mouse-ABHD6

Mus musculus (Mouse) Monoacylglycerol lipase ABHD6

Comment

Monoacylglycerol lipase ABHD6 hydrolyses the endocannabinoid 2-arachidonoylglycerol (2-AG). 2-AG regulates neurotransmission and neuroinflammation by activating CB1 cannabinoid receptors on neurons and CB2 cannabinoid receptors on microglia. (A MGLL human-MGLL or MAGLL is the other enzympe hydrolyzing 26AG.(belong to Monoglyceridelipase_lysophospholip family) ABHD6 of animals is homologous to some bacterial enzymes. For bacterial enzymes, this family correspond to family V.1 of the classification<\/A> of Arpigny and Jaeger 1999. Alpha\/beta-Hydrolase domain 6 deletion induces adipose browning and prevents obesity and type 2 diabetes and is published by Zhao et al.<\/A>

Relationship

Family : ABHD6-Lip

Block : X

Position in NCBI Life Tree : Mus musculus

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No inhibitor

Database

Sequence

Peptide

MDLDVVNMFV IAGGTLAIPI LAFVASFLLW PSALIRIYYW YWRRTLGMQV RYAHHEDYQF CYSFRGRPGH KPSILMLHGF SAHKGMWLSV VKFLPKNLHL VCVDMPGHEG TTRSSLDDLS IVGQVKRIHQ FVECLKLNKK PFHLIGTSMG GHVAGVYAAY YPSDVCSLSL VCAAGLQYST DNPFVQRLKE LEESAAIQKI PLIPSTPEEM SEMLQLCSYV RFKVPQQILQ GLVDVRIPHN SFYRKLFLEI VNEKSRYSLH ENMDKIKVPT QIIWGKQDQV LDVSGADILA KSISNSQVEV LENCGHSVVM ERPRKTAKLI VDFLASVHNT DNKKLN

References (18)

Title : ABHD6 drives endocytosis of AMPA receptors to regulate synaptic plasticity and learning flexibility - Wei_2023_Prog.Neurobiol__102559
Author(s) : Wei M , Yang L , Su F , Liu Y , Zhao X , Luo L , Sun X , Liu S , Dong Z , Zhang Y , Shi YS , Liang J , Zhang C
Ref : Prog Neurobiol , :102559 , 2023
PubMedID: 38159878
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : ABHD6 suppression promotes anti-inflammatory polarization of adipose tissue macrophages via 2-monoacylglycerol\/PPAR signaling in obese mice - Poursharifi_2023_Mol.Metab__101822
Author(s) : Poursharifi P , Schmitt C , Chenier I , Leung YH , Oppong AK , Bai Y , Klein LL , Al-Mass A , Lussier R , Abu-Farha M , Abubaker J , Al-Mulla F , Peyot ML , Madiraju SRM , Prentki M
Ref : Mol Metab , :101822 , 2023
PubMedID: 37838014
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Wwl70-induced ABHD6 inhibition attenuates memory deficits and pathological phenotypes in APPswe\/PS1dE9 mice - Xue_2023_Pharmacol.Res__106864
Author(s) : Xue Z , Ye L , Ge J , Lan Z , Zou X , Mao C , Bao X , Yu L , Xu Y , Zhu X
Ref : Pharmacol Res , :106864 , 2023
PubMedID: 37480972
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : The serine hydrolase ABHD6 controls survival and thermally induced seizures in a mouse model of Dravet syndrome - Westenbroek_2023_Neurobiol.Dis_180_106099
Author(s) : Westenbroek R , Kaplan J , Viray K , Stella N
Ref : Neurobiol Dis , 180 :106099 , 2023
PubMedID: 36990366
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : ABHD6 Controls Amphetamine-Stimulated Hyperlocomotion: Involvement of CB(1) Receptors - Deng_2021_Cannabis.Cannabinoid.Res__
Author(s) : Deng L , Viray K , Singh S , Cravatt B , Stella N
Ref : Cannabis Cannabinoid Res , : , 2021
PubMedID: 34705543
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : The endocannabinoid 2-arachidonoylglycerol and dual ABHD6\/MAGL enzyme inhibitors display neuroprotective and anti-inflammatory actions in the in vivo retinal model of AMPA excitotoxicity - Kokona_2021_Neuropharmacol_185_108450
Author(s) : Kokona D , Spyridakos D , Tzatzarakis M , Papadogkonaki S , Filidou E , Arvanitidis KI , Kolios G , Lamani M , Makriyannis A , Malamas MS , Thermos K
Ref : Neuropharmacology , 185 :108450 , 2021
PubMedID: 33450278
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Design and Synthesis of Highly Potent and Specific ABHD6 Inhibitors - Malamas_2021_ChemMedChem__
Author(s) : Malamas MS , Lamani M , Farah SI , Mohammad KA , Miyabe CY , Rajarshi G , Wu S , Zvonok N , Chandrashekhar H , Wood J , Makriyannis A
Ref : ChemMedChem , : , 2021
PubMedID: 34486233
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Termination of acute stress response by the endocannabinoid system is regulated through LSD1-mediated transcriptional repression of 2-AG hydrolases ABHD6 and MAGL - Longaretti_2020_J.Neurochem__e15000
Author(s) : Longaretti A , Forastieri C , Gabaglio M , Rubino T , Battaglioli E , Rusconi F
Ref : Journal of Neurochemistry , :e15000 , 2020
PubMedID: 32141088
Gene_locus related to this paper: human-ABHD6 , human-MGLL , mouse-ABHD6 , mouse-MGLL

