Mus musculus (Mouse) Monoacylglycerol lipase ABHD6
Monoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzympe hydrolyzing 26AG.(belong to Monoglyceridelipase_lysophospholip family) ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification<\/A> of Arpigny and Jaeger 1999. Alpha\/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al.<\/A>
Family : ABHD6-Lip
Block : X
Position in NCBI Life Tree : Mus musculus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N EMDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV RYAHHEDYQF CYSFRGRPGH KPSILMLHGF SAHKGMWLSV VKFLPKNLHL VCVDMPGHEG TTRSSLDDLS IVGQVKRIHQ FVECLKLNKK PFHLIGTSMG GHVAGVYAAY YPSDVCSLSL VCAAGLQYST DNPFVQRLKE LEESAAIQKI PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN SFYRKLFLEI VNEKSRYSLH ENMDKIKVPT QIIWGKQDQV LDVSGADILA KSISNSQVEV LENCGHSVVM ERPRKTAKLI VDFLASVHNT DNKKLN
| Title : ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility - Wei_2023_Prog.Neurobiol__102559 |
| Author(s) : Wei M , Yang L , Su F , Liu Y , Zhao X , Luo L , Sun X , Liu S , Dong Z , Zhang Y , Shi YS , Liang J , Zhang C |
| Ref : Prog Neurobiol , :102559 , 2023 |
| Abstract : |
| PubMedSearch : Wei_2023_Prog.Neurobiol__102559 |
| PubMedID: 38159878 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol\/PPAR signaling in obese mice - Poursharifi_2023_Mol.Metab__101822 |
| Author(s) : Poursharifi P , Schmitt C , Chenier I , Leung YH , Oppong AK , Bai Y , Klein LL , Al-Mass A , Lussier R , Abu-Farha M , Abubaker J , Al-Mulla F , Peyot ML , Madiraju SRM , Prentki M |
| Ref : Mol Metab , :101822 , 2023 |
| Abstract : |
| PubMedSearch : Poursharifi_2023_Mol.Metab__101822 |
| PubMedID: 37838014 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Wwl70-induced ABHD6 inhibition attenuates memory deficits and pathological phenotypes in APPswe\/PS1dE9 mice - Xue_2023_Pharmacol.Res__106864 |
| Author(s) : Xue Z , Ye L , Ge J , Lan Z , Zou X , Mao C , Bao X , Yu L , Xu Y , Zhu X |
| Ref : Pharmacol Res , :106864 , 2023 |
| Abstract : |
| PubMedSearch : Xue_2023_Pharmacol.Res__106864 |
| PubMedID: 37480972 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome - Westenbroek_2023_Neurobiol.Dis_180_106099 |
| Author(s) : Westenbroek R , Kaplan J , Viray K , Stella N |
| Ref : Neurobiol Dis , 180 :106099 , 2023 |
| Abstract : |
| PubMedSearch : Westenbroek_2023_Neurobiol.Dis_180_106099 |
| PubMedID: 36990366 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : The endocannabinoid 2-arachidonoylglycerol and dual ABHD6\/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity - Kokona_2021_Neuropharmacol_185_108450 |
| Author(s) : Kokona D , Spyridakos D , Tzatzarakis M , Papadogkonaki S , Filidou E , Arvanitidis KI , Kolios G , Lamani M , Makriyannis A , Malamas MS , Thermos K |
| Ref : Neuropharmacology , 185 :108450 , 2021 |
| Abstract : |
| PubMedSearch : Kokona_2021_Neuropharmacol_185_108450 |
| PubMedID: 33450278 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors - Malamas_2021_ChemMedChem__ |
| Author(s) : Malamas MS , Lamani M , Farah SI , Mohammad KA , Miyabe CY , Rajarshi G , Wu S , Zvonok N , Chandrashekhar H , Wood J , Makriyannis A |
| Ref : ChemMedChem , : , 2021 |
| Abstract : |
| PubMedSearch : Malamas_2021_ChemMedChem__ |
| PubMedID: 34486233 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement of CB(1) Receptors - Deng_2021_Cannabis.Cannabinoid.Res__ |
| Author(s) : Deng L , Viray K , Singh S , Cravatt B , Stella N |
| Ref : Cannabis Cannabinoid Res , : , 2021 |
| Abstract : |
| PubMedSearch : Deng_2021_Cannabis.Cannabinoid.Res__ |
| PubMedID: 34705543 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Termination of acute stress response by the endocannabinoid system is regulated through LSD1-mediated transcriptional repression of 2-AG hydrolases ABHD6 and MAGL - Longaretti_2020_J.Neurochem__e15000 |
| Author(s) : Longaretti A , Forastieri C , Gabaglio M , Rubino T , Battaglioli E , Rusconi F |
| Ref : Journal of Neurochemistry , :e15000 , 2020 |
| Abstract : |
| PubMedSearch : Longaretti_2020_J.Neurochem__e15000 |
