| Title : Identification of key metabolic enzymes involved in the activation of obeldesivir and remdesivir to the active triphosphate metabolite - Xu_2026_Antimicrob.Agents.Chemother__e0005526 |
| Author(s) : Xu Y , Liclican A , Zhao X , Chen C , Ortega JT , Chuang HC , Soulette C , Chaudhuri S , Zhang J , Wang T , Babusis D , Marchand B , Sun KH , Ramirez R , Ma B , Nayak A , Wang L , Menon S , Belzile JP , Lai Y , Li L , Mackman RL , Bilello JP , Cihlar T , Feng JY , Lad L |
| Ref : Antimicrobial Agents & Chemotherapy , :e0005526 , 2026 |
| Abstract : |
| PubMedSearch : Xu_2026_Antimicrob.Agents.Chemother__e0005526 |
| PubMedID: 42363837 |
| Title : The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses - Martinez_2024_Sci.Transl.Med_16_eadj4504 |
| Author(s) : Martinez DR , Moreira FR , Catanzaro NJ , Diefenbacher MV , Zweigart MR , Gully KL , De la Cruz G , Brown AJ , Adams LE , Yount B , Baric TJ , Mallory ML , Conrad H , May SR , Dong S , Scobey DT , Nguyen C , Montgomery SA , Perry JK , Babusis D , Barrett KT , Nguyen AH , Nguyen AQ , Kalla R , Bannister R , Feng JY , Cihlar T , Baric RS , Mackman RL , Bilello JP , Schafer A , Sheahan TP |
| Ref : Sci Transl Med , 16 :eadj4504 , 2024 |
| Abstract : |
| PubMedSearch : Martinez_2024_Sci.Transl.Med_16_eadj4504 |
| PubMedID: 38776389 |
| Title : Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 That Exhibits Antiviral Efficacy in SARS-CoV-2-Infected African Green Monkeys - Mackman_2023_J.Med.Chem_66_11701 |
| Author(s) : Mackman RL , Kalla RV , Babusis D , Pitts J , Barrett KT , Chun K , Du Pont V , Rodriguez L , Moshiri J , Xu Y , Lee M , Lee G , Bleier B , Nguyen AQ , O'Keefe BM , Ambrosi A , Cook M , Yu J , Dempah KE , Bunyan E , Riola NC , Lu X , Liu R , Davie A , Hsiang TY , Dearing J , Vermillion M , Gale M, Jr. , Niedziela-Majka A , Feng JY , Hedskog C , Bilello JP , Subramanian R , Cihlar T |
| Ref : Journal of Medicinal Chemistry , 66 :11701 , 2023 |
| Abstract : |
| PubMedSearch : Mackman_2023_J.Med.Chem_66_11701 |
| PubMedID: 37596939 |
| Title : Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells - Li_2021_Antimicrob.Agents.Chemother__AAC0060221 |
| Author(s) : Li R , Liclican A , Xu Y , Pitts J , Niu C , Zhang J , Kim C , Zhao X , Soohoo D , Babusis D , Yue Q , Ma B , Murray BP , Subramanian R , Xie X , Zou J , Bilello JP , Li L , Schultz BE , Sakowicz R , Smith BJ , Shi PY , Murakami E , Feng JY |
| Ref : Antimicrobial Agents & Chemotherapy , :AAC0060221 , 2021 |
| Abstract : |
| PubMedSearch : Li_2021_Antimicrob.Agents.Chemother__AAC0060221 |
| PubMedID: 34125594 |
| Title : Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV - Sheahan_2020_Nat.Commun_11_222 |
| Author(s) : Sheahan TP , Sims AC , Leist SR , Schafer A , Won J , Brown AJ , Montgomery SA , Hogg A , Babusis D , Clarke MO , Spahn JE , Bauer L , Sellers S , Porter D , Feng JY , Cihlar T , Jordan R , Denison MR , Baric RS |
| Ref : Nat Commun , 11 :222 , 2020 |
| Abstract : |
| PubMedSearch : Sheahan_2020_Nat.Commun_11_222 |
| PubMedID: 31924756 |
| Title : Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys - Warren_2016_Nature_531_381 |
| Author(s) : Warren TK , Jordan R , Lo MK , Ray AS , Mackman RL , Soloveva V , Siegel D , Perron M , Bannister R , Hui HC , Larson N , Strickley R , Wells J , Stuthman KS , Van Tongeren SA , Garza NL , Donnelly G , Shurtleff AC , Retterer CJ , Gharaibeh D , Zamani R , Kenny T , Eaton BP , Grimes E , Welch LS , Gomba L , Wilhelmsen CL , Nichols DK , Nuss JE , Nagle ER , Kugelman JR , Palacios G , Doerffler E , Neville S , Carra E , Clarke MO , Zhang L , Lew W , Ross B , Wang Q , Chun K , Wolfe L , Babusis D , Park Y , Stray KM , Trancheva I , Feng JY , Barauskas O , Xu Y , Wong P , Braun MR , Flint M , McMullan LK , Chen SS , Fearns R , Swaminathan S , Mayers DL , Spiropoulou CF , Lee WA , Nichol ST , Cihlar T , Bavari S |
| Ref : Nature , 531 :381 , 2016 |
| Abstract : |
| PubMedSearch : Warren_2016_Nature_531_381 |
| PubMedID: 26934220 |
| Title : Implications of Efficient Hepatic Delivery by Tenofovir Alafenamide (GS-7340) for Hepatitis B Virus Therapy - Murakami_2015_Antimicrob.Agents.Chemother_59_3563 |
| Author(s) : Murakami E , Wang T , Park Y , Hao J , Lepist EI , Babusis D , Ray AS |
| Ref : Antimicrobial Agents & Chemotherapy , 59 :3563 , 2015 |
| Abstract : |
| PubMedSearch : Murakami_2015_Antimicrob.Agents.Chemother_59_3563 |
| PubMedID: 25870059 |
| Gene_locus related to this paper: human-CTSA |
| Title : Metabolism and antiretroviral activity of tenofovir alafenamide in CD4+ T-cells and macrophages from demographically diverse donors - Bam_2014_Antivir.Ther_19_669 |
| Author(s) : Bam RA , Birkus G , Babusis D , Cihlar T , Yant SR |
| Ref : Antivir Ther , 19 :669 , 2014 |
| Abstract : |
| PubMedSearch : Bam_2014_Antivir.Ther_19_669 |
| PubMedID: 24625459 |
| Gene_locus related to this paper: human-CTSA |