Title : Therapeutic potential of targeting alpha\/beta-Hydrolase domain-containing 6 (ABHD6) - Deng_2020_Eur.J.Med.Chem_198_112353
Author(s) : Deng H , Li W
Ref : Eur Journal of Medicinal Chemistry , 198 :112353 , 2020
PubMedID: 32371333
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Impact of tetrahydrocannabinol on the endocannabinoid 2-arachidonoylglycerol metabolism: ABHD6 and ABHD12 as novel players in human placenta - Maia_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids__158807
Author(s) : Maia J , Fonseca BM , Cunha SC , Braga J , Goncalves D , Teixeira N , Correia-da-Silva G
Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , :158807 , 2020
PubMedID: 32829065
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : ABHD6: Its Place in Endocannabinoid Signaling and Beyond - Cao_2019_Trends.Pharmacol.Sci_40_267
Author(s) : Cao JK , Kaplan J , Stella N
Ref : Trends in Pharmacological Sciences , 40 :267 , 2019
PubMedID: 30853109
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : alpha\/beta-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes - Zhao_2016_Cell.Rep_14_2872
Author(s) : Zhao S , Mugabo Y , Ballentine G , Attane C , Iglesias J , Poursharifi P , Zhang D , Nguyen TA , Erb H , Prentki R , Peyot ML , Joly E , Tobin S , Fulton S , Brown JM , Madiraju SR , Prentki M
Ref : Cell Rep , 14 :2872 , 2016
PubMedID: 26997277
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : alpha\/beta-Hydrolase Domain 6 in the Ventromedial Hypothalamus Controls Energy Metabolism Flexibility - Fisette_2016_Cell.Rep_17_1217
Author(s) : Fisette A , Tobin S , Decarie-Spain L , Bouyakdan K , Peyot ML , Madiraju SR , Prentki M , Fulton S , Alquier T
Ref : Cell Rep , 17 :1217 , 2016
PubMedID: 27783937
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents - Griebel_2015_Sci.Rep_5_7642
Author(s) : Griebel G , Pichat P , Beeske S , Leroy T , Redon N , Jacquet A , Francon D , Bert L , Even L , Lopez-Grancha M , Tolstykh T , Sun F , Yu Q , Brittain S , Arlt H , He T , Zhang B , Wiederschain D , Bertrand T , Houtmann J , Rak A , Vallee F , Michot N , Auge F , Menet V , Bergis OE , George P , Avenet P , Mikol V , Didier M , Escoubet J
Ref : Sci Rep , 5 :7642 , 2015
PubMedID: 25560837
Gene_locus related to this paper: mouse-ABHD6