| PubMedID: 32141088 |
| Gene_locus related to this paper: human-ABHD6 , human-MGLL , mouse-ABHD6 , mouse-MGLL |
| Title : Therapeutic potential of targeting alpha\/beta-Hydrolase domain-containing 6 (ABHD6) - Deng_2020_Eur.J.Med.Chem_198_112353 |
| Author(s) : Deng H , Li W |
| Ref : Eur Journal of Medicinal Chemistry , 198 :112353 , 2020 |
| Abstract : |
| PubMedSearch : Deng_2020_Eur.J.Med.Chem_198_112353 |
| PubMedID: 32371333 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Impact of tetrahydrocannabinol on the endocannabinoid 2-arachidonoylglycerol metabolism: ABHD6 and ABHD12 as novel players in human placenta - Maia_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids__158807 |
| Author(s) : Maia J , Fonseca BM , Cunha SC , Braga J , Goncalves D , Teixeira N , Correia-da-Silva G |
| Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , :158807 , 2020 |
| Abstract : |
| PubMedSearch : Maia_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids__158807 |
| PubMedID: 32829065 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : ABHD6: Its Place in Endocannabinoid Signaling and Beyond - Cao_2019_Trends.Pharmacol.Sci_40_267 |
| Author(s) : Cao JK , Kaplan J , Stella N |
| Ref : Trends in Pharmacological Sciences , 40 :267 , 2019 |
| Abstract : |
| PubMedSearch : Cao_2019_Trends.Pharmacol.Sci_40_267 |
| PubMedID: 30853109 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : alpha\/beta-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes - Zhao_2016_Cell.Rep_14_2872 |
| Author(s) : Zhao S , Mugabo Y , Ballentine G , Attane C , Iglesias J , Poursharifi P , Zhang D , Nguyen TA , Erb H , Prentki R , Peyot ML , Joly E , Tobin S , Fulton S , Brown JM , Madiraju SR , Prentki M |
| Ref : Cell Rep , 14 :2872 , 2016 |
| Abstract : |
| PubMedSearch : Zhao_2016_Cell.Rep_14_2872 |
| PubMedID: 26997277 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : alpha\/beta-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility - Fisette_2016_Cell.Rep_17_1217 |
| Author(s) : Fisette A , Tobin S , Decarie-Spain L , Bouyakdan K , Peyot ML , Madiraju SR , Prentki M , Fulton S , Alquier T |
| Ref : Cell Rep , 17 :1217 , 2016 |
| Abstract : |
| PubMedSearch : Fisette_2016_Cell.Rep_17_1217 |
| PubMedID: 27783937 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents - Griebel_2015_Sci.Rep_5_7642 |
| Author(s) : Griebel G , Pichat P , Beeske S , Leroy T , Redon N , Jacquet A , Francon D , Bert L , Even L , Lopez-Grancha M , Tolstykh T , Sun F , Yu Q , Brittain S , Arlt H , He T , Zhang B , Wiederschain D , Bertrand T , Houtmann J , Rak A , Vallee F , Michot N , Auge F , Menet V , Bergis OE , George P , Avenet P , Mikol V , Didier M , Escoubet J |
| Ref : Sci Rep , 5 :7642 , 2015 |
| Abstract : |
| PubMedSearch : Griebel_2015_Sci.Rep_5_7642 |
| PubMedID: 25560837 |
| Gene_locus related to this paper: mouse-ABHD6 |
| Title : alpha\/beta-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli - Zhao_2015_Mol.Metab_4_940 |
| Author(s) : Zhao S , Poursharifi P , Mugabo Y , Levens EJ , Vivot K , Attane C , Iglesias J , Peyot ML , Joly E , Madiraju SR , Prentki M |
| Ref : Mol Metab , 4 :940 , 2015 |
| Abstract : |
| PubMedSearch : Zhao_2015_Mol.Metab_4_940 |
| PubMedID: 26909310 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6\/2 Mice - Naydenov_2014_Neuron_83_361 |
| Author(s) : Naydenov AV , Horne EA , Cheah CS , Swinney K , Hsu KL , Cao JK , Marrs WR , Blankman JL , Tu S , Cherry AE , Fung S , Wen A , Li W , Saporito MS , Selley DE , Cravatt BF , Oakley JC , Stella N |
| Ref : Neuron , 83 :361 , 2014 |
| Abstract : |
| PubMedSearch : Naydenov_2014_Neuron_83_361 |
| PubMedID: 25033180 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |
| Title : Highly predictive ligand-based pharmacophore and homology models of ABHD6 - Bowman_2013_Chem.Biol.Drug.Des_81_382 |
| Author(s) : Bowman AL , Makriyannis A |
| Ref : Chemical Biology Drug Des , 81 :382 , 2013 |
| Abstract : |
| PubMedSearch : Bowman_2013_Chem.Biol.Drug.Des_81_382 |
| PubMedID: 23110439 |
| Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6 |