Ref : Eur Journal of Medicinal Chemistry , 198 :112353 , 2020
Abstract :

alpha/beta-Hydrolase domain 6 (ABHD6) is a transmembrane serine hydrolase that hydrolyzes monoacylglycerol (MAG) lipids, particularly the endogenous cannabinoid 2-arachidonoylglycerol (2-AG), in both central and peripheral tissues. ABHD6 and its substrates have been shown to be involved in the modulation of various (patho)physiological processes, including neurotransmission, inflammation, insulin secretion, adipose browning, food intake, autoimmune disorders, as well as neurological and metabolic diseases, making this enzyme a promising therapeutic target to treat several diseases. This review will focus on the molecular mechanism, biological functions and pathological roles of ABHD6, as well as recent efforts to develop ABHD6 inhibitors, providing a strong basis for the development of small molecules by targeting ABHD6 to treat diverse diseases.

PubMedSearch : Deng_2020_Eur.J.Med.Chem_198_112353
PubMedID: 32371333
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Related information

Gene_locus human-ABHD6    mouse-ABHD6
Family ABHD6-Lip

Citations formats

Deng H, Li W (2020)
Therapeutic potential of targeting alpha\/beta-Hydrolase domain-containing 6 (ABHD6)
Eur Journal of Medicinal Chemistry 198 :112353

Deng H, Li W (2020)
Eur Journal of Medicinal Chemistry 198 :112353