Title : alpha\/beta-Hydrolase domain-6 and saturated long chain monoacylglycerol regulate insulin secretion promoted by both fuel and non-fuel stimuli - Zhao_2015_Mol.Metab_4_940
Author(s) : Zhao S , Poursharifi P , Mugabo Y , Levens EJ , Vivot K , Attane C , Iglesias J , Peyot ML , Joly E , Madiraju SR , Prentki M
Ref : Mol Metab , 4 :940 , 2015
PubMedID: 26909310
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : ABHD6 Blockade Exerts Antiepileptic Activity in PTZ-Induced Seizures and in Spontaneous Seizures in R6\/2 Mice - Naydenov_2014_Neuron_83_361
Author(s) : Naydenov AV , Horne EA , Cheah CS , Swinney K , Hsu KL , Cao JK , Marrs WR , Blankman JL , Tu S , Cherry AE , Fung S , Wen A , Li W , Saporito MS , Selley DE , Cravatt BF , Oakley JC , Stella N
Ref : Neuron , 83 :361 , 2014
PubMedID: 25033180
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Highly predictive ligand-based pharmacophore and homology models of ABHD6 - Bowman_2013_Chem.Biol.Drug.Des_81_382
Author(s) : Bowman AL , Makriyannis A
Ref : Chemical Biology Drug Des , 81 :382 , 2013
PubMedID: 23110439
Gene_locus related to this paper: human-ABHD6 , mouse-ABHD6

Title : Functional annotation of a full-length mouse cDNA collection - Kawai_2001_Nature_409_685
Author(s) : Kawai J , Shinagawa A , Shibata K , Yoshino M , Itoh M , Ishii Y , Arakawa T , Hara A , Fukunishi Y , Konno H , Adachi J , Fukuda S , Aizawa K , Izawa M , Nishi K , Kiyosawa H , Kondo S , Yamanaka I , Saito T , Okazaki Y , Gojobori T , Bono H , Kasukawa T , Saito R , Kadota K , Matsuda H , Ashburner M , Batalov S , Casavant T , Fleischmann W , Gaasterland T , Gissi C , King B , Kochiwa H , Kuehl P , Lewis S , Matsuo Y , Nikaido I , Pesole G , Quackenbush J , Schriml LM , Staubli F , Suzuki R , Tomita M , Wagner L , Washio T , Sakai K , Okido T , Furuno M , Aono H , Baldarelli R , Barsh G , Blake J , Boffelli D , Bojunga N , Carninci P , de Bonaldo MF , Brownstein MJ , Bult C , Fletcher C , Fujita M , Gariboldi M , Gustincich S , Hill D , Hofmann M , Hume DA , Kamiya M , Lee NH , Lyons P , Marchionni L , Mashima J , Mazzarelli J , Mombaerts P , Nordone P , Ring B , Ringwald M , Rodriguez I , Sakamoto N , Sasaki H , Sato K , Schonbach C , Seya T , Shibata Y , Storch KF , Suzuki H , Toyo-oka K , Wang KH , Weitz C , Whittaker C , Wilming L , Wynshaw-Boris A , Yoshida K , Hasegawa Y , Kawaji H , Kohtsuki S , Hayashizaki Y
Ref : Nature , 409 :685 , 2001
PubMedID: 11217851
Gene_locus related to this paper: mouse-1lipg , mouse-1plip , mouse-1plrp , mouse-ABH15 , mouse-abhd5 , mouse-ABHD6 , mouse-Abhd8 , mouse-aryla , mouse-bphl , mouse-cauxin , mouse-Ces1g , mouse-CPMac , mouse-dpp8 , mouse-EPHX1 , mouse-ES10 , mouse-hslip , mouse-hyes , mouse-ABHD2 , mouse-lcat , mouse-lipli , mouse-LIPN , mouse-lypla1 , mouse-lypla2 , mouse-OVCA2 , mouse-pafa , mouse-pcp , mouse-Ppgb , mouse-PPME1 , mouse-ppt , mouse-q3uuq7 , mouse-Q9DAI6 , mouse-Q80UX8 , mouse-RISC , mouse-SERHL , mouse-SPG21 , mouse-Tex30